简介：Aftercapacityexpansionofsomehydroturbines,suchabnormalitiesashightemperatureofthebearing,vibrationofunits,frictionnoiseandsoon,couldbesolvedbyqualifiedinstallation,removingthediversioncrossaddedatthedrafttube,anduseofnewrunner,etc.

简介：精子是导出把父亲的单倍体染色体送到卵母细胞的一种高度专业化的房间类型。渐成说，或基因规章，精子的性质和机制在父亲的染色体的准备帮助贡献胚胎开始和接合子的染色体。许多最近的研究在精子处理了改变的渐成说过程的问题。这评论评估DNA损坏，染色体非整倍性，减少的端粒长度，中心体的畸形性，印错误的genomic，改变的mRNA侧面，并且在胚胎开始上的在授精和观察效果以前的在精子的反常原子包装的当前的理解。注意也被给了在人与改变的渐成说机制理解精子的内在的病原学。

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简介：AbstractSepsis remains one of the leading causes of death globally, in spite of advanced developments in intensive care and better understandings of pathophysiology related to sepsis. There is no special treatment or drug available for sepsis, currently. Under normal circumstances, neutrophil is a major player in acute infection control. However, during sepsis, the migration abilities and antimicrobial functions of neutrophils are impaired, resulting in a dysregulated immune response. Recent studies have indeed demonstrated that blocking or reversing neutrophil migration and impaired antibacterial function can improve the outcomes in septic animal models. This article systemically synthesized information regarding related factors and signaling involved in the functions of neutrophils in sepsis. This review also discussed the possibility that neutrophils be used as a marker for specific diagnosis and/or prediction of the outcomes of sepsis.

简介：Objective::Toexplorethevalueofacombinedcomputedtomography(CT)andmagneticresonanceimaging(MRI)inevaluatingprofoundsensorineuraldeafnesspatientsbeforecochlearimplant(CI)surgery.Methods:Aretrospectiveanalysisof1012casesofprofoundsensorineuraldeafnessthatreceivedCIwasperformed.Results:Atotalof96caseswerediagnosedwithinnerearabnormalitiesincludinglargevestibularaqueductsyndrome(LVAS,n?61),Micheldeformity(n?3),cochlearincompletepartitionI(n?2),cochlearincompletepartitionII(n?6),cochlearhypoplasiawithvestibularmalformation(n?3),cochlearossification(n?3),bilateralinternalauditorycanalobstruction(n?5)andinternalauditorycanalstenosis(n?2).Conclusion:HighresolutionCT(HRCT)candisplaybonystructureswhileMRIcanimagethemembranouslabyrinthinpreoperativeevaluationforcochlearimplantation.Thecombinationofthesetwomodalitiesprovidesreliableanatomicalinformationregardingthebonyandmembranouslabyrinths,aswellastheauditorynerve.

简介：ThemuscleproteinmyosinbindingproteinC(MyBPC)isalargemulti-domainproteinwhoseroleinthesarcomereiscomplexandnotyetfullyunderstood.MutationsinMyBPCarestronglyassociatedwiththeheartdiseasefamilialhypertrophiccardiomyopathy(FHC)andtheseexperimentsofnaturehaveprovidedsomeinsightintotheintricateworkingsofthisproteinintheheart.WhilesomeregionsoftheMyBPCmoleculehavebeenassignedafunctionintheregulationofmusclecontraction,theinteractionofotherregionswithvariouspartsofthemyosinmoleculeandthesarcomericproteins,actinandtitin,remainobscure.Inadditicn,severalintra-domaininteractionsbetweenadjacentMyBPCmoleculeshavebeenidentified.Althoughthebasicstructureofthemolecule(aseriesofimmunoglobulinandfibronectindomains)hasbeenelucidated,theassemblyofMyBPCinthesarcomereisatopicfordebate.ByanalysingtheMyBPCsequencewithrespecttoFHC-causingmutationsitispossibletoidentifyindividualresiduesorregionsofeachdomainthatmaybeimportanteitherforbindingorregulation.Thisreviewlooksatthecurrentliterature,inconcertwithalignmentsandthestructuralmodelsofMyBPC,inanattempttounderstandhowFHCmutationsmayleadtothediseasestate.

