简介:Accordingtotheresultsofsiteseismichazardanalysisaccomplishedinthepastdecades,96site-relateddesignspectraareselectedassamplesinthisstudy.Theresultshowsthatthevalueofthecornerperiod(Tg)ofthedesignspectruminGBJ11-89(ChinaSeismicBuildingCode,issuedin1989)islowerthanthevalueobtainedbysiteseismichazardanalysis.ThesamesituationexistswhenwecomparethedesignspectraoftheCodestothespectraaccordingtotheearthquakerecords.Thevalueincurrentseismicdesigncode,GBJ50011-2001issuedin2001,isgreaterthanthatinGBJ11-89,butstilllessthanthevalueobtainedbysiteseismichazardanalysis.Ifweacceptthevaluegotbysiteseismichazardanalysis,wehaveasuspicionthat2/3ofbuildingsbuiltaccordingtoGBJ11-89willnotbesafewhenanearthquakewith2%probabilityofexceedancein50yearsoccurs.
简介:AbstractInnate lymphoid cells (ILCs) are a group of lymphocytes without diversified antigen receptors encoded by gene rearrangement on T and B cells. ILCs, which are tissue-resident innate immune cells, expressed particularly in the mucosa or the barrier surface, contribute to the formation of lymphoid organs, the maintenance of tissue homeostasis, and the regulation of antimicrobial defenses. It has been recently reported that ILCs were enriched at the maternal-fetal interface. During a successful pregnancy, the maternal immune system must tolerate a fetus as an allograft. With the new defined of ILCs, a number of studies have shown that three types of ILCs are involved in embryonic development and pregnancy maintenance as well as the occurrence and development of pregnancy-related complications. This article reviews the types and roles of ILCs in normal pregnancy and pregnancy-related diseases.
简介:Thesediment-hosteddisseminatedgolddepositsintheOinlingregionareofsedimentation-slight-metamorphicoriginsuperimposedbyhydrothermalreworkingatmoderate-lowtemperaturesandarewellcomparablewiththetypicalCarlingolddepositsintheUnitedStates.Inviewoftheconfusingconceptconcerningthe“sediment-hosted”and“Carlin-type”golddeposits,theauthorsproposethattheterm“sediment-hostedgolddeposit”shouldbeusedinabroadsensewhichencompassesatleastthefoursubtypes,i.e.,theCarlintype,themetamorphicfineclastictype,thehydrothermalsedimentarytypeandtheveintype.Inoterwords,the“Carlin-type”shouldnotbeusedasasynonymfor“sediment-hosted”butisrecommendedasasubtypeunderthegeneralcategoryof“sediment-hostedgolddeposits”
简介:Aim:Methodforthedeterninationoferythromycinethylsuccinale(EES)byionsuppressionchromatography(ISC)wasdevelopedandtheinfluencfactorsonISCwereinvestigated.Methods:AZorbaxSB-C18columnwasusedwith0.02mol.L^-1potassiumdihydrogenphosphate-acetonitrile(45:55)asmobilephase,ThepHandproportionofthemobilephaseshowedthegreatestinfluencesonretentionandselectivity.Therefore,thepHofmobilewasadjustedto6.8,thebhestacetonitrileproportionwas55%.Thecolumntemperaturewasmaintainedat(300±0.5)℃.AcetonitrilewasusedassolventforthesamplepreparationbecauseEESismorestableinit.Theflowratewas1.2mL.min^-1andUVdetectionwasperformedat210nm.Results:Underthesechromatographicconditions,themaincomponent(erythromycinAethylsuccinate)anditsrelatedsubstanceswereseparated.Thecalibrationcurveshowedgoodlinearityovertherangeof0.1-1.0mg.mL^-1,anditscorrelationcoefficientwas0.9998.Conclusion:Themethodisverysuitablefortheanalysisoferythromycinethylsuccinate.
