Effects of apolipoprotein A polymorphism on plasma levels of lipids, progression of carotid atherosclerosis and response to statin therapy-中国期刊网

摘要 BackgroundStudieshaveshownthattheapo(a)gene(LPA)rs3798220polymorphismisassociatedwiththelevelsoflipidsandthecurativeeffectofstatintherapyforcarotidatherosclerosis(CAS).Whethercarriersofanapo(a)variantbenefitmorefromstatinremainsunclear.MethodsOnehundredandthreepatientswithCASwererecruitedfromApril2012toApril2013intheShundeFirstPeoplesHospitalAffiliatedtoSouthernMedicalUniversityinFoshan.Allpatientswereadministeredatorvastatin20mg/dandwerefollowed-upfor2years.withthelevelsofplasmaLp(a),totalcholesterol(TC),triglyceride(TG),highdensitylipoprotein(HDL),lowdensitylipoprotein(LDL).LPArs3798220genotypesofallpatientswereanalyzed.ResultsStatintreatmentsignificantlyreducedthelevelsofIMT,TC,TG,LDLandincreasedthelevelofHDL,butstatintreatmentdidnotreducethelevelofLp(a).AccordingtothecurativeeffectofstatintherapyinpatientswithCAS,rs3798220polymorphismhadacertaininfluenceonLDLandTClevels,butnotontheimprovementoftheIMT,TG,HDLandLp(a).ConclusionRs3798220polymorphismhasacertainimpactonthecurativeeffectsofstatin,onLDLandTClevels.

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Effects of apolipoprotein A polymorphism on plasma levels of lipids, progression of carotid atherosclerosis and response to statin therapy

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Effects of apolipoprotein A polymorphism on plasma levels of lipids, progression of carotid atherosclerosis and response to statin therapy

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