简介：Inflammationplaysanimportantroleinatherosclerosis.Inflammasomesplayacrucialroleininnateimmunity,whichmediatesthebody’sresponsetovariouspathogens.Ofthedifferenttypesofinflammasomes,NLRP3hasbeenimplicatedinatherosclerosisthroughtheproductionofproinflammatorycytokines,IL-1βandIL-18.ThisreviewdescribestheroleoftheNLRP3inflammasomeinatherosclerosisanddiscussespotentialtherapeutictargetsintheinflammasomepathway.

简介：Atherosclerosisisadiseaseofthearterialwallthatunderliesrmnyoftheverycommoncausesofcardiovascularmortality,includingmyocardialinfarction(MI),peripheralvasculardiseaseandcerebrovasculardisease.Earlypathologicaldescriptionsviewedatherosclerosisasanend-stagedegenerativediseactthatinevitablyresultedinageneralizednarrowingofthearteriallumen.

简介：Thehumangutmicrobiotaiscomposedofmorethan100trillionmicrobes.MostcommunitiesaredominatedbyspeciesbelongingtothephylaBacteroidetes,Firmicutes,Actinobacteria,Proteobacteria,andVerrucomicrobia.Microflora-derivedshort-chainfattyacidsplayapivotalroleintheframeworkofinsulinresistance,obesity,andmetabolicsyndrome.Theyareanimportantenergysourceandareinvolvedinseveralpathways,withproatherogenicandantiatherogeniceffects.Theincreasedgutmicrobiotalipopolysaccharidelevels(definedas“metabolicendotoxemia”)induceastateoflow-gradeinflammationandareinvolvedinatheroscleroticdiseasethroughToll-likereceptor4.Anotherimportantinflammatorytriggeringutmicrobiota–mediatedatheroscleroticpromotionistrimethylamineN-oxide.Ontheotherhand,protocatechuicacidwasfoundtopromotecholesteroleffluxfrommacrophages,showinganantiatherogeniceffect.Furtherstudiestoclarifyspecificgutcompositioninvolvedincardiometabolicsyndromeandatherogenesisareneededforgreateruseoftargetedapproaches.

简介：这研究试图决定血浆睾丸激素是否在经历了选任的冠的angiography的一组803个人与冠的动脉粥样硬化的严厉被联系。睾丸激素层次在根据睾丸激素水平tertiles被分成三个组的803个男病人被测量。所有病人经历了选任的冠的angiography，并且冠的动脉疾病(CAD)的严厉被Gensini分数决定。而且，病人们根据Gensini分数被分类进二个组(20≤；26和20>；26)用是的中部的价值，截止指。血浆睾丸激素层次被一个ELISA工具包测量。睾丸激素的水平否定地与Gensini分数被联系(r=−；0.188；P=0.000)。多重线性回归分析表明那睾丸激素是为Gensini分数的一个独立风险因素(β；=−；0.110；P=0.002)在为使covariates惊讶调整以后。在multivariate逻辑回归模型，CAD的严厉被显示在第三tertile显著地更低(最高)与第一tertile相比的睾丸激素(最低)睾丸激素(机会比率(或)=0.465；95%；信心间隔(CI)：0.327-0.662；P=0.000)。在这研究，有更低的睾丸激素层次的病人在经历了选任的冠的angiography的一组803个人有更高的Gensini分数。另外的研究被需要澄清诱发性和可能的位于\O下面机制的方向。

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简介：AbstractAn increasing body of evidence supports the hypothesis that atherosclerosis is caused by multiple factors and mechanisms. A better understanding of the contribution of hypertriglyceridemia or oleic acid to the pathogenesis of atherosclerosis would significantly increase our ability to successfully treat these diseases. We propose that oleic acid promotes atherosclerosis via multiple pathophysiological mechanisms. Here we suggest that (1) atherosclerosis may develop through multiple pathophysiological mechanisms and that this may be a common feature of human diseases; (2) diseases may be the consequence of natural selection or the interaction of internal and external factors; (3) diseases should be recognized with "biological diversity," and that this concept should be introduced into medical education, clinical treatment, drug research and development, and medical research. The work reported here will benefit a new generation of medical trainees and promote the development of the relevant medical fields.

