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简介：ChimonanthusplantswidelydistributedinsouthernareaofChina,whichhavealonghistoryofediblesandmedicine.PhytochemicalinvestigationshaveshownthatChimonanthusproduced143non-volatileconstituents,includingalkaloids,flavonoids,terpenoids,coumarinsandothers,whichexhibitsignificantanti-oxidant,anti-bacterial,anti-cancer,anti-inflammatory,antihyperglycemic,antihyperlipidemicandotherbiologicalactivities.Onthebasisofsystematicreviewingofliteratures,thisarticleoverviewsthenon-volatileconstituentsandpharmacologyofChimonanthusfromdomesticandforeignoverthelast30years(untilJune2018),andmayprovideausefulreferenceforthefurtherdevelopmentofChimonanthus.

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简介：ForaBanachSpaceXGarcia-FalsetintroducedthecoefficientR(X)andshowedthatifR(X)<2thenXhasafixedpoint.Inthispaper,wedefineameannon-expansivemappingTonXinthesensethat‖Tx-Ty‖≤a‖x-Y‖+b‖x-Ty‖foranyx,y∈X,wherea,5≥0,a+b≤1.WeshowthatifR(X)<2/(1+b)thenThasafixedpointinX.

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简介：为地k和二有限的组G和X，当G由组自守从权利对X起作用时，k空间(kXop)上有Hopf代数学结构*kG(看见定理2.1)，把由DX双、表示的非平衡的量称为(G)。在这份报纸，DX(G)的一些Hopf代数学性质被给，在DX(G)上的当k代数学被讨论，看的DX(G)的表示类型，代数学结构和模块范畴被学习。自从非平衡的量的Hopf代数学结构，两倍DX(G)概括平常的量为有限的组G的两倍D(G)，当一种特殊情况和DX(G)的通用R矩阵提供Yang-Baxter方程的更多的答案，关于在这份报纸的DX(G)的所有结果能也被用来描述D(G)。

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简介：ＴＨＥＣＯＮＴＩＮＵＯＵＳＣＡＳＴＩＮＧＰＲＯＢＬＥＭＷＩＴＨＮＯＮ－ＥＱＵＩＬＩＢＲＩＵＭＣＯＮＤＩＴＩＯＮＳ￥（吴少华，刘祖汉）ＷｕＳｈａｏｈｕａ（Ｄｅｐｔ．ｏｆＡｐｐｌ．Ｍａｔｈ．，ＷｕｈａｎＵｎｉｖ．ｏｆＨｙｄｒａｕｌｉｃａｎｄＥｌｅｃｔｒｉ...

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简介：Twenty-ninespeciesofbutterflieswerecollectedforobservationanddeterminationofthewingsurfacesusingaScanningElectronMicroscope(SEM).Butterflywingsurfacedisplaysstructuralanisotropisminmicro-,submicro-andnano-scales.Thescalesonbutterflywingsurfacearrangelikeoverlappingrooftiles.Therearesubmicrometricverticalgibbosities,horizontallinks,andnano-protuberancesonthescales.First-incline-then-dripmethodandfirst-drip-then-inclinemethodwereusedtomeasuretheSlidingAngle(SA)ofdropletonbutterflywingsurfacebyanopticalContactAngle(CA)measuringsystem.Relativelysmallerslidinganglesindicatethatthebutterflywingsurfacehasfineself-cleaningproperty.SignificantlydifferentSAsinvariousdirectionsindicatetheanisotropicself-cleaningpropertyofbutterflywingsurface.TheSAsonthebutterflywingsurfacewithoutscalesareremarkablylargerthanthosewithscales,whichprovesthecrucialroleofscalesindeterminingtheself-cleaningproperty.Butterflywingsurfaceisatemplatefordesignandfabricationofbiomimeticmaterialsandself-cleaningsubstrates.Thisworkmayofferinsightsintohowtodesigndirectionalself-cleaningcoatingsandanisotropicwettingsurface.

简介：转变生长因素--尾除了Smads利用大量的细胞内部的发信号小径调整细胞的功能的一个宽数组。这些不在经典中，non-Smad小径被占据ligand的受体直接激活到增强，稀释，或不那样调制下游地细胞的回答。这些non-Smad小径包括地图kinase小径，象Rho一样GTPase发信号小径，和phosphatidylinositol-3-kinase/AKT小径的各种各样的分支。这评论在non-Smad小径的分子、生物化学的机制的理解集中于最近的进展。另外，这些non-Smad小径的功能也被讨论。

简介：MeisymmetryandMeiconservedquantityforanon-holonomicsystemofnon-Chetaev'stypewithunilateralconstraintsintheNielsenstylearestudied.Thedifferentialequationsofmotionforthesystemaboveareestablished.ThedefinitionandthecriteriaofMeisymmetry,conditions,andexpressionsofMeiconservedquantitydeduceddirectlyfromtheMeisymmetryaregiven.Anexampleisgiventoillustratetheapplicationoftheresults.

