简介：在低频率改正测量头相关的转移功能(HRTF)的一个方法被建议。由在低频率从球形的头模型分析HRTF，在400Hz的频率下面，HRTF的大小是将近不变的，阶段为远、近的地两个都是频率的线性功能，这被证明。因此，如果在400Hz上面的HRTF被实验精确地测量，它能由理论模型在低频率改正HRTF。计算和主观实验的结果证明建议方法的可行性。

简介：Anefficientmulti-blockincompressibleviscousflowsolverbasedonsolvingtheReynolds-AveragedNavier-Stokes(RANS)equationsnumericallyhasbeendevelopedthatcanbeappliedtosimulationofavarietyofshipmaneuveringrelatedflowsandcalculationofhydrodynamicforces.Validationandverificationofthesolutionprocedurewerecarriedoutonseveralmodelproblemswithgoodagreementtoexperimentalandnumericalresults.

简介：Objective:Toinvestigatetheexpressionofimmune-relatedmoleculesinglioblastomamultiform(GBM)cells.Methods:Theexpressionofmajorhistocompatibilitycomplex(MHC),β2-microglobulin,Fas,CD80andCD86moleculesonthesurfaceofGBMcellswereevaluatedbyflowcytometry.TheexpressionofTAP-1,TAP-2andTapasinintheGBMcellswereevaluatedbyRT-PCRmethod.Results:MHCclassⅠ,β2microglobulin,TAP-1,TAP-2andtapasinwereexpressedinmostGBMcelllines.ExceptU87,therewasnoMHCclassⅡmoleculeexpressiononanyoftheotherGBMcelllines.FaswasexpressedonalltheGBMcelllinesexamined.Conclusion:ThemechanismbywhichGBMescapesimmunesurveillancemayinvolvedownregulationofexpressionofMHCclassⅠmoleculesandMHCclassⅡmolecules.MHCclassⅠpositiveGBMmaybethesuitabletargetofimmunotherapy.

简介：Globalmitigativeandadaptiveeffortshavenotbeenabletoeffectivelyaddresstheadverseimpactscausedbyclimatechange.Therefore,adirectsolutionisneededtoaddressthesignificantresultinglossanddamage(L&D).DuringtheUnitedNationsFrameworkConventiononClimateChangeheldinDohain2012,theissueofrespondingtoL&Darisingfromclimatechangegainedsuddentractionandbecameoneofthekeyissuesthataffectedtheoutcomeoftheconvention.Inthispaper,astudyonthedefinitionandconnotationsofL&Darisingfromclimatechangewasconducted,togetherwithananalysisofitsrelationshipwithrelatedconcepts,namelyimpacts,vulnerability,andrisks.ThisledtotheproposalofanL&Dconceptualmodelthatismorecomprehensive,withtherecognitionoftheneedtoaddresstheissuethrougheffectivesupplementationofexistingmitigativeandadaptiveefforts.AsystematicelaborationofanL&Dresponsemechanismwasmadebasedonpolitics,law,andthemarket,leadingtoapreliminarypresentationofapossibleformatforanL&Dmechanism.PotentialacademicresearchdirectionsforL&DwerealsoproposedthatcouldserveasreferencesfortheestablishmentofinternationalandnationalL&Dresponsemechanismsandrelatedresearch.

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简介：Ourpreviousreportshaveshownthatlamininglycopeptides(LN-GPs),thetotalglycopeptidespreparedfromlaminin(LN),canpreventtheexperimentallungmetastasisandlivermetastasisofmousecancercells.Inordertoexploretheanti-metastaticmechanismofLN-GPs,westudiedtheeffectsofLN-GPsonmetastasisrelatedbehaviorsofcancercellsinvitro.LN-GPsdidnotaffectcellsurvival.However,LN-GPsinhibitedcellattachmentandspreadingofS180cellsonLN-andMatrigelsubstrateindose-dependentandtime-dependentmanners.Moreover,inhibitionofcellattachmentandspreadingonMatrigelsubstratesweremuchgreateronMatrigelsubstratethanonLNsubstrate.InthegresenceofLN-GPs,S180cellsonLNsubstratechangedfromaflattenedpolygonalshapetoaroundone,themigrationofS180cellsonLNsubstratedecreased,andthenumberofahighlyinvasivehumanpulmonarygiantcarcinomaPGcellsinvadingMatrigelfilterinaBoydenchamberwasreduced.LN-GPsthushavemultipleinhibitoryeffectsoncancermetastasisrelatedbehaviors.

简介：Alaboratory-basedaerobicincubationwasconductedtoinvestigatenitrogen(N)isotopicfractionationrelatedtonitrificationinfiveagriculturalsoilsafterapplicationofammoniumsulfate((NH4)2SO4).Thesoilsampleswerecollectedfromasubtropicalbarrenlandsoilderivedfromgranite(RGB),threesubtropicaluplandsoilsderivedfromgranite(RQU),Quaternaryredearth(RGU),QuaternaryXiashuloess(YQU)andatemperateuplandsoilgeneratedfromalluvialdeposit(FAU).Thefivesoilsvariedinnitrificationpotential,beingintheorderofFAU>YQU>RGU>RQU>RGB.SignificantNisotopicfractionationaccompaniednitrificationofNH+4.δ15NvaluesofNH+4increasedwithenhancednitrificationovertimeinthefouruplandsoilswithNH+4addition,whilethoseofNO-3decreasedconsistentlytotheminimumandthereafterincreased.δ15NvaluesofNH+4showedasignificantlynegativelinearrelationshipwithNH+4-Nconcentration,butapositivelinearrelationshipwithNO-3-Nconcentration.TheapparentisotopicfractionationfactorcalculatedbasedonthelossofNH+4was1.036forRQU,1.022forRGU,1.016forYQU,and1.020forFAU,respectively.Zero-andfirst-orderreactionkineticsseemedtohavetheirlimitationsindescribingthenitrificationprocessaffectedbyNH+4inputinthestudiedsoils.Incontrast,Nkineticisotopefractionationwascloselyrelatedtothenitrifyingactivity,andmightserveasanalternativetoolforestimatingthenitrificationcapacityofagriculturalsoils.