简介:1.Majorforeign-relatedadministrativeorganizations:TheForeign-relatedOfficeoftheHebeiProvincialPeople’sGovernmentTheMerchantsCompanyofHebeiProvinceAddress:WeimingStreetNo.10,Shijiazhuang,Hebei,ChinaTel:704260370426057092417Fax:(86)311-70426027042603
简介:Objective:Toclonemultidrugresistance(MDR)relatedgenesinlungadenocarcinomacelllines.Methods:ThedifferentiallyexpressedcDNAfragmentsbetweenA549andA549DDPcellswereanalyzedbymRNAdifferentialdisplayPCR(DDRT-PCR).ThefragmentsthusobtainedwerefurtheranalyzedbyDNAsequencingandNorthernblotting.Results:ThreedifferentiallyexpressedcDNAfragmentswereobtainedandconfirmedbyNorthernblot.Sequenceanalysisrevealedthattwoofthemwerenovelandonewas100%identicalwithICEgene.Conclusion:AnalyzingdifferentiallyexpressedfragmentbetweenA549andA549DDPcellsmaybehelpfulforfindingnewMDRrelatedgenes.ThedrugresistanceofA549DDPcellsmayberelatedtotheinhibitionordown-regulationofICEgene.
简介:在这份报纸,我们首先随思考调查零和的二播放器的随机的微分比赛,在理论的帮助下反映了向后的随机的微分方程(RBSDE)。我们将建立动态编程原则为上面并且有以一个直接方法的思考的这种随机的微分比赛的更低的价值功能。然后上面并且更低的值函数被证明是的唯一的粘性答案联系上面并且有障碍的更低的Hamilton-Jacobi-Bellman-Isaacs方程分别地。方法与随思考为控制问题使用的那些显著地不同,与自己兴趣开发的新技术。进一步,我们也为在ElKaroui,Kapoudjian,Pardoux,Peng和Quenez(1997)的纸是比那锋利的RBSDE证明新估计,因为它允许我们由向前开车的起始的价值的距离的p-th力量估计二不同RBSDE的答案的Lp距离,它结果很有用方程。我们也证明penalization方法构造的接近的以撒方程的唯一的粘性答案与障碍收敛到以撒方程的粘性答案。
简介:AbstractThere is currently no universally accepted unified diagnostic standard for infertility treatment and maternity protection related to polycystic ovary syndrome (PCOS) worldwide, and the treatment options vary greatly. To improve the understanding of PCOS-related infertility among Chinese obstetricians and gynecologists at all levels for better patient diagnosis and management, we have referred to the international expert recommendations and literature and taken into account the Chinese clinical practice to develop the "Consensus on infertility management and fertility preservation related to PCOS."
简介:<正>China’sforeign--relatedtaxsystemwasestablishedanddevelopedintheprocessofdeepeningthereformandopeningtotheoutsideworldbegin-ningin1979.SincetheThirdPlenarySessionoftheEleventhCentralCommitteeoftheChineseCommunistParty,tomeetthedemandsofthenewsituationofopeningtotheoutsideworld,severallawswerepromul-
简介:Coastallowlandshavelargeareasofhazardimpactandrelativelylowcapacityofpreventiontothewaterrelatedhazards,whichhavebeenindicatedbythewide-spreadfloodhazards,highpercentagesoflandwithhighfloodvulnerability.Increasingpopulationpressureandtheshiftofresourcesexploitationfromlandtoseawillforcemoreandmorecoastallowlandstobedevelopedinthefuture,furtherenhancingthedangerofwater-relatedhazards.Inthispaper,thecoastallowlandsinthenorthernJiangsuprovince,China,wereselectedasacasestudy.TheInterpretationStructuralModel(ISM)wasemployedtoanalyzethedirectandindirectimpactsamongtheelementswithinthesystem,andthereby,toidentifythecausalelements,middlelinkages,theirexpressions,andrelations.
简介:UndergroundprospectingwithintheLubin-Sieroszowiceminingareawhichtookplaceduringlast5years,ledtoadiscoveryofanewtypeofAu,PtandPdmineralisationlocated0-0.5mbelowthecopper-silverorebodyinthesouth-westernpartofthePolishPermianBasin.Thegold-bearingzoneliesmainlyintheWeissliegendessandstone(IowerPermian),butlocallytransgressesthestratigraphicsequenceintotheoverlyingkupferschieferandWerralimestone(Zechstein).
