Optimizing CT for the evaluation of vestibular aqueduct enlargement:Inter-rater reproducibility and predictive value of reformatted CT measurements

(整期优先)网络出版时间:2015-01-11
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Enlargedvestibularaqueduct(EVA),themostfrequentidentifiablecauseofcongenitalhearingloss,isevaluatedwithhigh-definitionmultidetectorCTintheaxialplane.OurpurposewastodeterminewhichreformattedCTmeasurementsaremostreproducible.Sevenmultiplanarreformattedimageswerecreatedforeachofthe64temporalbonesinpatientswithEVA.Intraclasscorrelationcoefficients(ICC)wereusedtoassessinter-observervariability,andbothlinearregressionandROCanalyseswereusedtocomparethemeasurementswithseverityofhearingloss,asassessedbypuretoneaudiometry.Allsevenmeasurementshadexcellentinter-observervariability,withaverage-measureICCrangingfrom0.92to0.98.Therewasnostatisticallysignificantcorrelationbetweentheradiologicdegreeofaqueductenlargementandseverityofhearinglossusinganyofthesevenmeasurements;ROCanalysesrevealedareasunderthecurvesrangingfrom0.57to0.73.Optimalaccuracywasobtainedwithathresholdof1.75mmasmeasuredattheaqueductalapertureintheP€oschlplane,withsensitivityof0.75andspecificityof0.63.AlthoughtheradiologicmeasurementmaynotserveasareliabletoolforassessingseverityofEVA,P€oschlplanereformattinghasproventobebetterthanconventionalaxialacquisitionplaneforidentifyingpatientswithclinicallysignificanthearingloss.