简介：39Vibriocholerae的一个总数非，非，O139拉紧的O1从Dhaka城市的不同部分的表面水被孤立，孟加拉国。，显示出的这些种类ctx或zot基因缺乏的所有由PCRanalysis.Eighteen代表证明种类为enterotoxin生产使用被测试一个兔子ileal环模型，哪个生活8个种类和文化的房间6个种类过滤在ileal的生产液体累积循环。然而，任何一个都没他们生产热马厩毒素(圣)，由乳臭未干的老鼠试金检测了。在另一方面，中的15%个孤立由中国仓鼠卵巢(CHO)房间试金检测了的生产细胞毒素。乘集中的文化的五十紧张没对反霍乱毒素给任何沉淀素乐队的代表过滤，建议紧张生产了enterotoxin，它与已知的霍乱毒素(CT)antigenically不同。百分之八十个总数孤立被发现为易变的haemolysin由试管方法检测了的热积极，而，39%被Christie-Atkins-Munch-Petersen(营地)方法发现积极。然而，87%isolates是积极的因为紧张的haemagglutinin/protease和所有为mannose-sensitive-haemagglutinin试金是积极的。

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简介：在这份报纸，一个可伸缩的基于连接的流动控制计划为应用相关的network-on-chip(NoC)被建议。建议计划利用NoC，也就是交通的可预测性和丰富的电线资源的二个特殊特征，到完成重要表演改进。首先，爆炸注射数据被调整进经常的数据溪流，一个基于连接的方法被用来保证所有连接没在任何时间被过载。因而，在网络的包的数字被减少，导致减少的拥挤可能性并且改进了通讯性能。第二，中央控制器的简单体系结构被建议保证建议计划有小区域开销并且是可伸缩的。模拟结果证明与传统的switch-to-switch(圣)相比，流动控制计划和分配前基于流动控制计划，建议计划极大地增加产量并且与合理区域和精力开销砍倒平均潜伏。

简介：PTEN，phosphatidylinositol-3-kinase/AKT小径的一个否定管理者，是胰岛素发信号的一个重要调节的人。决定胰腺的Pten的新陈代谢的函数，我们产生了胰特定的Pten大美人(PPKO)鼠标。PPKO老鼠扩大了胰并且提高了acinar房间的增长。他们也展出了低血糖症，hypoinsulinemia，和改变的氨基的新陈代谢。尤其是，PPKO老鼠证明streptozotocin(STZ)的推迟的发作导致了糖尿病，到high-fat-diet(HFD)的偏导性的抵抗导致了糖尿病。在PPKO老鼠为抵抗调查机制到导致HFD的多糖症，我们在主要胰岛素应答的纸巾评估了AKTphosphorylation：肝，肌肉，和脂肪。我们发现在胰的Pten损失引起在肝发信号的AKT的举起。AKT和它的下游的底层GSK3尾的phosphorylation在PPKO老鼠的肝被增加，当没有Pten等位基因的可检测的切除，PTEN水平在PPKO老鼠的肝被减少时。戏剧性地揭示的Proteomics分析减少了在PPKO老鼠的肝78-kDa铺平调整葡萄糖的蛋白质(GRP78)，它可以也贡献用HFD喂的PPKO老鼠的更低的血葡萄糖水平。一起，我们的调查结果在新陈代谢的规定在肝揭示新奇回答到胰腺的缺点，把一种新尺寸加到理解糖尿病抵抗。

简介：AbstractObjective:There are few studies evaluating the impact of Aspirin-exacerbated respiratory disease (AERD) treatment on otologic symptoms. The aim of this study is to evaluate the effects of endoscopic sinus surgery (ESS) and aspirin desensitization (AD) on otologic symptoms in subjects with AERD.Methods:Retrospective chart review of adult patients diagnosed with AERD at our tertiary Care Academic Medical Center-Otorhinolaryngology Department. Charts of adult patients diagnosed with AERD who underwent ESS and ASA desensitization at our institution’s AERD Center from 2016 to 2019 were reviewed. Sino-Nasal Outcomes Test 22-item survey (SNOT-22) scores were evaluated for patients at various time points including: pre-surgery, post-surgery/pre-aspirin desensitization, and various times post-desensitization up to >12 months. Within the SNOT-22, otologic-specific subdomain scores were evaluated at similar time points. Patients on immunomodulatory medications other than corticosteroids were excluded from analysis.Results:SNOT-22 scores were analyzed for 121 patients. There was a significant improvement in overall SNOT scores from pre-surgery (44.62) to post surgery/pre-desensitization (23.34) (P < 0.0005). Similarly, SNOT-22 otologic-specific scores also improved after surgery prior to desensitization (3.19-2.04) (P = 0.005). Following AD, the improvement in the overall SNOT-22 continued to improve for up to 12 months (P < 0.005). While the otologic-specific SNOT-22 scores remained stable after surgery and ASA desensitization.Conclusion:ESS and AD reduce otologic-specific SNOT-22 scores and parallel trends in overall SNOT-22 scores. The effect of treatment is durable over the course of 12 months. Future work should aim to correlate otologic SNOT-22 scores with objective otologic data.