简介：AbstractBackground:Regulated upon activation, normal T-cell expressed, and secreted (RANTES) is a chemokine actively involved in the initiation and progression of atherosclerosis (AS), which is the major cause of ischemic cerebrovascular disease (ICVD). This study aimed to determine the associations between circulating RANTES level and overall AS conditions of cardiac and cerebral vessel beds in patients with ICVD.Methods:Patients with ICVD admitted to the department of neurology of Xuanwu Hospital from April 1, 2019 to June 30, 2019 were prospectively enrolled in the study. Plasma RANTES level was measured by enzyme-linked immunosorbent assay to represent the circulating RANTES level. The integrated AS burden of the cervicocephalic and coronary arteries was examined using computed tomography angiography and reflected by "cardio-cerebral AS burden (CCAB)" as a continuous variable. Then, the relationship of plasma RANTES level and CCAB in patients with ICVD was analyzed by correlation analyses and general linear models.Results:A total of 40 patients with ICVD were included in the study. There was a significant positive correlation between CCAB and plasma RANTES level in ICVD (r = 0.786, P < 0.001), independent of age, sex, acute or chronic phase of ICVD, and mono or dual antiplatelet therapy (adjusted B for ln RANTES, 12.063; 95% confidence interval, 7.572-16.533). The association of plasma RANTES level with AS conditions (burden, severity, and extent) in single cardiac or cerebral vessel bed was similar to that with CCAB, but the correlation coefficient for CCAB was higher (increment ranged from 0.126 to 0.397).Conclusions:Plasma RANTES level was an independent indicator for the integrated AS burden of the cervicocephalic and coronary arteries in ICVD. Comprehensive evaluation of AS conditions using the novel continuous index CCAB might be important in revealing the systematic relationship between circulating RANTES and AS in patients with ICVD.

简介：目的：研究针刺对中风偏瘫痉挛状态的影响。方法：采用修改的Ashworth痉挛评定级、Brunnstrom分级、Barthel日常生活能力（ActivitiesofDailyLiving，ADL）指数分别评定痉挛程度、运动功能水平、日常生活能力，观察头针、体针联合应用对中风后偏瘫患者痉挛状态的影响。结果：头针、体针联合应用对痉挛状态的改善，对运动功能水平及日常生活能力的影响均优于单纯体针治疗（P〈0．01）。结论：头针、体针联合应用在改善痉挛状态方面有独特的优势，可提高患者的运动功能水平及日常生活能力。

简介：Conventionalrecommendationsfordiagnostictestingfortheevaluationofstableischemicheartdiseaseinwomenhavelargelyparalleledthoseinmen.Althoughtheyaredesignedprimarilyfortheidentificationofobstructivecoronaryarterydisease(CAD),traditionalapproachescanleadtoovertestinginwomenwithoutdifferentiatingwhoistrulyatrisk.Severaluniquefactorsrelatedtothepresentation,diagnosis,andunderlyingpathophysiologyofstableischemicheartdiseaseinwomennecessitateamorespecificapproachtotheassessmentoftheirrisk,completewithseparateguidelineswhenappropriate.Thisoverviewhighlightshowadvancednoninvasiveimagingtools,includingcardiaccomputedtomographyangiography,positronemissiontomography,andcardiacmagneticresonanceimaging,areenablingverysensitiveassessmentsofanatomicatheroscleroticplaqueburden,macrovessel-andmicrovessel-relatedischemia,andmyocardialfibrosis,respectively.Movingforward,effectivediagnostictestingwillneedtoidentifywomenathighriskofadversecardiovascularevents(notanatomicallyobstructiveCADperse)withoutovertestingthoseatlowrisk.JudiciousapplicationofnovelimagingapproacheswillbecriticaltobroadeningthedefinitionsofCADandischemiatobetterreflectthewholespectrumofpathologicalphenotypesinwomen,includingnonobstructiveCADandcoronarymicrovasculardysfunction,andaidinthedevelopmentofneededevidence-basedstrategiesfortheirmanagement.

