简介:AIM:Toinvestigatethepossiblerelationshipbetweentheinfluencingfactorsoccurringbeforeandduringbirthinfull-terminfantsandtheoutcomeofretinopathy.·METHODS:Totally816full-terminfantsadmittedintheneonateintensiveunitofBoaiHospitalofZhongshanbetween1May,2008and30June,2011wereincludedinthestudy.Fundusexaminationwasperformedandevaluatedindividuallyonthemattheageof48hoursafterdelivery,2weeksand1month.Somepossibleriskfactorshappeningprenatallyorduringdeliverysuchaspregnantrelatedhypertension,placentaprevia,placentalabruptionetc,aswellassomeneonatalriskfactorssuchasneonatalasphyxia,hypoxic-ischemicencephalopathy(HIE),lowbirthweightetc,wererecordedandevacuated.Thentheeffectoftheriskfactorsoffull-terminfantsonretinopathywasstudied.·RESULTS:Theincidenceofretinalhemorrhageoffull-terminfantswithprenatalpregnantrelatedhypertension(PRH)ofthemother(43.6%)wassignificantlyhigherthanthatoffull-terminfantswithout(8.0%).(P<0.001).Theincidenceofretinalhemorrhageoffull-terminfantswithneonatalasphyxiaand/orhypoxic-ischemicencephalopathy(HIE)(29.3%)wassignificantlyhigherthanthatofthosewithout(15.7%),butcorrelationwasnotfoundbetweentheseverityofretinahemorrhageandthedegreeofhypoxicdisease.Apalecolorofopticdiscwasassociatedwithalowbirthweightoffull-terminfant.Full-terminfantswithbirthweighlessthan2500ghadasignificanthigherincidenceofretinopathythanthosewithbirthweightequalormorethan2500g(P<0.001).·CONCLUSION:Themaininfluencingfactorswhichleadtoretinopathyofhighriskfull-terminfantsareprenatalfactorssuchasPRH,andsomeneonatalriskfactorssuchasasphyxia,hypoxic-ischemicencephalopathy,andlowbirthweight.
简介:目的分析常年性变应性鼻炎的狗、猫上皮变应原皮肤点刺试验的阳性结果,对其他气传变应原的反应性,并进一步探讨环境接触与其相关性。方法总结1022例常年性变应性鼻炎患者采用阿罗格叶7种气传变应原标准化试液进行的皮肤点刺试验;分析狗、猫上皮变应原的皮试结果及合并其他气传变应原阳性的比例;并根据是否有环境接触分类,比较各组在阳性率分布上的差异。结果常年性变应性鼻炎中狗上皮变应原皮试阳性占13.80%,猫上皮阳性占6.95%;且98%以上合并其他气传变应原阳性,尤以合并粉尘螨、屋尘螨阳性居多。其中21.93%和26.32%环境接触狗/猫的变应性鼻炎相应狗/猫上皮变应原皮试阳性;无环境接触组的阳性率分别为12.78%和6.58%,差异均有统计学意义(P〈0.01)。结论常年性变应性鼻炎的狗上皮及猫上皮的阳性率位居前列,其中绝大多数合并其他气传变应原阳性。鉴于环境接触对狗、猫上皮过敏的高危险性,变应性鼻炎患者应该尽可能地避免饲养、接触宠物。
简介:目的:探讨糖皮质激素的使用是否是中心性浆液性脉络膜视网膜病变(centralserouschoriorelinopathy,CSCR)发病的危险因子。方法:前瞻性病例对照研究。对连续的100例急性CSCR患者就糖皮质激素的使用状况进行问卷调查。从同期就诊的非CSCR的门诊患者中根据年龄和性别选择病例与之匹配,以建立对照组,并进行相同的问卷回答。结果:在100例CSCR患者中,10例(10%)有激素使用史,男4例,女6例。而100例对照患者中仅有3例(3%)有激素使用史,男2例,女1例。两组之间有显著性差异。结论:通过前瞻性的病例对照研究,我们发现使用糖皮质激素是CSCR发病的危险因子。
简介:AIM:Toexaminetheα-Galgeneexpressionanddistributioninthedifferentspecies/genusanddevelopingphaseanimalocularsurfacetissue.METHODS:α-Galbindingassaywerecarriedoutonvariousanimaleyesections.Photograph,slit-lampobservationonvariouseyeshowednormalcornealtransparence.RESULTS:Astrongα-Galexpressionininvertebratesandsomevertebratesoculartissue,butnoα-Galbindinginbirds,fishandmammal.α-Galexpressionchangeinthedevelopmentofmiceocularsurfacetissue(exceptsclera)anddisplaygenusdependencyinthedifferentmurineocularsurfacetissue.CONCLUSION:Thisstudyidentifiedspecificα-Galepitopesbindingareaintheocularsurfaceofseveralspeciesandmaysolvetheproblemthatnaiveocularsurfacemaybeusedasnaturalα-Galgeneknockoutmodel/highriskimmunologicrejectionmodelorocularsurfacescaffoldmaterial.
