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简介:InternationalJournalofClinicalCaseReports(IJCCR,ISSN1927-579X)isaninternational,openaccess,peerreviewedjournalpublishedonlinebyBioPublisher.Thejournalisconsideringallthelatestandoutstandingresearcharticles,lettersandreviewsinallaspectsofclinicalcase,containingclinicalmedicinewhichadvancegeneralmedicalknowledge;theeventinthecourseofobservingortreatingapatient;newvariationsindiseaseprocesses;aswellastheexpandsthefieldofclinicalrelatingtocasereports.Authorsfromlow-incomecountriesandareasorhavingfinancialdifficultiescanapplythediscountforAPCuponsubmission,andiftheauthorsarequalifiedtobewaivedtheydon’tnecessarilypaytheAPC.Wedonotwantfeestopreventthepublicationofworthy
简介:AbstractIntroduction:Lichen planus pigmentosus inversus (LPPI) is a rare a rare variant of lichen planus characterized by hyperpigmented patches with predominating localization in intertriginous areas. Due to its rarity, only a few LPPI cases are reported. We herein describe two rare cases of LPPI.Case presentation:The two patients were all with a brownish macular lesion on the intertriginous area. A diagnosis of LPPI was made based on their clinical manifestations, dermoscopic features, and histopathologic features, which revealed an interface change, lichenoid infiltration, and pigmentary incontinence.Discussion:LPPI is pruritic or asymptomatic, hyperpigmented macules and patches on the flexural folds. The axillae and flanks were the most commonly affected areas, followed by the groin and genitalia. About half of the female patients had inframammary fold lesions. LPPI shows higher female predominance than Lichen planus pigmentosus. There were fewer cases that lasted more than 3 years compared to LPP.Conclusion:LPPI is a rare variant of lichen planus, with a locational characteristic and female predominance. Therefore, in the case of a pigmented disease occurring in the flexural folds, it should be placed in the differential diagnosis.
简介:Amongthevariousdiagnosticmodalitiesforsmallbowelhemangioma,videocapsuleendoscopy(VCE)anddouble-balloonenteroscopy(BE)canberecommendedaspartofthework-upinpatientswithobscuregastrointestinalbleeding(OGIB).BEissuperiortoVCEintheaccuracyofdiagnosisandtherapeuticpotential,whileinmostcasestotalenteroscopycannotbeachievedthroughonlytheantegradeorretrogradeBEprocedures.Astreatmentforsmallbowelbleeding,especiallyspoutbleeding,localizationofthelesionforthedecisionofBEinsertionfacilitatesearlytreatment,suchasendoscopichemostaticclipping,allowingpatientstoavoiduselesstransfusionandtheworseningoftheirdiseaseintolife-threateningstatus.ApplyingendoscopicIndiainkmarkingpriortolaparoscopicsurgicalresectionisaparticularlyusefultechniqueformoreminimallyinvasivetreatment.WereporttwocasesofsmallbowelhemangiomafoundinexaminationsforOGIBthatweretreatedwithcombinationoflaparoscopicandendoscopicmodalities.
简介:THEDEVELOPMENTOFEGYPTOLOGYINCHINAThefirstEgyptologistinChinawasprofessorXiaNai(1910-1985).In1935,XiaNaigraduatedfromQinghuaUniversityinChinaandwenttostudyEgyptologyatUniversityCollegeLondon.In1937,hetraveledtotheNearEastandEgyptandparticipatedintheexcavationsinArment(Egypt)andTellDuweir(Palestine).In1941,XiaNaireceivedhisPhDinEgyptianArchaeology(notofficiallyawarded
简介:Themanagementofcastrate-resistantprostatecancerprogressingaftermaximumandrogenblockade(MAB)hasevolvedinthelastdecadewiththedevelopmentofseveralnoveltherapeuticoptions.However,theinitialtherapeuticstrategyinthesepatientsusuallyinvolveswithdrawalofanti-androgenthatcanbeassociatedwithbiochemicalresponseinapproximately20%ofpatients.Notably,wehaveobservedevidenceofsustainedbiochemicalresponseintwopatientsfollowingsecondandthird-lineMABusingrechallengescheduleofpreviouslyadministeredanti-androgenafterlatentinterval.ThepossibilityofresponsefollowingsequentialMABusingthesameanti-androgenagenthasnotyetbeenreported.
简介:Molecularsubtypingofbreastcancermayprovideadditionalprognosticinformationregardingpatientoutcome.Theepidermalgrowthfactorreceptor(HER2)overexpressingbreastcancersaredesignatedasHER2-postive(HER2+)breastcancerandcarryaparticularlyunfavorableprognosis.WepresenttwocasesofHER2-postivemetastaticbreastcancer(MBC)whoarefoundtobeachallengetotreat,especiallyduetotheoccurrenceofbrainmetastasis.Trastuzumab-basedtherapyimprovesclinicaloutcomes,evenifthepatienthasundergonemulti-linetreatment.ThesecasereportsalsoemphasizetheimportanceofretestingHER2statusbecauseitcanbediscordanceinreceptorstatusbetweenprimaryandrecurrentbreastcancer.
简介:摘要IntroductionDelayed encephalopathy due to carbon monoxide (CO) poisoning can even occur in patients with mild symptoms of acute CO poisoning. Some cases taking conventional hyperbaric oxygen (HBO) therapy or steroid-pulse therapy may be insufficient, and AchEI may be effective.Patient concerns and diagnosesWe report two cases of delayed encephalopathy after acute CO poisoning involving two women aged 69 (Case 1) and 60 years (Case 2) whose cognitive function improved with acetylcholinesterase inhibitor (AchEI) treatment. Delayed encephalopathy occurred 25 and 35 days after acute CO poisoning in Case 1 and Case 2, respectively. Both patients demonstrated cognitive impairment, apathy, and hypokinesia on admission.Interventions and outcomesAlthough hyperbaric oxygen therapy did not yield any significant improvements, cognitive dysfunction improved substantially. This was evidenced by an improved Mini-Mental State Examination score from 9 to 28 points in Case 1 and an improved Hasegawa′s dementia rating scale score from 4 to 25 points in Case 2 after administration of an AchEI. In Case 1, we administered galantamine hydrobromide, which was related with improved white matter lesions initially detected on brain magnetic resonance imaging. However, in Case 2 white matter lesions persisted despite AchEI treatment. AchEI treatment may result in improved cognitive and frontal lobe function by increasing low acetylcholine concentrations in the hippocampus and frontal lobe caused by decreased nicotinic acetylcholine receptor levels in delayed encephalopathy after CO poisoning.ConclusionPhysicians should consider AchEIs for patients demonstrating delayed encephalopathy due to CO poisoning.
简介:幼苗ofLarixleptolepis上的spayingPenzhangjing的实验被进行一年。分别地,在试验性的幼苗的脚的高度生长和直径与控制幼苗相比增加了34.3%和35.5%。变化分析断定Penzhangjing在幼苗的脚在高度和直径的生长上有明显的效果。