学科分类
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1 个结果
  • 简介:Theproinflammatorycytokinetumornecrosisfactor-α(TNF-α)regulatesimmuneresponses,inflammationandprogrammedcelldeath.TheultimatefateofacellexposedtoTNF-αisdeterminedbysignalintegrationbetweenitsdownstreameffectors,includingcaspases,IKBkianse(IKK)andc-JunN-terminalproteinkinase(JNK).However,themolecularmechanismsareincompletelyunderstood.Weinvestigatedthisissueusinggeneticandbiochemicalapproaches.WeidentifiedIKKβ,acatalyticsubunitoftheIKKcomplexthatisrequiredforNF-KBactivationandcellsurvivalinresponsetoTNF-α,wasproteolyzedbycasp-3-relatedcaspases.ThisproteolysiseliminatedIKKactivityandpromotedTNF-α,killing.Point

  • 标签: TNF-Α 信号整合 caspase酶 IKK JNK 细胞凋亡