简介:AbstractMink has been identified as an animal with susceptibility to SARS-CoV-2 and also as the only animal with evidence to transmit the virus back to humans. Thus, the surveillance of viruses among high-density farmed minks has a significant meaning for the control of zoonotic emerging diseases in humans. Within anal swabs of minks that died of unknown causes in a mink farm, mink calicivirus (MCV) and mammalian orthoreovirus (MRV) were detected and simultaneously observed within MDCK cell culture from the sample of the same lethal mink. The parallel isolation was successfully performed by utilizing cell lines from different host sources with distinct viral sensitivities, i.e. Mv.1.Lu and Vero-E6 and the two viruses were independently separated. The prevalence of the virus among the minks and its genomic characteristics were investigated through deep sequencing technology. Phylogenetic analysis of the viral genome showed a close relationship of the newly isolated MCV-GCCDC8-2020 with MCV strains belonging to the genus Vesivirus, but with unique mutations derived from the major structural protein (VP1). The reovirus MRV-GCCDC9-2020 isolated from the same mink belongs to serotype 3 mammalian orthoreovirus and genome analysis showed a potential reassortment derived from reoviruses in different species. This study provides a beneficial reference on viral co-infection within disease investigation in farmed minks and raises the concern for the virus surveillance among the high-density fed animal farms.
简介:AbstractBackground:Antiretroviral therapy (ART) has reduced mortality among people living with HIV (PLWH) in China, but co-infections of hepatitis B virus (HBV) and hepatitis C virus (HCV) may individually or jointly reduce the effect of ART. This study aimed to evaluate the impacts of HBV/HCV coinfections on treatment drop-out and mortality among PLWH on ART.Methods:A retrospective cohort study analysis of 58,239 people living with HIV (PLWH) who initiated antiretroviral therapy (ART) during 2010-2018 was conducted in Guangxi Province, China. Data were from the observational database of the National Free Antiretroviral Treatment Program. Cox proportional hazard models were fitted to evaluate the effects of baseline infection of HBV or HCV or both on death and treatment attrition among PLWH.Results:Our study showed high prevalence of HBV (11.5%), HCV (6.6%) and HBV-HCV (1.5%) co-infections. The overall mortality rate and treatment attrition rate was 2.95 [95% confidence interval (CI): 2.88-3.02] and 5.92 (95% CI: 5.82-6.01) per 100 person-years, respectively. Compared with HIV-only patients, HBV-co-infected patients had 42% higher mortality [adjusted hazard ratio (aHR)=1.42; 95% CI 1.32-1.54], HCV-co-infected patients had 65% higher mortality (aHR=1.65; 95% CI: 1.47-1.86), and patients with both HCV and HBV co-infections had 123% higher mortality (aHR=2.23; 95% CI:1.87-2.66).Conclusions:HBV and HCV coinfection may have an additive effect on increasing the risk of all-cause death among PLWH who are on ART. It is suggested that there is need for primary prevention and access to effective hepatitis treatment for PLWH.
简介:Objectives:ToprovidereferencesforHIV/AIDS-re-latedhealtheducationstrategiesthroughsurveyonHIV/AIDS-relatedknowledge,attitudeanddetermi-nantsofHIV/AIDSawareness.Methods:Thestudysubjectswereselectedbyran-dominterceptioninadowntownstreetofGuangzhoucityonWorldAIDSDay-December1,2002.Theuni-formquestionnaireswerefinishedbymeansofself-administration.Results:Twohundredquestionnairesweredistrib-utedand147qualifiedquestionnaireswerecollected.Theresultsshowed,theawarenessrateofHIV/AIDS-relatedknowledgewas63.3%,andawarenessrateoftransmissionrouteswas76.2%,whilstnon-transmis-sionroutewas60.5%;theawarenessrateoftrans-missionwas59.2%;theawarenessrateofpreventionwas47.0%;thepositiveattitudetopeoplelivingwithHIV/AIDSwas65.6%.MultiplevariableLogisticre-gressionanalysisshowedthedeterminantsofHIV/AIDS-relatedknowledgewereeducationlevel,age,maritalstatusandgender,ofwhichpeoplewithhighlevelofeducation,youngageandthegroupofmaleandmarriedhadbetterawarenessofHIV/AIDS.Conclusion:CurrentHIV/AIDS-relatedknowledgeofurbanresidentsisrelativlylow,especiallyforthenon-transmissionroute,hencefurtherHIV/AIDS-re-latededucationshouldbestrengthened,especiallyfo-cusingonnon-transmissionroutetoeliminatedis-criminationoverpeoplelivingwithHIV/AIDS.Further,educationeffortsalsoshouldbeputonfe-malepopulation,unmarriedpopulationandpoorlyedu-catedpopulation.