简介：Objectives:TocharacterizethedistributionpatternofbiovarsandserotypesofUreaplasmaurealyticuminnormalhealthywomen,sexuallytransmittedinfectionsclinicclientsandinsexworkers.Methods:Weculturedcervicalswabstakenfrom261physicalcheck-upclients,599STIclinicoutpatientsand98sexworkersusingcommercialselectivemedium.SomepositivecultureswerefurtherbiotypedandserotypedbyPCR.Results:(1)Biovar1ofU.urealyticum(95.0%),especiallysingleinfectionofserotype1,3,and6ofbiovar1,iscommonlyfoundinhealthywomen.(2)Uourealyticumismorecommonlyisolatedinsexworkers(90.8%)thaninphysicalcheck-upgroup(60.9%)andSTIoutpatientsgroup(61.3%)(P<0.001).(3)Biovar2infectionofU.urealyticumismoreprevalentinsexworkers(28.1%)andSTIoutpatientsgroup(26.6%)thanthatinphysicalcheck-upgroup(4.9%)(P<0.001).(4)MixedinfectioncausedbymorethanoneserotypeofU.urealyticumisincreasingfromphysicalcheck-upgroup(8.6%)toSTIoutpatients(12.4%)andtosexworkers(23.9%)(P<0.01).(5)Thereisnostatisticdifferenceinthedistributionofserotype1,3,and6ofbiovar1amongthesethreegroups(P=0.763).(6)ThePCRmethoddescribedhereisrelativelysimple,rapidandspecificforthebiotypingandserotypingofbiovar1ofU.urealyticum.Conclusion:weshouldpaymoreattentiontobiovar2andmixedinfectionthansingleinfectionofbiovar1ofU.urealyticuminclinicpractice.PCRisagoodmethodinbiotypingandserotyping.

简介：Inthispaper,weintroducetheclassofn-normedgeneralizeddifferencesequencesrelatedtolp-space.Somepropertiesofthissequencespacelikesolidness,symmetricity,convergence-freeetc.arestudied.Weobtainsomeinclusionrelationsinvolvingthissequencespace.

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简介：Inthispaperwestudytheone-dimensionalreflectedbackwardstochasticdifferentialequationswhicharedrivenbyBrownianmotionaswellasamutuallyindependentmartingaleappearinginadefaultablesetting.Usingapenalizationmethod,weprovetheexistenceanduniquenessofthesolutionstotheseequations.Asanapplication,weshowthatunderproperassumptionsthesolutionofthereflectedequationisthevalueoftherelatedmixedoptimalstopping-controlproblem.

简介：Objective:ToassesstheeffectofantiviraltherapyforhepatitisBvirus(HBV)-relatedhepatocellularcarcinoma(HCC)afterradicalhepatectomy.Methods:Atotalof478HBV-relatedHCCpatientstreatedbyradicalhepatectomywereretrospectivelycollected.Patientsinthetreatmentgroup(n=141)receivedpostoperativelamivudinetreatment(100mg/d),whereaspatientsinthecontrolgroup(n=337)didnot.Recurrence-freesurvival(RFS)rates,overallsurvival(OS)rates,treatmentsforrecurrentHCCandcauseofdeathwerecomparedbetweenthetwogroups.Propensityscorematching(PSM)analysiswasalsoconductedtoreduceconfoundingbiasbetweenthetwogroups.Results:The1-,3-,and5-yearRFSratesdidn’tsignificantlydifferbetweenthetwogroups(P=0.778);however,the1-,3-,and5-yearOSratesinthetreatmentgroupweresignificantlyhigherthanthoseinthecontrolgroup(P=0.002).Similarresultswereobservedinthematcheddata.SubgroupanalysisshowedthatantiviraltreatmentconferredasignificantsurvivalbenefitforBarcelonaClinicalLiverCancerstageA/Bpatients.FollowingHCCrecurrence,morepeopleinthetreatmentgroupwereabletochoosecurativetreatmentsthanthoseinthecontrolgroup(P=0.031).Forcauseofdeath,fewerpeopleinthetreatmentgroupdiedofliverfailurethanthoseinthecontrolgroup(P=0.041).Conclusion:PostoperativeantiviraltherapyincreaseschancesofreceivingcurativetreatmentsforrecurrentHCCandpreventsdeathbecauseofliverfailure,therebysignificantlyprolongingOS,especiallyinearly-orintermedian-stagetumors.