简介：【摘要】 目的 观察颈部血管超声应用于缺血性脑血管病患者的临床价值。方法 选取我院2013年6月—2015年6月诊治的124例缺血性脑血管病发病初期患者为研究组，同期选取124例健康受检者为对照组。两组受检者均在常规检查的基础上进行颈部血管超声检查，观察两组受检者的动脉粥样硬化斑块、颈动脉狭窄、颈动脉中膜厚与脑血流动力学指标等情况。结果 研究组颈动脉与脑血流动力学指标情况均高于对照组，差异有统计学意义(P

简介：AbstractBackground:The impacts of previous cardio-cerebrovascular disease (pre-CCVD) on the outcomes of hematopoietic cell transplantation (HCT) are not well described. Patients with pre-CCVD may often be poor candidates for HCT. This study aimed to investigate the impact of pre-CCVD on transplant outcomes.Methods:A retrospective study was conducted between patients with and without pre-CCVD who consecutively received allogeneic or autologous HCT between November 2013 and January 2020 with a matching of age and disease status. The cardiovascular complications and HCT outcomes of the two groups were evaluated and compared. The primary endpoints were post-transplant cardio-cerebrovascular disease (post-CCVD) and non-relapse mortality (NRM). We used a multivariable Cox proportional hazard model and the Fine-Gray competing risk regressions for analyses to estimate the hazard ratios (HRs).Results:The outcomes of 23 HCT recipients with pre-CCVD were compared with those of 107 patients in the control group. No significant differences were noted in terms of engraftment, overall survival (OS) (67.00% vs. 67.90%, P = 0.983), or relapse (29.78% vs. 28.26%, P = 0.561) between the pre-CCVD group and the control group. The cumulative incidences of 2-year NRM were similar between patients with pre-CCVD and the controls (14.68% vs. 17.08%, P = 0.670). However, pre-CCVD was associated with an increased incidence of post-CCVD (HR: 12.50, 95% confidence interval [CI]: 3.88-40.30, P < 0.001), which was an independent risk factor for increased NRM (HR: 10.29, 95% CI: 3.84-27.62, P < 0.001) and inferior OS (HR: 10.29, 95% CI: 3.84-27.62, P < 0.001).Conclusions:These findings suggest that the existence of pre-CCVD before transplantation might not result in increased mortality directly but superpose the toxicity of the transplantation procedure, leading to a risk of post-CCVD. Post-CCVD was a powerful predictor for high NRM and inferior OS. Further risk stratification of pre-CCVD is needed to reduce NRM in various transplantation settings.

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简介：A57-year-oldmanreportedexperiencingdyspneaafterwalking100feetthathasbeenprogressingdespitemedicaltherapy.Hehastwo-pilloworthopneaandoccasionalnighttimedyspneabutnoangina.Hehadananteriormyocardialinfarction5yearspreviouslybutdidnotseekmedicalcareuntil2daysaftertheevent.Viabilitystudiesdemonstratedonlylimitedanteriorwallviability.–Electrocardiogram:sinusrhythmwithleftbundlebranchblock.–Medications:furosemide,120mgtwicedaily;metolazone,5mgeveryotherday;carvedilol,25mgtwicedaily;lisinopril,40mgdaily;spironolactone,25mgdaily.

简介：瞄准：观察效果是在老鼠肝细胞的cyclinD1表示上的化学家preconditioning在期间早是化学家灌注。方法：54只SD老鼠随机被划分成是preconditioning组(IP)，ischemia/reperfusion组(红外)和假冒的操作组织的化学家(那么)。IP和红外组进一步被划分成四亚群(n=6)。假冒的操作组(那么)担任了控制组(n=6)。部分肝ischemia/reperfusion的一个模型被使用，在哪个老鼠在灌注以前为60min受到肝局部缺血。在IP组的动物经历了在ischemia/reperfusion挑战以前每次为5min是化学家preconditioning两次。在灌注的0，1，2，和4h以后，在每个组的浆液和肝织物被收集检测浆液中高音，肝组织病理学说和cyclinD1mRNA和蛋白质的表示的水平。流动血细胞计数被用来作为房间新生的数量指示物检测房间周期。结果：与红外组相比，IP组在1h显示出显著地更低的中高音水平到4h亚群(P<0.05)。增长索引(PI)由S阶段和G2/M-phase比率显示了[(S+G2/M)/(G0/G1+S+G2/M)]显著地在0和1h在IP组被增加(26.44+/-7.60%对18.56+/-6.40%，41.87+/-7.27%对20.25+/-6.70%，P<0.05)。同时，cyclinD1蛋白质表示能在IP组被检测。但是在红外组，，cyclinD1蛋白质表示发生了在灌注以后的2h。在IP显著地增加的cyclinD1mRNA的表示在0和1h组织(0.568+/-0.112对0.274+/-0.069，0.762+/-0.164对0.348+/-0.093，P<0.05)。结论：局部缺血preconditioning能保护肝细胞免于ischemia/reperfusion损害，它可能早与房间增长和cyclinD1的表示有关在期间是化学家灌注。

