摘要
Noisepollutionisamajorhazardousfactortohumanhealthandislikelyharmfulforvulnerablegroupssuchaspre-terminfantsunderlifesupportsysteminanintensivecareunit.Previousstudieshavesuggestedthatnoiseexposureimpairschildren’slearningabilityandcognitiveperformanceandcognitivefunctionsinanimalmodelsinwhichtheeffectismainlyattributedtotheoxidantstressofnoiseonthecognitivebrain.Thepotentialroleofnoiseinducedhearingloss(NIHL),ratherthantheoxidantstress,hasalsobeenindicatedbyadepressionofneurogenesisinthehippocampuslongafterabriefnoiseexposure,whichproducesonlyatentativeoxidantstress.ItisnotclearifnoiseexposureandNIHLduringearlydevelopmentexertsalongtermimpactoncognitivefunctionandneurogenesistowardsadulthood.Inthepresentstudy,abriefnoiseexposureathighsoundlevelwasperformedinneonatalC57BL/6Jmice(15daysafterbirth)toproduceasignificantamountofpermanenthearinglossasproved2monthsafterthenoise.Atthisage,thenoise-exposedanimalsshoweddeterioratedspatiallearningandmemoryabilitiesandareductionofhippocampalneurogenesisascomparedwiththecontrol.Theaveragedhearingthresholdwasfoundtobestronglycorrelatedwiththescoresforspatiallearningandmemory.Weconsidertheeffectsobservedarelargelyduetothelossofhearingsensitivity,ratherthantheoxidantstress,duetothelongintervalbetweennoiseexposureandtheobservations.
出版日期
2015年01月11日（中国期刊网平台首次上网日期，不代表论文的发表时间）