简介：AbstractBackground:Neglected tropical diseases (NTDs) have long been overlooked in the global health agenda. They are intimately related to poverty, cause important local burdens of disease, but individually do not represent global priorities. Yet, NTDs were estimated to affect close to 2 billion people at the turn of the millennium, with a collective burden equivalent to HIV/AIDS, tuberculosis, or malaria. A global response was therefore warranted.Main text:The World Health Organization (WHO) conceived an innovative strategy in the early 2000s to combat NTDs as a group of diseases, based on a combination of five public health interventions. Access to essential NTD medicines has hugely improved thanks to strong public-private partnership involving the pharmaceutical sector. The combination of a WHO NTD roadmap with clear targets to be achieved by 2020 and game-changing partner commitments endorsed in the London Declaration on Neglected Tropical Diseases, have led to unprecedented progress in the implementation of large-scale preventive treatment, case management and care of NTDs. The coming decade will see as challenges the mainstreaming of these NTD interventions into Universal Health Coverage and the coordination with other sectors to get to the roots of poverty and scale up transmission-breaking interventions. Chinese expertise with the elimination of multiple NTDs, together with poverty reduction and intersectoral action piloted by municipalities and local governments, can serve as a model for the latter. The international community will also need to keep a specific focus on NTDs in order to further steer this global response, manage the scaling up and sustainment of NTD interventions globally, and develop novel products and implementation strategies for NTDs that are still lagging behind.Conclusions:The year 2020 will be crucial for the future of the global response to NTDs. Progress against the 2020 roadmap targets will be assessed, a new 2021-2030 NTD roadmap will be launched, and the London Declaration commitments will need to be renewed. It is hoped that during the coming decade the global response will be able to further build on today's successes, align with the new global health and development frameworks, but also keep focused attention on NTDs and mobilize enough resources to see the effort effectively through to 2030.

简介：AbstractChronic hepatitis B virus (HBV) infection is a global public health problem, which can cause chronic hepatitis, liver cirrhosis, hepatocellular carcinoma (HCC), and other diseases. Antiviral therapy is the most critical measure to slow down the progression of chronic hepatitis B, prevent or delay cirrhosis, HCC, and other kinds of liver decompensation events. At present, the anti-hepatitis B virus drugs are mainly nucleoside (acid) analogues (NAs) and interferon. Each kind of antiviral drug has different effects on the clinical outcome of hepatitis B patients (such as HCC). In this paper, we discussed the biological characteristics, natural course and prognosis of HBV infection, the mechanism of HBV-related HCC, the effect of different antiviral drugs on patients’ outcome, predictive biomarkers and model for HBV clinical outcome, predictors of sustained response and recurrence after withdrawal of antiviral therapy, consideration of expanding therapeutic indications and antiviral therapy, hoping to give a hand to the clinical diagnosis and treatment of HBV.

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简介：AIM:Toinvestigatethediversecharacteristicsofdifferentpathologicalgradingsofgastricadenocarcinoma(GA)usingtumor-relatedgenes.METHODS:GAtissuesindifferentpathologicalgradingsandnormaltissuesweresubjectedtotissuearrays.Expressionsof15majortumor-relatedgenesweredetectedbyRNAinsituhybridizationalongwith3’terminaldigoxin-labeledanti-sensesinglestrandedoligonucleotideandlockednucleicacidmodifyingprobewithinthetissuearray.Thedataobtainedwereprocessedbysupportvectormachinesbyfourdifferentfeatureselectionmethodstodiscovertherespectivecriticalgene/genesubsetscontributingtotheGAactivitiesofdifferentpathologicalgradings.RESULTS:IncomparisonofpoorlydifferentiatedGAwithnormaltissues,tumor-relatedgeneTP53playsakeyrole,althoughothersixtumor-relatedgenescouldalsoachievetheAreaUnderCurve(AUC)ofthereceiveroperatingcharacteristicindependentlybymorethan80%.ComparingthewelldifferentiatedGAwithnormaltissues,wefoundthat11tumor-relatedgenescouldindependentlyobtaintheAUCbymorethan80%,butonlythegenesubsets,TP53,RBandPTEN,playakeyrole.Onlythegenesubsets,Bcl10,UVRAG,APC,Beclin1,NM23,PTENandRBcoulddistinguishbetweenthepoorlydifferentiatedandwelldifferentiatedGA.Noneofasinglegenecouldobtainavaliddistinction.CONCLUSION:Differentfromthetraditionalpointofview,thewelldifferentiatedcancertissueshavemorealterationsofimportanttumor-relatedgenesthanthepoorlydifferentiatedcancertissues.

