简介：Coastallowlandshavelargeareasofhazardimpactandrelativelylowcapacityofpreventiontothewaterrelatedhazards,whichhavebeenindicatedbythewide-spreadfloodhazards,highpercentagesoflandwithhighfloodvulnerability.Increasingpopulationpressureandtheshiftofresourcesexploitationfromlandtoseawillforcemoreandmorecoastallowlandstobedevelopedinthefuture,furtherenhancingthedangerofwater-relatedhazards.Inthispaper,thecoastallowlandsinthenorthernJiangsuprovince,China,wereselectedasacasestudy.TheInterpretationStructuralModel(ISM)wasemployedtoanalyzethedirectandindirectimpactsamongtheelementswithinthesystem,andthereby,toidentifythecausalelements,middlelinkages,theirexpressions,andrelations.

简介：UndergroundprospectingwithintheLubin-Sieroszowiceminingareawhichtookplaceduringlast5years,ledtoadiscoveryofanewtypeofAu,PtandPdmineralisationlocated0-0.5mbelowthecopper-silverorebodyinthesouth-westernpartofthePolishPermianBasin.Thegold-bearingzoneliesmainlyintheWeissliegendessandstone(IowerPermian),butlocallytransgressesthestratigraphicsequenceintotheoverlyingkupferschieferandWerralimestone(Zechstein).

简介：Objectives:ToprovidereferencesforHIV/AIDS-re-latedhealtheducationstrategiesthroughsurveyonHIV/AIDS-relatedknowledge,attitudeanddetermi-nantsofHIV/AIDSawareness.Methods:Thestudysubjectswereselectedbyran-dominterceptioninadowntownstreetofGuangzhoucityonWorldAIDSDay-December1,2002.Theuni-formquestionnaireswerefinishedbymeansofself-administration.Results:Twohundredquestionnairesweredistrib-utedand147qualifiedquestionnaireswerecollected.Theresultsshowed,theawarenessrateofHIV/AIDS-relatedknowledgewas63.3%,andawarenessrateoftransmissionrouteswas76.2%,whilstnon-transmis-sionroutewas60.5%;theawarenessrateoftrans-missionwas59.2%;theawarenessrateofpreventionwas47.0%;thepositiveattitudetopeoplelivingwithHIV/AIDSwas65.6%.MultiplevariableLogisticre-gressionanalysisshowedthedeterminantsofHIV/AIDS-relatedknowledgewereeducationlevel,age,maritalstatusandgender,ofwhichpeoplewithhighlevelofeducation,youngageandthegroupofmaleandmarriedhadbetterawarenessofHIV/AIDS.Conclusion:CurrentHIV/AIDS-relatedknowledgeofurbanresidentsisrelativlylow,especiallyforthenon-transmissionroute,hencefurtherHIV/AIDS-re-latededucationshouldbestrengthened,especiallyfo-cusingonnon-transmissionroutetoeliminatedis-criminationoverpeoplelivingwithHIV/AIDS.Further,educationeffortsalsoshouldbeputonfe-malepopulation,unmarriedpopulationandpoorlyedu-catedpopulation.

简介：现在的纸的主要目的是给Jacobson激进分子，Frattini分系统和一个谎言三倍的系统的c理想的一些性质。有关nilpotent和可解决的谎言三元组系统的Frattini分系统的一些进一步的结果被获得。而且，我们开始为一个谎言三倍的系统开发c理想并且使用他们给一个可解决的谎言三元组系统的一些描述。

简介：AgeopulseseismicsystemwasimplementedtoobtainnewinformationonunderlyingstratabeneaththeYellowRiverDelta.However,owingtotheslippingofseafloorandshallowwater(<25m),freesurface-relatedmultiplesareconflictedwiththeflatprimaries,whichmayinstructtheinterpretersinawrongwayandmakewrongconclusions.Owingtothevariationofmultipleperiods,standardanti-multipletechniquesmaylosetheirpower,suchaspredictivedeconvolution.Surface-relatedmultipleeliminationmethodsareintroducedtoattenuatethemultiplesbasedontheunderlyingwave-equationprinciples.Theresultsjustifiedthemethodonthesingle-channelgeopulseprofile,revealingtherealnatureofthesubsurface.

简介：Theactivationandselectiveconversionofenergy-relatedmoleculesisanimportantresearchareaofenergychemistry.Thedepletionofpetroleumhasstimulatedresearchactivitiesintotheutilizationofnon-petroleumcarbonresourcessuchasnaturalgas(includingconventionaland

简介：AbstractBackground:Homozygous or compound heterozygous mutations in high temperature requirement serine peptidase A1 (HTRA1) gene are responsible for cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL). Recently, increasing evidence has shown that heterozygous HTRA1 mutations are also associated with cerebral small vessel disease (CSVD) with an autosomal dominant pattern of inheritance. This study was aimed to analyze the genetic and clinical characteristics of HTRA1-related autosomal dominant CSVD.Methods:We presented three new Chinese cases of familial CSVD with heterozygous HTRA1 mutations and reviewed all clinical case reports and articles on HTRA1-related autosomal dominant CSVD included in PUBMED by the end of March 1, 2020. CARASIL probands with genetic diagnosis reported to date were also reviewed. The genetic and clinical characteristics of HTRA1-related autosomal dominant CSVD were summarized and analyzed by comparing with CARASIL.Results:Forty-four HTRA1-related autosomal dominant CSVD probands and 22 CARASIL probands were included. Compared with typical CARASIL, HTRA1-related autosomal dominant probands has a higher proportion of vascular risk factors (P < 0.001), a later onset age (P < 0.001), and a relatively slower clinical progression. Alopecia and spondylosis can be observed, but less than those in the typical CARASIL. Thirty-five heterozygous mutations in HTRA1 were reported, most of which were missense mutations. Amino acids located close to amino acids 250-300 were most frequently affected, followed by these located near 150∼200. While amino acids 250∼300 were also the most frequently affected region in CARASIL patients, fewer mutations precede the 200th amino acids were detected, especially in the Kazal-type serine protease domain.Conclusions:HTRA1-related autosomal dominant CSVD is present as a mild phenotype of CARASIL. The trend of regional concentration of mutation sites may be related to the concentration of key sites in these regions which are responsible for pathogenesis of HTRA1-related autosomal dominant CSVD.