简介:研究显示,趋化因子受体3(chemokinereceptor3,CCR3)在眼部主要分布于视网膜色素上皮细胞中,亦表达于脉络膜血管内皮细胞(CECs)中。CCR3的特异性高表达在湿性年龄相关性黄斑变性(age-relatedmaculardegeneration,AMD)中被发现,并被证明在湿性AMD患者脉络膜新生血管(choroidalneovascularization,CNV)的产生中具有重要作用。本文拟对CCR3的结构、功能、目前研究存在的问题及未来的研究方向做一综述。相信随着对CCR3研究的进一步深入,必将帮助我们寻找到一种湿性AMD诊断和治疗的新方法,同时也可能对其它CNV性疾病研究以及新的抗CNV药物提供重要参考。
简介:目的本文报道了12例同时性多灶性喉癌并通过分析其临床病理学特点,探讨多灶性喉癌的发生学来源.方法回顾性分析1991~2001年间我院行全喉切除术的12例同时性多灶性喉癌的TNM分期、肿瘤位置、大小、组织学类型、病理学分级以及病史等.结果同时性多灶性喉癌的发病率是1.4%(12/861).所有病理均为鳞状细胞癌.同一病例各病灶的组织学类型和病理学分级均相同.二病灶喉癌的发生率占总数的91.7%(11/12),仅一例为三病灶喉癌、67%(8/12)患者中二病灶分别位于双声带游离缘的对应处.3例(25%)有术前放疗史,1例术前曾行多次声带活检为不典型增生.所有病例术前均未诊断出多灶性.结论声门型同时性多灶性喉癌可能为单中心起源.腔内种植即声带振动时癌细胞从一侧声带游离缘种植到对侧接触损伤处,可能是喉癌多灶性的原因之一,放疗可能是多灶性喉癌的诱发因素.