简介：AIM:ToelucidatethemolecularmechanismsunderlyinghepatitisBvirus(HBV)occultinfectionofgenotypeC.METHODS:Atotalof10typesofhepatitisBsurfaceantigen(HBsAg)variantsfromaKoreanoccultcohortwereused.AfteracompleteHBVgenomeplasmidmutatedsuchthatitdoesnotexpressHBsAgandplasmidencoding,eachHBsAgvariantwastransientlyco-transfectedintoHuH-7cells.ThesecretioncapacityandintracellularexpressionoftheHBVvirionsandHBsAgsintheirrespectivevariantswereanalyzedusingreal-timequantitativepolymerasechainreactionassaysandcommercialHBsAgenzyme-linkedimmunosorbentassays,respectively.RESULTS:AllvariantsexhibitedlowerlevelsofHBsAgsecretionintothemediumcomparedwiththewildtype.Inparticular,ineightofthetenvariants,verylowlevelsofHBsAgsecretionthatweresimilartothenegativecontrolweredetected.Incontrast,mostvariants(9/10)exhibitednormalvirionsecretioncapacitiescomparablewith,orevenhigherthan,thewildtype.ThisprovidednewinsightintotheintrinsicnatureofoccultHBVinfection,whichleadstoHBsAgsero-negativenessbuthashorizontalinfectivity.Furthermore,mostvariantsgeneratedhigherreactiveoxidativespeciesproductionthanthewildtype.ThisfindingprovidespotentiallinksbetweenoccultHBVinfectionandliverdiseaseprogression.CONCLUSION:ThepresentlyobtaineddataindicatethatdeficiencyinthesecretioncapacityofHBsAgvariantsmayhaveapivotalfunctionintheoccultinfectionsofHBVgenotypeC.

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简介：ThesecondauthorstudiedthenonlinearstabilityofN-layerquasi-geostrophicflowsubjecttoperturbationsofparametersandinitialdata,andestablishedthestabilitycriteriafortheflowinquestion,whichinvolvefindingoutthelowesteigenvalueofanellipticboundaryvalueproblem.Inthispaperwhenthedomainisaperiodiczonalchannel,aformulaofthelowesteigenvalueisestablished,whichisusefulforfurtherstudiesandpracticalapplications.

简介：有在天气和气候的可预测性问题的三种普通类型，它各包含不同抑制非线性的优化问题：最大的可预言的时间，最大的预言错误的上面的界限，和最大的许可的起始的错误和参数错误的更低的界限的更低的界限。高度有效的算法被开发了解决第二个优化问题。并且这个优化问题能在现实主义的模型被使用让天气和气候学习最大的预言错误的上面的界限。尽管过滤策略被采用了解决另外的二个问题，直接答案甚至为一个很简单的模型是很费时间的，它因此在现实主义的模型限制这二个可预测性问题的适用性。在这份报纸，新策略被设计解决这些问题，包含存在的使用为第二个可预测性问题的高度有效的算法特别地。而且，在更旧的过滤策略之间的一系列比较和新方法被执行。这被表明新策略不仅输出象旧的一样的结果，而且也是更计算地有效的。这将建议学习在天气或气候的现实主义的预报模型与这二个非线性的优化问题联系的可预测性问题是可能的。关键词抑制了非线性的优化问题-可预测性-算法

简介：AIM:ToevaluatethehighsensitivityC-reactiveprotein(hsCRP),Fetuin-Aandmatrixγ-carboxyglutamateprotein(MGP)asthemainfactorsforvascularcalcificationandinflammationinserumofpatientswithadvancedage-relatedmaculardegeneration(ARMD)incomparisontohealthycontrols.METHODS:Thesubjectswere40patientswithchoroidalneovascularization(CNV)havingameanageof70.9±9.1yandamatchedgroupof49apparentlyhealthycontrolsubjects.TheARMDwasdiagnosedusingaslitlampwithsuperfieldlens,fundusphotographyandfluoresceinangiography.MeasurementofhsCRPwasdonebynephelometrymethod.LevelsofFetuin-AandMGPweremeasuredbyenzyme-linkedimmunosorbentassay(ELISA)technique.RESULTS:hsCRP[0.45(0.07-2.63)mg/Lvs0.25(0.03-1.2)mg/L,P=0.02)]andFetuin-Alevels(50.27±5.04vs44.99±10.28ng/mL,P=0.009)werehigherinthepatientsthaninthecontrolgroups.WecouldnotfindsignificantdifferenceinMGPlevelbetweentwogroups(P=0.08).TherewasnotasignificantcorrelationbetweenMGPwithFetuin-AandhsCRPamongthepatients(P=0.7,P=0.9respectively).AsignificantnegativecorrelationofhsCRPwithFetuin-Awasobservedinbothcaseandcontrolgroups(P=0.004,r=-0.33andP=0.001,r=-0.54,respectively).CONCLUSION:AlthoughourstudyshowsthatserumhsCRPandFetuin-AisincreasedinCNVpatientsaswellasnegativelycorrelatedwithbothstudygroups,theirdirectroleonpathogenesisofARMDrequiredfuturestudies.

