Integration of TNF-α signaling: crosstalk between caspasesl,IKK and JNK-中国期刊网

摘要 Theproinflammatorycytokinetumornecrosisfactor-α(TNF-α)regulatesimmuneresponses,inflammationandprogrammedcelldeath.TheultimatefateofacellexposedtoTNF-αisdeterminedbysignalintegrationbetweenitsdownstreameffectors,includingcaspases,IKBkianse(IKK)andc-JunN-terminalproteinkinase(JNK).However,themolecularmechanismsareincompletelyunderstood.Weinvestigatedthisissueusinggeneticandbiochemicalapproaches.WeidentifiedIKKβ,acatalyticsubunitoftheIKKcomplexthatisrequiredforNF-KBactivationandcellsurvivalinresponsetoTNF-α,wasproteolyzedbycasp-3-relatedcaspases.ThisproteolysiseliminatedIKKactivityandpromotedTNF-α,killing.Point

1Wenyan Tian;Fei Teng;Jinping Gao;Chao Gao;Guoyan Liu;Yanfang Zhang;Shizhu Yu;Wei Zhang;Yingmei Wang;Fengxia Xue. Estrogen and insulin synergistically promote endometrial cancer progression via crosstalk between their receptor signaling pathways.肿瘤,2019-01.
2Dan-jun Ma Su-Jun Li Lian-Shui Wang Jie Dai Shi-lin Zhao Rong Zeng. Temporal and spatial profiling of nuclei-associated proteins upon TNF-α/NF-kB signaling.细胞生物学,2009-05.
3Zheng Yong Chen Shulan Dai Shouzhi Liu Zhiquan. The Correlation between TNF-α, IFN-γ, IL-8 and Coronary Heart Disease.心血管疾病,2004-02.
4Toshiyuki Yoneda. Crosstalk between cancer and bone microenvironment in bone metastasis.口腔医学,2008-02.
5Ya-Nan Ma,Shan-Shan Wang,Roman Liebe,Hui-Guo Ding. Crosstalk between hepatic stellate cells and tumor cells in the development of hepatocellular carcinoma.医药卫生,2021-11.
6LihuaWang;XiaohuZhang;WilliamL.Farrar. Transcriptional Crosstalk between Nuclear Receptors and Cytokine Signal Transduction Pathways in Immunity.免疫学,2004-06.
7LAVAL Andy Alain;WU Xiang-hong;LUO Gang;HUANG Wen. Lipopolysaccharide-induced dysregulation of connexin 43 via nuclear factor KB/JNK-dependent signaling.心血管疾病,2013-01.
8Xing Guo;Xiao-Fan Wang. Signaling cross-talk between TGF-β/BMP and other pathways.细胞生物学,2009-01.
9Qunming Wang Liguo Wang Danfeng Liu. Integration of spatial attractions between and within pixels for sub-pixel mapping.物理电子学,2012-02.
10Marco Accorinti. Between Sociological Theory and Professional Practice： Integration Experiences in University Traineeship Programmes.教育学,2016-10.

Integration of TNF-α signaling: crosstalk between caspasesl,IKK and JNK

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Integration of TNF-α signaling: crosstalk between caspasesl,IKK and JNK

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