简介：Alaboratory-basedaerobicincubationwasconductedtoinvestigatenitrogen(N)isotopicfractionationrelatedtonitrificationinfiveagriculturalsoilsafterapplicationofammoniumsulfate((NH4)2SO4).Thesoilsampleswerecollectedfromasubtropicalbarrenlandsoilderivedfromgranite(RGB),threesubtropicaluplandsoilsderivedfromgranite(RQU),Quaternaryredearth(RGU),QuaternaryXiashuloess(YQU)andatemperateuplandsoilgeneratedfromalluvialdeposit(FAU).Thefivesoilsvariedinnitrificationpotential,beingintheorderofFAU>YQU>RGU>RQU>RGB.SignificantNisotopicfractionationaccompaniednitrificationofNH+4.δ15NvaluesofNH+4increasedwithenhancednitrificationovertimeinthefouruplandsoilswithNH+4addition,whilethoseofNO-3decreasedconsistentlytotheminimumandthereafterincreased.δ15NvaluesofNH+4showedasignificantlynegativelinearrelationshipwithNH+4-Nconcentration,butapositivelinearrelationshipwithNO-3-Nconcentration.TheapparentisotopicfractionationfactorcalculatedbasedonthelossofNH+4was1.036forRQU,1.022forRGU,1.016forYQU,and1.020forFAU,respectively.Zero-andfirst-orderreactionkineticsseemedtohavetheirlimitationsindescribingthenitrificationprocessaffectedbyNH+4inputinthestudiedsoils.Incontrast,Nkineticisotopefractionationwascloselyrelatedtothenitrifyingactivity,andmightserveasanalternativetoolforestimatingthenitrificationcapacityofagriculturalsoils.

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简介：我们将与光滑的模量有关仔细介绍Banach空间X的新几何经常的A(X)，它是X(),并且与经常的A在关系调查它由Baronti等的2(X)，vonNeumann约旦经常的CNJ(X)和詹姆士常数J(X)。象一些另外的几何常数一样的这些常数上的最近的结果的一个序列将被加强并且改善。

简介：ThispapercalculatesthestaticCoulombstresschangesgeneratedbyfourearthquakesintheYutianareaduring2008~2014separately,thendiscussesthetriggeringinfluence,theiraccumulatedCoulombstresschangesandtheirinfluenceonnearbyfaults.TheresultsindicatethattheMS5.5earthquakein2011andtheM_S7.3earthquakein2014arebothintheregionswheretheCoulombstresschangeispositive,thestresschangesare0.004MPaand0.021MPa,respectively,meaningtheyaretriggeredbypriorearthquakes.TheMS6.2earthquakein2012occurredintheplacewhereCoulombstresschangewasnegative,soitispostponedbythepriorearthquakes.TheimageofCoulombstresschangesoftheMS7.3earthquakein2014isinaccordwithaftershocks(ML≥3.0)distribution,butsomeregionsonthefaultwheretheCoulombstresschangeispositivehavefewaftershocks,andstrongaftershocksmayoccuratthesedistrictsinfuture.Inaddition,thispapercalculatestheCoulombstresschangeonnearbyfaults,andfindsthattheCoulombstresschangesofdifferentelementsintheGGCfaultareverydifferent,andmustreceivestrongtriggered-influence,thoughtheresultmaybeinfluencedbytheinputfinitefaultmodel,sothereisstillalargeearthquake-risk.TheGGN,PLC,PLWandLBWfaultswerealsotriggeredbythefourearthquakesoccurringbetween2008~2014.TheirmaximumCoulombstresschangesallexceed0.002MPa,sotheyalsohaveastrongearthquakehazard.

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简介：在apoptotic小径以内的缺点在前列腺癌症(PCa)被含有tumorigenesis，变形前进和治疗抵抗。癌症的一个特点是出轨的能力由禁止apoptotic信号，减少apoptotic蛋白质的表达式或放大幸存的apoptosis通过antiapoptotic的增加的生产发信号分子。这评论描述在热吃惊蛋白质(HSP)和人的雄激素之间的协会受体(AR)，HSP的角色和在PCa开发的另外的导致压力的蛋白质和在指向这些保护的蛋白质对待PCa的新兴的策略。

简介：Inthispaper,weintroducetheclassofn-normedgeneralizeddifferencesequencesrelatedtolp-space.Somepropertiesofthissequencespacelikesolidness,symmetricity,convergence-freeetc.arestudied.Weobtainsomeinclusionrelationsinvolvingthissequencespace.