简介：三个米饭变化，Zhonghan3，Shanyou63和Aizizhan，当在检测微分活跃甲基的材料骑车并且响应干旱应力转移相关基因表示，被使用。实验被在干旱的条件下面的微分显示器技术与10%PEG6000答案模仿了的基因薄片和mRNA执行。结果显示甲基周期能在Zhonghan3和Shanyou63的叶子被激活，但是在干旱应力下面在Aizizhan的叶子禁止了。而且，干旱应力能导致很多methyltransferase基因的表示，特别Rubisco蛋白质methylation的抄写联系了基因，它是有益的因为Rubisco蛋白质氧化和降级的预防，和干旱应力能禁止DNAmethyltransferase基因和histonemethyltransferase基因的抄写。这结果证实活跃甲基骑车并且转移相关基因涉及米饭干旱抵抗。

简介：Onthebisisofdeterminingthethereelementsofthemocline(depth[upperbounddepth],thicknessandintensity)andthemaximumverticaltemperaturegradientofthesurveyingstation,thepapercalculatesthemeantemperatureoftheNanshadeep-watersurveyingstationwithintheupper-bounddepthlayerofthermoclineandthemeantemperaturebelowthelowerbounddepthofthermoclinebetweenthe300mand800mlayers,respectively.AnalysisindicatesthatthehorizontaldistributionofmeanseawatertemperatureshowsadistincttrendofthelowtemperatureseawaterslowlymovingfromtbenortheasttothesoutheastofNansha,whichseemstohavebeendrivenbytheNortheastMonsoon.Thelargertheverticaltemperatureradientis,thegreaterisitscapabilityofpreventingtheheatoftheupperseawaterfromdiffusingintothedeeperlayersontheverticaldirection.

简介：为绿粪肥被栽培的钩子庄稼在改进土壤性质起一个重要作用。一个3年的地实验被进行调查钩子庄稼的效果(豌豆，PisumsativumL.)管理，即，在10月/11月(秋天)和三月(春天)的钩子庄稼的加入，并且没有钩子庄稼(控制)，在土壤上器官的碳(SOC)，微生物引起的生物资源碳(MBC)和碳(C)周期酶，包括的绗维素酶(Cel)，-glucosidase(Glu)和转化酶(Inv)的活动。另外，玷污全部的氮(TN)和pHKCl被调查。钩子庄稼每年在20082010期间从8月被栽培到10月。土壤样品从在钩子庄稼以后被种了的春天大麦(HordeumvulgareL.)的地被收集。为微生物引起的活动决心的土壤样品在2009，2010和2011在三月，5月，6月和8月被拿，当SOC和TN象pH一样满足KCl在三月和8月被决定。性质学习了的化学药品没显示出由试验性的因素影响了的重要变化。钩子庄稼的使用显著地与控制相比增加了MBC内容和C周期酶的活动。当钩子庄稼在春天被合并时，一个显著地更高的MBC内容与秋天加入相比在三月和5月被注意。而且，钩子庄稼的春天加入显著地增加了Glu活动(除了三月)，当时象基础呼吸通常是的土壤的率一样的Cel和Inv的活动未受影响等到钩子庄稼加入。在钩子的更大的微生物引起的生物资源和更高的酶活动与控制相比，当绿粪肥能被推荐为一种有希望的技术增加土壤的生物活动，对待庄稼的土壤显示钩子的申请收割。因为没有重要效果或没有一致结果与钩子庄稼加入的时间有关被获得，春天和秋天应用能被推荐为一个管理工具在随后的庄稼的生长期间改进土壤性质的地位。

简介：ObjectivesToinvestigatetherelatedpathogenicfactorsofhypertensionaffectingthemiddle-agedinsuburbanareasinMudanjiangCityandfurtherpopularizehealtheducationwithregardtohypertension.MethodsAsurveywasconductedon858middle-agedpeopleof35to59yearsoldfromsuchsuburbanareasasJinglongvillage,BadavillageandFengshouvillagebyadoptingthehypertensivedefinitionandclassifyingstandardofanWHO/ISHhypertensivetreatmentguidancein1999.ResultsPositivecorrelationwasshownbetweenoccurrenceofhypertensionandsuchelementsasdietinexcesssalt,drinking,obesity,smoking.ConclusionsItisofgreatclinicalsignificancetocombatandpreventthehypertensionbyregulatingone'sdietandlifestyle.

简介：LetT_1beasingularintegralwithnon-smoothkernelor±I,letT_2andT_4bethelinearoperatorsandletT_3=±I.DenotetheToeplitztypeoperatorbyT~b=T_1M~bI_αT_2+T_3I_αM~bT_4,whereM~bf=bf,andI_αisthefractionalintegraloperator.Inthispaper,weinvestigatetheboundednessoftheoperatorT~bontheweightedMorreyspacewhenbbelongstotheweightedBMOspace.