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简介：AbstractPsoriasis is a chronic, recurrent, inflammatory skin disease that is often accompanied by obesity. An increasing amount of research has elucidated the pathophysiological link between psoriasis and obesity. Since 2005, interleukin (IL)-17-producing T helper 17 cells and their main effector cytokine IL-17A have been considered to play a critical role in the pathogenesis of psoriasis; the marked effect of biotherapies targeting IL-17A on moderate and severe psoriasis has further established its role in psoriasis. Recent studies have found that obesity induces T helper 17 cells to secrete IL-17A and participate in the pathogenesis of psoriasis. IL-17A may be a crucial element in the association between psoriasis and obesity. This review discusses the association between psoriasis and obesity, with a focus on and the implications regarding the need to treat psoriasis.

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简介：AbstractImmunoglobulin G4-related disease (IgG4-RD) is a newly recognized chronic fibro-inflammatory autoimmune disease, and its recognition has been constantly increasing worldwide over the last few years. A correct and timely recognition, as well as appropriate intervention, is crucial for the treatment of IgG4-RD. For certain subtypes of IgG4-RD, organ-specific criteria are formulated to make the diagnosis more accurate. New biomarkers have emerged in the recent years to aid the disease diagnosis, its prognosis prediction, as well as therapy response monitoring. Although recurrence is very common in IgG4-RD, glucocorticoid is still the first-line treatment for the majority of patients. The factors that affect the likelihood of disease relapse are multifaceted. The selection strategy of various steroid-sparing agents is still being explored. Besides, when patients have special sites involvement leading to severe clinical conditions, surgical operation or interventional therapy should also be considered. An update on classification, diagnosis, and management of IgG4-RD is provided in the current study to fully elucidate the recommended clinical practice of this mysterious disease.

简介：调查apoptosis的表示的目的联系了基因p53；在乳房的管的不正常的增生的bcl-2；在基因表示之间的关系；胸的瘤形成。apoptosis的方法mRNA联系了基因p53；bcl-2被原位杂交在不正常的管的增生的44种情况中检测。p53蛋白质表示被免疫组织化学检测。数据与良性的增生的6个案例的那些相比；胸癌的26个案例。结果p53mRNA的表示在良性的增生是66.7%，40%在不正常的管的增生(55.6%在里面温和，41.7%在媒介，26.1%在里面严重)；19.2%在癌(哪个21.4%是管内的癌；16.7%是侵略的)。p53蛋白质的表示在良性的增生是否定的，24%在不正常的增生(温和11.1%，媒介25%，严重34.8%)，38.5%在癌(管内癌35.7%，侵略管的癌41.7%)。bcl-2的表示在良性的增生是否定的，78.6%在管内癌，83.3%在侵略管的癌。结论损失；p53基因的变化；过多的表示bcl-2mRNA在严重不正常的管的增生被检测。

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简介：让b=(b1，b2……bm)，bieabi(＄N)，1，我，m，bi.0，emi=1bi-b，0，b，1，我们在强壮的类型空间hPB(＄n)上认为围住的海角是ofub。

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简介：Depression/anxietyiscommonlypresentinpacedpatientsandisassociatedwithincreasedcardiovascularmorbidityandmortality.Thehighprevalenceofdepression/anxietyinpacedpatientssupportsastrategyofincreasedawarenessandtreatmentfordepression/anxietyinpacedpatients.Health-relatedqualityoflife(HRQoL)isbeingincreasinglyconsideredasanexpectedout-comeoftherapeuticinterventionsandrehabilitationprogramsinclinicalcardiologyincludingpatientsbeforeandafterpacemaker(PM)implantation.Thismultispecialtyconsensusdocumentreviewstheevidencelinkingdepression/anxietywitharrhythmiaandcardiacpacing;HRQoLandcardiacpacing,atthesametime,providesrecommendationsforhealthcareprovidersforthetreatmentofdepression/anxiety.

简介：Inthisarticle,the2-variablegeneralpolynomialsaretakenasbasewithPeterspolynomialstointroduceafamilyof2-variablePetersmixedtypepolynomials.Thesepolynomialsareframedwithinthecontextofmonomialityprincipleandtheirpropertiesareestablished.Certainsummationformulaeforthesepolynomialsarealsoderived.Examplesofsomemembersbelongingtothisfamilyareconsideredandnumbersrelatedtosomemixedspecialpolynomialsarealsoexplored.

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简介：二维的磁电机水动力学(MHD)方程在这篇文章被考虑。粘滞近似被用来获得古典答案的本地存在和唯一。什么时候粘滞术语消失，集中率，在骚乱的一个主要问题，也被讨论。而且，为我们的古典答案的一个发作标准以磁场被建立。给词调音：MHD方程；古典答案；集中率；发作标准

简介：Undertheimpactofthefinancialcrisis,thegrowthoftheJapaneseeconomybegantoslowdownfromtheendof2007.Tocopewiththecrisis,theJapanesegovernmentputforwardlarge-scaleeconomicstimulusplanswiththeemphasisonimprovingpeople'slivelihood,expandingemployment,propping