简介：Sitobionavenae(F.)是能在Poaceae在各种各样的植物上幸存的世界范围的一个重要谷物害虫，但是不同主人植物上的分叉的选择应该支持专业化遗传型或主人赛跑的进化。为了评估他们的资源，使用策略，S的克隆。avenae从燕麦和大麦被收集。为这些克隆的主人转移实验在实验室被进行比较他们的健康特点。我们的结果证明大麦克隆有显著地更低的肥沃并且趋于有从大麦转移到燕麦的更长发展的时间。然而，在他们被转移到大麦以后，燕麦克隆更快发展了。从燕麦和大麦的克隆以肥沃和美女的发展时间分叉到某个程度。大麦克隆的分离和S的燕麦克隆。avenae在主要部件分析也是明显的。大麦克隆趋于比燕麦克隆为健康特点有更高宽广感觉的可遗传性，显示在他们之间的区别的基因基础。大麦克隆从专门化的二项措施与燕麦克隆相比显示出专门化的显著地更高的程度(即，Xsp和Ysp)。因此，大麦克隆被专业化到某个程度，但是燕麦克隆看起来被概括。S的健康。avenae克隆趋于与专门化的更高的程度增加。向在S的生态的专门化的进化。avenae克隆，以及内在的基因基础，被讨论。

简介：ThisstudyexaminedtheeffectofsalinityontheexpressionofNa+/K+-ATPase(NKA)α-subunitandvacuolar-typeH+-ATPase(V-ATPase)β-subunitgeneinthegillofLitopenaeusvannamei.Semi-quantitativereversetranscription-polymerasechainreaction(RT-PCR)assayshowedthattheexpressionofNKAα-subunitandV-ATPaseβ-subunitgenewassignificantlyinfluencedbysalinity.ItwasfoundthattheNKAactivitysignificantlyvariedwithsalinityintimeanddosedependentmanner;whereastheV-ATPaseactivitydidnot.TheabundanceofNKAα-subunitgenetranscriptincreasedrapidlywhenthesalinitydecreasedfrom26bto21,andslowlywhenthesalinitydecreasedfrom26to31withinthefirst24h.Whenthesalinitydecreasedfrom26to21,thetranscriptionofNKAα-subunitgeneingillepitheliumwashigherat12hthanthatat0h,whichwasconsistentwiththeresultofimmunoblottingassayofNKAα-subunit.Inaddition,salinityhadasignificanttime-anddose-dependenteffectontheconcentrationofbiogenicaminesinbothhemolymphandgill.Ascomparedtootherparameters,theconcentrationofdopamine(DA)and5-hydroxytryptamine(5-HT)variedindifferentpatternswhenthesalinitydecreasedfrom26to21orincreasedfrom26to31,suggestingthatDAand5-HTplayeddifferentregulatoryrolesinosmoticadaptionandmodulationofshrimpwhensalinityvaries.

简介：TheAppellateBodyreportinJanuary2012hadsupportedthedecisionofPanelinthe"China-measuresrelatedtotheexportationofvariousrawmaterials"case(WT/DS394,395,398)andaffirmedthatChina’srestrictions(suchastariffsandquotameasures)ontheexportationofrawmaterialsviolatedrulesputforthbytheWTO,whichwererequiredtobemodified.InthiscaseChina’srighttoinvokeArticle20ofGATT1994("generalexception")tojustifyitsexemptionfromtheguidelinesinArticle11.3oftheWTOAccessionProtocolwasdeniedbythePanelandtheAppellateBody.ThiswasduetothefactthatthephrasinginArticle11.3ofProtocolfailedtomention"GATT."ThiswastheconsequenceofthetwointerpretationapproachestheDisputeSettlementBody(DSB)adopted-anarrowtextualinterpretationandasubjectivepresumptionof"legislativesilence."TheinappropriateuseofthetwomethodsofinterpretationleadtoanimbalancebetweentherightandobligationofChinaundertheadditionalobligationsthatwereimposeduponChinabytheWTO,whichcreateanegativeimpactonChina’srareearthcaseandtheprotectionofdomesticnaturalresources.

简介：这份现在的报纸处理对线性轴、扭力的颤动的数学描述。正常、正切的压力张肌部件在推进器和中间的柄由轴扭力的变丑和颤动生产了，在导致推进器的静电干扰的影响下面，可变水动力学刺激也被学习。与微分方程答案的经常的系数有关的转移矩阵方法被使用。当邻近的柄片断有一样的材料性质和直径时，作为与转移的一个著名方法相比，矩阵与州的向量联系了的后者的优点是减少乘的矩阵的数字的可能性。结果证明没有弄弯的风险并且证实轴线的强度取决于是应力张肌的最重要的部件的静态的正切的压力的价值。