简介：AbstractIntracranial atherosclerosis (ICAS)-related large vascular occlusion (LVO) was an intractable subtype of acute ischemic stroke (AIS), which always needed rescue angioplasty and stenting and complicated the procedure of endovascular recanalization. Diagnosing ICAS-LVO accurately and early was helpful for both clinical treatment and trials. Digital subtraction angiography (DSA) was unable to provide an early and rapid diagnosis of ICAS-LVO based on current studies. A variety of pre-DSA methods had been used to distinguish ICAS-LVO with other subtypes of ischemic stroke, such as medical histories, clinical presentations, computed tomography or angiography (CT/CTA), and magnetic resonance imaging (MRI/MRA). This article briefly reviewed the status quo of the diagnosis and treatment of ICAS-LVO and summarized early diagnostic methods of ICAS-LVO from different aspects.

简介：BackgroundStudieshaveshownthattheapo(a)gene(LPA)rs3798220polymorphismisassociatedwiththelevelsoflipidsandthecurativeeffectofstatintherapyforcarotidatherosclerosis(CAS).Whethercarriersofanapo(a)variantbenefitmorefromstatinremainsunclear.MethodsOnehundredandthreepatientswithCASwererecruitedfromApril2012toApril2013intheShundeFirstPeoplesHospitalAffiliatedtoSouthernMedicalUniversityinFoshan.Allpatientswereadministeredatorvastatin20mg/dandwerefollowed-upfor2years.withthelevelsofplasmaLp(a),totalcholesterol(TC),triglyceride(TG),highdensitylipoprotein(HDL),lowdensitylipoprotein(LDL).LPArs3798220genotypesofallpatientswereanalyzed.ResultsStatintreatmentsignificantlyreducedthelevelsofIMT,TC,TG,LDLandincreasedthelevelofHDL,butstatintreatmentdidnotreducethelevelofLp(a).AccordingtothecurativeeffectofstatintherapyinpatientswithCAS,rs3798220polymorphismhadacertaininfluenceonLDLandTClevels,butnotontheimprovementoftheIMT,TG,HDLandLp(a).ConclusionRs3798220polymorphismhasacertainimpactonthecurativeeffectsofstatin,onLDLandTClevels.

简介：AbstractBackground:Regulated upon activation, normal T-cell expressed, and secreted (RANTES) is a chemokine actively involved in the initiation and progression of atherosclerosis (AS), which is the major cause of ischemic cerebrovascular disease (ICVD). This study aimed to determine the associations between circulating RANTES level and overall AS conditions of cardiac and cerebral vessel beds in patients with ICVD.Methods:Patients with ICVD admitted to the department of neurology of Xuanwu Hospital from April 1, 2019 to June 30, 2019 were prospectively enrolled in the study. Plasma RANTES level was measured by enzyme-linked immunosorbent assay to represent the circulating RANTES level. The integrated AS burden of the cervicocephalic and coronary arteries was examined using computed tomography angiography and reflected by "cardio-cerebral AS burden (CCAB)" as a continuous variable. Then, the relationship of plasma RANTES level and CCAB in patients with ICVD was analyzed by correlation analyses and general linear models.Results:A total of 40 patients with ICVD were included in the study. There was a significant positive correlation between CCAB and plasma RANTES level in ICVD (r = 0.786, P < 0.001), independent of age, sex, acute or chronic phase of ICVD, and mono or dual antiplatelet therapy (adjusted B for ln RANTES, 12.063; 95% confidence interval, 7.572-16.533). The association of plasma RANTES level with AS conditions (burden, severity, and extent) in single cardiac or cerebral vessel bed was similar to that with CCAB, but the correlation coefficient for CCAB was higher (increment ranged from 0.126 to 0.397).Conclusions:Plasma RANTES level was an independent indicator for the integrated AS burden of the cervicocephalic and coronary arteries in ICVD. Comprehensive evaluation of AS conditions using the novel continuous index CCAB might be important in revealing the systematic relationship between circulating RANTES and AS in patients with ICVD.

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