简介：AbstractAdenotonsillectomy is one of the most common surgical procedures performed by otolaryngologists. It is vital that surgeons are aware of the risks in performing this surgery especially during the COVID-19 pandemic and in children with hematologic disorders. In this review we describe common hematologic disorders often noted in pediatric patients undergoing this procedure, as well as proper screening and management of these patients. In addition, we also address the impact of the COVID-19 pandemic and some measures to help mitigate the risks of this procedure during this time.

简介：精子disomy的层次相关到不孕的层次，现在是众所周知的(象另外的因素一样)。永久维持aneuploidy到经历intracytoplasmic精子注射(ICSI)的不肥沃的男性的后代的风险在帮助复制成为了一个暑热地辩论的问题；然而，在那里仍然是障碍到为精子提供在一个临床的背景屏蔽的disomy的实际实现。主要障碍是花到分析的操作员时间一统计上有意义(足够)房间的数字。“自动化点数”的介绍软件鈥揾ardware联合介绍一个潜在的解决方案给这个问题。在这初步的确认研究，我们分析了10个病人，手工地并且用一个商业地可得到的点阻止。结果显示出在两条途径之间的统计上重要的关联因为当为双精子得分时，精子disomy，而是没有关联得分被发现。对后者的最可能的解释作为一个单个双房间是二个仔细联系的精子头的明显的overscoring。这些结果，和将续起的类似的进一步的研究，通知费用鈥揵enefit的帮助分析那单个诊所需要执行以便决定是否采用从要求ICSI治疗的人为对精子的评价作为一个平淡的工具屏蔽的精子aneuploidy。

简介：AbstractObjective:Few reports have described intracranial hemangiomas and structural brain and/or arterial anomalies in patients with infantile hemangiomas. This study was performed to examine the magnetic resonance imaging findings of intracranial abnormalities in a group of infants with hemangiomas in the head and neck regions.Methods:We reviewed our hemangioma treatment center database from January 2010 to July 2018 to assess the prevalence of intracranial abnormalities in infants with hemangiomas in the head and neck regions. Clinical and electronic magnetic resonance imaging data were also retrieved from the patients’ medical charts.Results:Of 436 patients with infantile hemangiomas in the head and neck regions, 23 (5%) had intracranial abnormalities, including 20 (23%) with segmental hemangiomas and 3 (1 %) with focal hemangiomas. In total, 14 patients had intracranial hemangiomas located within the ventricle and cisterns or ipsilateral lesions involving the extradural space. Eight patients had intracranial structural abnormalities, such as cerebellar dysplasia, Dandy-Walker malformation, and hydrocephalus. Five patients had intracranial arterial anomalies, and three patients had arteriovenous malformations.Conclusions:These findings support the hypothesis that intracranial hemangiomas are commonly associated with segmental infantile hemangiomas in the head and neck regions.

简介：Objective:Toassessthecardiovascularabnormalitiesinpatientswithspontaneoussubarachnoidhemorrhage(SAH).Methods:AllpatientsadmittedtoourinstitutionwithaprimarydiagnosisofspontaneousSAHandhadatransthoracicechocardiogram(TTE)performedfrom1stofJuly2011until30thofMay2014wereenrolled.Results:Outof2058patientsadmittedtoourinstitutionwithadiagnosisofSAH,overathreeyearperiod,only244patients(12%)hadTTEperformedduringtheindexhospitalization.Inthisselectedcohort,themeanagewas59yearsand66%ofpatientswerefemale.ElevatedtroponinTwasnoticedin37%ofpatientsandQTcprolongationwasthecommonestECGabnormalityoccurringin49%ofthepatients.Thirtyninepatients(16%)hadarestingsegmentalwallmotionabnormalityontheTTE,includingfivepatientswithapicalballooning.In-hospitalmortalitywas15.6%(38patients).Conclusion:CardiovascularabnormalitiesinselectedpatientswithSAHwhohadcardiacultrasoundarerelativelycommon;howevertheincidenceofventricularballooningislow.InordertoattainthecorrectincidenceofcardiovascularabnormalitiesinSAHpatients,allpatientsadmittedwithSAHshouldundergoTTEandhaveECGandcardiacmarkerscheckedduringtheirhospitalization.