简介：AIM:Tocomparetheeffectivenessandsafetybetweenbevacizumabandranibizumabinthetreatmentofagerelatedmaculardegeneration(AMD)throughasystematicreviewandmeta-analysis.METHODS:Weperformedacomprehensivesearchofrandomizedcontrolledtrials(RCTs),non-RCTs,casecontrolandcohortstudiesthatcomparedbevacizumabandranibizumabusingPubMedandtheCochraneLibrary.Aftertherelateddatawereextractedbytwoinvestigatorsindependently,pooledweightedmeandifferences(WMDs)andriskratios(RRs)with95%confidenceintervals(CIs)wereestimatedusingarandom-effectsorafixed-effectsmodel.RESULTS:AtotaloffourRCTsinvolving1927patientsandelevenretrospectivecaseseriesinvolving2296patientswereincluded.Fortheprimaryoutcomes,nosignificantdifferenceswerefoundbetweenranibizumabgroupandbevacizumabgroupinvisualacuity(WMD:-0.04;95%CI:-0.08to0.00;P=0.06),bestcorrectedvisualacuity(WMD:-0.05;95%CI:-0.10to0.00;P=0.05),retinathickness(WMD:-4.69;95%CI:-13.15to3.76;P=0.86)andfovealthickness(WMD:10.91;95%CI:-14.73to36.56;P=0.40).Thepooledanalysesintheevaluationofsafetyshowedthatcomparedtobevacizumab,ranibizumabwasassociatedwithdecreasedrisksofocularinflammation(RR:0.45;95%CI:0.23to0.89;P=0.02)andvenousthromboticevents(RR:0.27;95%CI:0.08to0.89;P=0.03).However,therewerenosignificantdifferencesobservedindeaths(P=0.69)andarterialthromboembolicevents(P=0.71)betweenthetwogroups.CONCLUSION:Withequalclinicalefficacy,ranibizumabwasfoundtobeassociatedwithlessadverseeventscomparedtobevacizumab,indicatingthatranibizumabmightbeasafermanagement.

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简介：在CD4系抄写因素ThPok和CD8系抄写因素之间的相互影响，老牛相关的抄写因素3(Runx3)，在T房间，开发广泛地被记录了。然而，很少在不变的自然漂亮T(iNKT)房间开发对这些抄写因素的角色被知道。限制CD1d的iNKT房间承诺CD4+CD8−和CD4−CD8−sublineages，它对抗原刺激作出回应与快速并且T助手(Th)的有势力版本1并且Th2cytokines。然而，以前的报告在ThPok缺乏的老鼠表明了CD8+NKT房间的一张新人口。在当前的学习，我们寻求了决定Runx3是否当ThPok不在时涉及CD8的重新表示和iNKT房间的功能。我们使用了缺乏Runx3，ThPok或两个的老鼠并且证实Runx3为在ThPok猛烈老鼠的CD8+iNKT房间的外观部分负责。另外，Runx3参予了有免疫力的反应在α的一个模型由iNKT房间调停了；-galactosylceramide-induced尖锐肝炎。这些结果显示Runx3为在ThPok缺乏的iNKT房间观察的phenotypic和功能的变化是关键的。

简介：为了观察中国草药的忿恨的效果，在endothelin(et)和calcitonin的集中上与三步的tuina操作结合了基因相关的肽(CGRP)和在有脊椎的动脉的病人的眩晕颈的spondylosis(休假)。

简介：AIM:Tocomparetheefficacyandsafetyofcombinationofranibizumabwithphotodynamictherapy(PDT)vsranibizumabmonotherapyinthetreatmentofage-relatedmaculardegeneration(AMD).METHODS:TheCochraneCentralRegisterofControlledTrials(CENTRAL)intheCochraneLibrary,Pubmed,andEmbaseweresearched.Therewerenolanguageordatarestrictionsinthesearchfortrials.Onlyrandomizedcontrolledtrials(RCTs)wereincluded.MethodologicalqualityoftheliteratureswasevaluatedaccordingtotheJadadScore.RevMan5.2.6softwarewasusedtodothemeta-analysis.RESULTS:Sevenstudieswereincludedinoursystematicreview,amongwhichfourofthemwereincludedinquantitativeanalysis.Theresultshowsthattheranibizumabmonotherapygrouphadabettermeanbestcorrectedvisualacuity(BCVA)changevsbaselineatmonth12comparedwiththatofthecombinationtreatmentgroup,andthestatisticaldifferencewassignificant(WMD,-2.61;95%CI,-5.08to-0.13;P=0.04).However,aftertheremovalofonestudy,thedifferencebetweenthetwogroupsshowednosignificantdifference(WMD,-2.29;95%CI,-4.81to0.23;P=0.07).Meanwhile,nosignificantcentralretinalthickness(CRT)reductionwasfoundinthecombinationtreatmentgroupandtheranibizumabmonotherapygroupat12monthsfollow-up.Nevertheless,thecombinationgrouptendedtohaveagreaterreductioninCRT(WMD,-4.13μm;95%CI,-25.88to17.63,P=0.71).Theproportionofpatientsgainingmorethan3linesatmonth12intheranibizumabgroupwashigherthaninthecombinationgroupandtherewasasignificantdifference(RR,0.72;95%CI,0.54to0.95;P=0.02).Whereastherewasnosignificantdifferencefortheproportionofpatientsgainingmorethan0lineatmonth12betweenthetwogroups(RR,0.93;95%CI,0.76to1.15;P=0.52).Thegeneraltendencyshowsareductioninranibizumabretreatmentnumberinthecombinationtreatmentgroupcomparedwiththeranibizumabmonotherapygroup.Asmajoradverseevents,thedifferencesinthenumberofeyepain,endophthalmitis,hypertensionandarterialt