简介:目的:探讨白内障手术切口大小对矫正角膜原有散光、泪膜稳定性的影响。方法:收集我院2014-07/2016-07接诊的白内障患者92例92眼,随机分为对照组和观察组,各46例46眼。两组均行透明角膜隧道切口白内障乳化超声术联合折叠人工晶状体植入术,对照组为3.0mm透明角膜切口,观察组为1.8mm透明角膜切口。检测术前及术后1d,1wk,1、3mo裸眼视力、角膜散光度、基础泪液分泌(schirmerⅠtest,SⅠt)、泪膜破裂时间(break-uptime,BUT),记录术后1d,1wk,1、3mo术源性散光(surgeryinducedastigmatism,SIA)。结果:两组术后1、3mo裸眼视力与术前比较差异有统计学意义(P〈0.05),但两组手术前后不同时间比较差异无统计学意义(P〉0.05);两组术后1、3mo角膜散光与术前比较无明显变化,差异有统计学意义(P〈0.05),两组手术前后各时间点比较差异无统计学意义(P〉0.05);两组术后1wk,1、3moSIA均不断减小,且观察组术后1d,1wk,1moSIA明显低于对照组,差异有统计学意义(P〈0.05)。两组术后1wkSⅠt、BUT少于术前,差异有统计学意义(P〈0.05),术后1、3mo与术前比较差异无统计学意义(P〉0.05);观察组术后1wkSⅠt、BUT高于对照组,差异有统计学意义(P〈0.05),但术后1、3mo比较,差异无统计学意义(P〉0.05)。结论:与3.0mm标准切口相比,1.8mm透明角膜切口可减少SIA,缩短角膜稳定性恢复时间。
简介:AIM:Toadaptthelowvision-relatedqualityoflife(LVQOL)instrumentintoTurkishlanguageandtoassessitsvalidityandreliability.METHODS:Thestudywasconductedin387patientsattendingtheCentreofLowVisionRehabilitation,FacultyofMedicine,AnkaraUniversity.Forstatisticalanalyses,theSpearman’scorrelationcoefficient,Cronbach’salphacoefficientandConfirmatoryFactorAnalysis(CFA)wereused.RESULTS:AccordingtoresultsofCFA,theiteminthe'Adjustment'subscalebecauseofhavingthefactorloadingbelow0.40,wasexcludedfromthequestionnaire.ThereliabilityofthequestionnairewasassessedaccordingtoCronbach’salphacoefficients.Thereliabilityofthe'DistanceVision,Mobility,andLighting'subscalewas?琢=0.863;ofthe'Adjustment'subscalewas?琢=0.694;'ReadingandFineWork'was?琢=0.791,and'ActivitiesofDailyLiving'was?琢=0.770.Sotheseresultsindicatethatthequestionnaireisreliabletomeasurethevisionrelatedqualityoflifeoflow-visionpatients.Thecorrelationsbetweenthesubscaleswerealsoanalyzed,andthecorrelationbetween'Adjustment'and'ReadingandFineWork'wasfoundtobethelowest(rs=0.336,P<0.001),whereasthestrongestcorrelationwasfoundbetweenthe'ReadingandFineWork',and'ActivitiesofDailyLiving'.Additionally,the'Adjustment'dimensionshowedthestrongestcorrelationwithonly'DistanceVision,Mobility,andLighting'dimension.CONCLUSION:Afterremovingthelastitemintheseconddimension,theTurkishadaptationofalldimensionsoftheLVQOLhasbeenshowntobereliable,validandsuitableforuseinpatientswithlowvisioninTurkey.
简介:AIM:TopresenttheresultsofimplantationofIakymenkokeratoprosthesisinfivepatientswithvascularizedcornealleukomacausedbysevereocularinjury.·METHODS:Iakymenkokeratoprosthesiswasimplantedinto5eyesof5patients:4patientsweresufferedfromchemicalburnsand1patientfromexplosiveinjury.Thepreoperativevisualacuityrangedfromlightperceptiontohandmotion.Theimplantationsurgerywascomposedoftwo-stageprocedures.Thefollow-upperiodwasfrom9monthsto11years.Theoutcomemeasureswerevisualacuity,retention,andcomplicationsofthekeratoprosthesis.·RESULTS:Visionimprovementswereachievedinmostpatients.Allkeratoprosthesiswereretainedwithinthefollow-upperiod.Cornealmeltingoccurredinonepatientandfibrousclosureinanotherpatient,bothofwhichweresuccessfullytreated.Retinaldetachmentoccurredinonepatientaftersurgery.·CONCLUSION:Iakymenkokeratoprosthesisseemstobeapromisingalternativeforthepatientswithseverecornealinjury,butfurtherinvestigationisneededtoevaluatetheroleofIakymenkokeratoprosthesis.