简介：BACKGROUND:Thepathwaysinduced/activatedbymercurypoisoningthatleadtomusclepainremainunclear.Thepresentstudyaddressedthestructuralchangesobservedintheperipheralnervefollowingmercurypoisoning.OBJECTIVE:Toestablishthemercurypoisonratmodel,ratswereintragastricallyadministeredmercury.Thecorrelationbetweenpost-mercurypoison-inducedmuscularpainandtibialnervemorphologicalchangeswereobserved.DESIGN:Observationalcontrastanimalstudy.SETTING:ShangdongAcademyofOccupationalHealthandOccupationalMedicine.MATERIALS:ThirtyadultSpragueDawleyratsofequalgender.Mercurychloride(HgCl2,analyticalgrade:99.99%;batchnumber:990402)wasprovidedbyShanghaiChemicalReagentFactory,andsodiumdimercaptopropanesulfonate(DMPS)injectionbyShanghaiHarvestPharmaceuticalCo.,Ltd.(batchnumber:0309011).METHODS:ThisstudywasperformedattheAnimalExperimentalCenterofShangdongAcademyofOccupationalHealthandOccupationalMedicinefromDecember2005toJanuary2006.Ratswererandomlydividedintohigh-dosemercury,low-dosemercury,andcontrolgroups,with10ratsineachgroup.Ratsinthetwomercurygroupswereintragastricallyadministered17mg/kgand8.5mg/kgHgCl2solution,respectively,onceadaytoestablisharatmodelofsubacutemercurypoisoning.Ratsinthecontrolgroupwereintragastricallyadministered2mLsaline,onceaday.Intragastricadministrationinthethreegroupslastedfor(20±2)days.Aftermodelestablishment,ratsinthetwomercurygroupswereinjectedDMPSonceadaytoremovemercury.Theinjectionlastedfor3daysafterevery4-dayinterval.Sevendayswasregardedasonetreatmentcycle,andthereweretwotreatmentcyclesintotal.MAINOUTCOMEMEASURES:Mercury-inducedmuscularpainstatus;ultrastructuralchangesoftherighttibialnervefollowingmodelestablishmentandmercuryremovalundertransmissionelectronmicroscope.RESULTS:Thirtyratswereincludedinthefinalanalysis.Muscularpainsta

简介：AbstractObjective:Structural abnormalities and dysfunction of the placenta contribute to pregnancy-related complications, such as preeclampsia. Syncytin-A (synA) has been reported to be expressed in the placenta. The contribution of synA to developmental abnormalities and dysfunction of the placenta remains elusive. In this study, we aimed to explore the role of synA in placental development and functions.Methods:SynA-knockout mice were generated using the CRISPR-Cas9 method, and the phenotypes of the placenta and fetus of synA-knockout mice were observed. Real-time quantitative polymerase chain reaction (PCR) and routine PCR were employed to detect the genotypes of the offspring. CD31 immunohistochemistry was used to evaluate the vessel density of the placenta, and the protein levels of key molecules were measured by western blotting.Results:SynA knockout caused fetal death. Furthermore, synA-knockout mice showed placental developmental abnormalities, indicated by a thinner labyrinth layer, thicker spongiotrophoblast layer, lower blood vessel density, and significantly higher numbers of apoptotic trophoblasts, when compared with wild-type littermates. Mechanistically, synA ablation induced apoptosis-inducing factor (AIF) cleavage and nuclear localization and promoted placental trophoblast apoptosis. In addition, synA knockout increased the calpain1 protein levels. The calpain1 inhibitor calpeptin blocked synA knockout-induced AIF cleavage, partially restoring the placental structural abnormalities of synA-knockout mice.Conclusions:SynA knockout leads to placental developmental abnormalities by inducing trophoblastic apoptosis via the calpain1-AIF pathway.

简介：摘要：目的：本文对超声心动图在冠心病节段性室壁运动异常评价中的应用效果进行分析。方法：文章选取2021年7月至2022年7月该时间段本院接收的冠心病患者80例，均采用超声心动图和冠状动脉造影术对患者是否存在节段性室壁运动异常的情况进行观察，并对其检查的结果进行汇总及分析。结果：研究结果显示，使用超声心动图的方式对该类患者进行诊断的精准度、灵敏度、特异度、阴性预测值、阳性预测值等均有明显的提升，在对其研究结果进行检验后发现，超声心动图的诊断结果与患者阶段性室壁运动异常的结果一致，且在对选取的患者诊断过程中不良反应的发生率更少。所选患者的研究数据均存在明显的差异，可确保本次研究数据的可靠性。结论：超声心动图对该类患者的诊断价值更高，且具有较强的安全性，对于患者的检查更有意义。