Marineecologicalnicheshaverecentlybeendescribedas"particularlypromising"sourcesforsearchofnewantimicrobialstocombatantibiotic-resistantstrainsofpathogenicmicroorganisms.Marineorganismsareexcellentsourcesformanyindustrialproducts,buttheyarepartlyexplored.Over30000compoundshavebeenisolatedfrommarinesources.Bacteria,fungi,andcyanobacteriaobtainedfromvariousmarinesourcessecretseveralindustriallyusefulbioactivecompounds,possessingantibacterial,antifungal,andantimycobacterialactivities.Sustainablecultivationmethodsforpromisingmarineorganismsandbiotechnologicalprocessesforselectedcompoundscanbedeveloped,alongwiththeestablishmentofbiosensorsformonitoringthetargetcompounds.Thesemisyntheticmodificationsofmarine-basedbioactivecompoundsproducetheirnewderivatives,structuralanalogsandmimeticsthatcouldserveasnovelleadcompoundsagainstresistantpathogens.Thepresentreviewfocusesonpromisingantimicrobialcompoundsisolatedfrommarinemicrobesfrom1991-2013.
