简介：ＡＣＡＳＥＲＥＰＯＲＴＯＦＰＲＩＭＡＲＹＳＱＵＡＭＯＵＳＣＡＲＣＩＮＯＭＡＯＦＴＨＥＥＮＤＯＭＥＴＲＩＵＭＨｅＷｅｎｃｕｉ何文翠；ＷｕＪｉｎｇ吴静；ＣｈａｎｇＪｉｅ唱捷；（ＴｈｅＳｅｃｏｎｄＡｆｆｉｌｉａｔｅｄＨｏｓｐｉｔａｌ，Ｘｉ’ａｎＭｅｄｉｃａ...

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简介：SYPHILISISAchronicsexuallytransmitteddiseasecausedbyTreponumPallidumspreadingtothewholebody.LateSyphiliscanencroachonmostoftheorgans,butearlysyphilishaslessdamagetotheinternalorgans.Hereisacaseofsecondarysyphiliswithliverandkidneyinvolvementreportedasfollows:

简介：Inbiosciencepapers,besidestheotherscientificmisconductissues,replicationofthemethodsectionisacommonproblembecauseduplicationisalwaysbeingdetectedinthesectionMaterialsandMethods.Weeditorsoftenreceivecommentsandqueriesfromauthorswhothinkthatitisamatterofcoursetocopytheirownpublishedmaterialsasopposedtocopyingthoseofothers.Howshouldeditorshandlesuchpaperswithsimilarcontentinthemethodsectionandhowtoguideauthorsinwritingthemethodsectionwithoutbeingaccusedofplagiarism?Whatisright?Whatiswrong?Herewestudiedanexampletoexplainthisproblem.

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简介：Thispaperconsidersaworst-caseinvestmentoptimizationproblemwithdelayforafundmanagerwhoisinacrash-threatenedfinancialmarket.Drivenbyexistingofcapitalinflow/outflowrelatedtohistoryperformance,weinvestigatetheoptimalinvestmentstrategiesundertheworst-casescenarioandthestochasticcontrolframeworkwithdelay.Thefinancialmarketisassumedtobeeitherinanormalstate(crash-free)orinacrashstate.InthenormalstatethepricesofriskyassetsbehaveasgeometricBrownianmotion,andinthecrashstatethepricesofriskyassetssuddenlydropbyacertainrelativeamount,whichinducestoadroppingofthetotalwealthrelativetothatofcrash-freestate.Weobtaintheordinarydifferentialequationssatisfiedbytheoptimalinvestmentstrategiesandtheoptimalvaluefunctionsunderthepowerandexponentialutilities,respectively.Finally,anumericalsimulationisprovidedtoillustratethesensitivityoftheoptimalstrategieswithrespectivetothemodelparameters.

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简介：ＡＤＵＬＴＭＥＳＥＮＣＨＹＭＡＬＨＡＭＡＲＴＯＭＡＯＦＴＨＥＬＩＶＥＲ：ＡＣＡＳＥＲＥＰＯＲＴＷａｎｇＸｉａｎｇｈｕｉ王湘辉ＣｈａｉＦｕｌｕ柴福录ＤｏｎｇＬｉａｎｇ董亮ＬａｎｚｈｏｕＧｅｎｅｒａｌＨｏｓｐｉｔａｌｏｆＰＬＡ，Ｌａｎｚｈｏｕ７３００５０...

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简介：AbstractHarlequin ichthyosis is a severe autosomal recessive skin disorder. Most deaths occur within the first few days after birth, and the survivors still have severe chronic skin disease throughout their lives. Almost all cases were associated with a pathogenic variant of adenosine triphosphate binding cassette transporter, subfamily A, member 12 (ABCA12) gene. We described a case of HI diagnosed by ultrasound examination during the second-trimester and genetic diagnosis reveal two novel heterozygous ABCA12 mutations c.2563-2570delinsGGCAATT, p.(Leu855Glyfs*13), and c.6116delT, p.(Met2039Argfs*8) by the next-generation DNA sequencing, which further enriched our understanding of the pathogenic variation of ABCA12 gene.

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简介：Inversetechniqueisawidelyusedmethodinoceanography,butithasaproblemthattheretrievedsolutionsoftenviolatemodelpriorassumptions.Totunethemodelhasconsistentsolutions,aniterationapproach,whichsuccessivelyutilizestheposteriorstatisticsfornextroundinverseestimation,isintroducedandtestedfromarealcasestudy.Itisfoundthattheconsistencymaybecomeelusiveasthedeterminantsofsolutionandnoisecovariancematricesbecomezerointheiterationprocess.However,afterseveralstepsofsuchoperation,thedifferencebetweenposteriorstatisticsandthemodelprioronescanbegraduallyreduced.