简介：AIMTo探索在网膜的血容器的氧浸透怎么在ischemic和non-ischemic分支被改变网膜的静脉吸藏(BRVO).METHODSFiftyBRVO眼睛被划分成ischemic(n=26)和non-ischemic(n=24)组，基于宫底荧光黄angiography。健康个人(n=52和n=48，分别地)也为二个组作为控制被招募。堵塞容器和中央容器的吝啬的氧浸透被oximetry在BRVO和控制groups.RESULTSIn测量ischemicBRVO组，堵塞小动脉氧浸透(SaO2-一，106.0%±；14.3%)，而不是堵塞小静脉氧浸透(SaO2-V,60.8%±；9.4%)，看了增加什么时候与那些相比在一样的象限容器(SaO2-A,86.1%±；16.5%)在contralateral眼睛(P<；0.05)。中央容器的氧浸透堵塞容器与那些显示出类似的趋势。在non-ischemicBRVO组，堵塞，中央SaO2-V和SaO2-A没显示出重要变化。在ischemic和non-ischemicBRVO，当时，中央SaO2-A显著地被增加与健康individuals.CONCLUSIONObvious变化在相比堵塞，中央SaO2-A在ischemicBRVO组被发现，显示在小动脉的氧新陈代谢的混乱可以参予ischemicBRVO的致病。

简介：AbstractBone morphogenetic protein belongs to transcription growth factor superfamily β; bone morphogenetic protein signal pathway regulates cell proliferation, differentiation, and apoptosis among different tissues. Cerebrovascular system supplies sufficient oxygen and blood into brain to maintain its normal function. The disorder of cerebrovascular system will result into serious cerebrovascular diseases, which is gradually becoming a major threat to human health in modern society. In recent decades, many studies have revealed the underlying biology and mechanism of bone morphogenetic protein signal pathway played in cerebrovascular system. This review will discuss the relationship between the two aspects, aiming to provide new perspective for non-invasive treatment and basic research of cerebrovascular diseases.

简介：Objective:ToexploreleveldiagnosisonCTandBAincerebrovasculardiseases.Method:CTandBAwereexaminedin53patientswithcerebrovasculardiseasesandcomparedinleveldiagnosis.Result:ThesidesonleveldiagonsisofCTandBAwereidentical.TherangofdiseaseswaslargerinBAthanthatinCT.Conclusion:BAcanhelpleveldiagnosisincerebrovasculardiseases.TheleveldiagnosisofBAandCTwerebasicallyidentical.

简介：Theconnexin43(Cx43)proteins,whichisthepredominantproteinthatcanformgapjunctionsandnon-junctionalhemichannelsinventricularmyocardium,arecentraltothecardioprotectionaffordedbyischemicpreconditioning(IP)andmaybeischemicpostconditioning(PC)too.RecentstudiesshowedthatrecruitmentofCx43tothemitochondriainIPmightplayaroleintheproductionofreactiveoxygenspecies(ROS)thatmediatesIP.ThelocalizationofCx43atmitochondriaappearstobeimportantfortheachievedcardioprotectionandopensanewdoorforustorevealtheexactmechanismsofischemia/reperfusion(I/R)injuryandcardioprotection,anditmightbenewtargetsofpharmacologicalmodulatortoachievedcardioprotection.

简介：Cholesterolcrystalshavelongbeenrecognizedaspartofatheroscleroticplaques.Theyhavebeenvisualizedbylightmicroscopyasemptyspacesorimprintswherecrystalswereoncepresentandthendissolvedbytissueprocessing.Thus,untilnow,theirroleinatherosclerosisandplaquerupturehadbeenconsideredtobeinert.However,bytheprocessingoftissuewithoutethanolitwaspossibletovisualizetheirextensivenessandpotentialroleintissueinjury.Also,itwasdemonstratedthatcholesterolexpandsinvolumewhencrystallizingfromtheliquidtothesolidstate,whichisthepresumedcauseofplaquerupturebysharp-tippedcrystalsgrowingoutoftheplaque'snecroticcore.Specifically,inpatientswhodiedofmyocardialinfarction,allculpritcoronarylesionshadextensivecholesterolcrystalsperforatingthefibrouscapandintima,whilethosepatientswhodiedofothercausesandhadplaquesdidnothavecrystalsperforatingthecapandintima.Additionally,cholesterolcrystalstravelingdownstreamfromtheplaquerupturesitecanscrapetheendotheliumandpromotevasospasm.Moreover,cholesterolcrystalslodgingintothemusclecantriggeraninflammationwithnecrosisindependentofcirculatorycompromiseorischemia.Thesefindingssuggestthatcholesterolcrystalscouldplayacriticalroleinplaquerupture,aswellasvascularandmyocardialinjury.

简介：AbstractBackground:Cerebrovascular disease has become the leading cause of death in China. The purpose of this article is to analyze China's contribution to the interventional treatment of cerebrovascular diseases.Methods:Bibliometric analysis was used for evaluating the quantity, quality, research hotspots, and cooperation network of publications regarding interventional treatment of cerebrovascular diseases from China. These articles were searched from the database of Web of Science Core Collection. The authors, publication years, citation times, regions, and source journals of retrieved articles were recorded. Network analysis and visualization were performed on Citespace5.6.Results:From 1991 to 2019, a total of 5052 articles regarding cerebrovascular intervention were contributed by Chinese researchers. The number of publications from China grew fastest annually in the latest 5 years among countries. These publications were cited 61,216 times, with 12.12 average citations per item. The h-index was 82. Affiliated hospitals of Capital Medical University contributed most articles. Cerebral ischemia and intracranial aneurysm were the most popular keywords over the three decades. The timeline view of keywords indicated that cerebral ischemia always was a hot spot. Stent techniques were the main treatment tools and still had a strong developing trend. Neural regeneration and neuroprotection were the hot topics of basic researches related to cerebrovascular intervention.Conclusions:The number of researches grows rapidly in China over the decades, but the quality still needs further improvement. The increasing contributions of Chinese researchers to the global knowledge system of cerebrovascular intervention are promising.

简介：Onehundredandsixtycasesofsequelaeofcerebrovascularaccident(CVA)wererandomlydividedintothreegroups:Thetemporalpointgroup(TG),58cases;thescalpacupuncturegroup(SG),52cases;thebodyacupuncturegroup(BG),50cases.Itwasshownthatafter30treat-mentsthecurativeeffectsweresignificantlydifferent(P<0.01)amongthethreegroups.TheeffectinTGwasbetterthanthoseinSGandBG.TherewasnodifferenceincurativeeffectsbetweenSGandBG.Itisindicatedthatallthethreeneedlingtechniquescanimproveencephalicbloodflowinpa-tients.Itseemsthattheeffectsofthethreeneedlingtechniquesareasfollows:TG>SG>BG.

简介：目的将在更低的手足讨论ischemic挛缩的功能的重建的方法并且基于它的严厉和预后在更低的手足为ischemic挛缩建议一个分类协议。有在更低的手足的ischemic挛缩的42个病人全部的方法A在这研究被包括。根据骚乱的不同类型和严厉，由神经解压缩组成的外科的重建，腱变长或转移的度，内在的脚肌肉版本和小腿腹胫骨的神经吻合在每个病人被执行。手术后地结果，所有病人能走在扁平的地面上。落下脚在10个病人被改正，并且5个病人仍然在楼梯活动期间感到了一些困难。到屈肌hallucislongus腱的裂口跟腱转移在12个病人被执行，并且他们的走的稳定性被改进。七个病人接受了在5个病人在2个病人和S3到达到S2的ipsilateralsuraltibial神经吻合，和敏感恢复。在更低的手足的结论Ischemic挛缩是在更低的手足损伤以后的破坏复杂并发症。挛缩的预防比确定的挛缩的治疗更重要。到屈肌hallucislongus腱和小腿腹胫骨的神经吻合的裂口跟腱转移，被我们开始实现，能在更低的手足改进ischemic挛缩的功能的恢复，并且因此在更低的手足为ischemic挛缩的功能的重建提供一种新选择。

简介：Onehundredandseventeenacutecerebralinfarctionpatientswererandomlydivid-edintotwogroups:Scalpacupuncturegroup(GroupA)andpuremedicationgroup(GroupB).Thefunctionofthenervoussystem,brainelectricalactivitymappingandsomatosensoryevokedpotentialswereobservedbeforeandafterthetreatment.Itwasfoundthattheindexesinthetwogroupschangedsignificantly(P<0.05).ThecurativeeffectsinGroupAwerebetterthanthatinGroupB(P<0.001).Thecurativeeffectsofscalpacupunctureonacutecerebralinfarctionwereobjectivelyconfirmedbymeansofelectrophysiologicalstudies.

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简介：Ltmedisease(Lymeborreliosis)iscausedbythetick-bornespiro-elraeteBorreliaburgdooCeri.Erythemamigrans,anearlyskinlesion,isthemostcommonclinicalpresentation.Theorganismmayspread,causingvariouslatermanifestations.

简介：春季是传染性疾病的高发时段，预防工作一定要做到及时、有效。也许从下面的短文中我们可以得到一些启示！