简介：<正>Purpose:Todeterminetheintra-testerreliabilityofclinicalmeasurementsthatassessfivecomponentsrelatedtocorestability:strength.endurance,flexibility,motorcontrol,andfunction.Methods:Participantswere15college-agedmaleswhohadnotsufferedanyorthopedicinjuryinthepastyear.Corestrengthmeasurementsincludedeightisometrictestsandasit-uptest.Thefourcoreendurancetestswerethetrunkflexortest,trunkextensortest,andbilateralsidebridgetests.Flexibilitytestsincludedthesit-and-reachtestandactiverangeofthetrunkandhipjointmotions.Proprioceptionviapassiverepositiontestsofthehipsandasinglelimbbalancetestonanunsteadyplatformwereusedtoevaluatecoremotorcontrol.Functionalmeasurementsconsistedofasquattestandasingleleghoptestfortimeanddistance.Measurementswereperformedduringtwodatacollectionsessionswithaweek’srestbetweenthesessions.Intra-classcorrelationcoefficientswerecalculatedtoestablishreliability.Results:Theoverallintra-raterreliabilityforallcorestabilityrelatedmeasurementsrangedfromlow(ICC=0.35,lefthipreposition)toveryhigh(ICC=0.98,sit-and-reach).Asagroup,thecoreendurancetestswereobservedtobethemostreliable.Conclusion:Therearehighlyreliabletestsineachofthefivegroups.Overall,coreendurancetestsarethemostreliablemeasurements,followedbytheflexibility,strength,neuromuscularcontrol,andfunctionaltests,respectively.

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简介：Deareditor,Itiswithgreatinterestthatwereadthearticle“Relationshipofcalcitoningene-relatedpeptidewithdiseaseprogressionandprognosisofpatientswithseveretraumaticbraininjury”(Chenetal.,2018).Inthisstudy,theauthorsevaluated121patientswhoweredividedintomild/moderatetraumaticbraininjury(TBI)(n=61),severeTBI(n=35)andcontrol(n=25)groups,andmeasuredserumlevelsofcalcitoningene-relatedpeptide(CGRP)andserumendothelin-1(ET-1).TheyfoundthatlowlevelsofCGRPandhighlevelsofET-1wereassociatedwithhighmortalityat6months.IdentificationofmorphologicalabnormalitiesonCTscansisveryimportantforevaluatingpatientswithTBIbecausedifferentdiagnosesaremadebasedondifferentimagingfindings(Maasetal.,2005).

简介：In1980'sdifferentialgeometricmethodsaresuccessfullyusedtostudycurvedexpomentialfamiliesandnormalnonlinearregressionmodels.Thispaperpresentsanewgeometricstructuretostudymultinomialdistributionmodelswhichcontainasetofnonlinearparameters.Basedonthisgeometricstructure,thesuthorsstudyseveralasymptoticpropertiesforsequentialestimation.Thebias,thevarianceandtheinformationlossofthesequentialestimatesaregivenfromgeomentricviewpoint,andalimittheoremconnectedwiththeobservedandexpectedFisherinformationisobtainedintermsofcurvatvremeasures.Theresultsshowthatthesequentialestimationprocedncehassomebetterpropertieswhicharegenerallyimpossiblefornonsequentialestimationprocedures.

简介：由使用DDRT-PCR和EST片断结扎，新奇老鼠胸腺复杂物联系了基因Rwddl被识别。读的框架编码了在N终点包含了一个RWD领域的243氨基酸残余的蛋白质。在胸腺的Rwddl表示在年老、氧化地强调的鼠标被减少。在thymocytes和thymic广泛地被表示被发现上皮的房间。Rwddl的表示水平能影响雄激素受体(AR)的transactivation活动在短暂地transfectedthymic上皮的房间。然而，没有直接相互作用能被荧光回声精力转移检测(烦恼)分析。在结论，Rwddl是胸腺复杂物可以间接地影响AR发信号的相关蛋白质小径。细胞与分子的免疫学。2008；5(4):279-285。

简介：Themultiple-beddedcharacteristicsofthecrustandmultiple-stagenature(geosyncline-platform-diwa)ofthetectoicevolutionarctectonicprcrequisitcsfortheformationandevolutionofthegranitoidsandthcirtungstenmineralizationinJiangxi.ControlledbythemultiPlc-stagetectonicevolution,allthegranitoidsofdiffcrcntgeo1og

简介：AbstractMore evidences show that microRNAs play an important role in the pathogenesis of inflammation and autoimmune diseases including Lichen planus, and are an attractive therapeutic target. MicroRNA family plays an important role in the regulation of gene expression, which involves cell proliferation, apoptosis, growth, differentiation and metabolism, vascularization, immune response and other biological processes. The changes of expression profile and expression level are closely related to the occurrence and development of many diseases, such as tumor, inflammatory disease and autoimmune disease relevant. However, there are few reports on microRNA in the pathogenesis of LP. This review summarizes the research advance of microRNAs (microRNAs -137, microRNAs -125b, microRNAs -138, microRNAs-27b, microRNAs -203) and their downstream proteins in LP.

简介：InstudyingLocalharmonicanalysisonthesphereS",R.S.Strichartzintroducedcertainzonabfunctionsid(x,y))whichsatisfytheequation

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简介：我们在异构的表面上学习流电的水流。在电气化学，生产水流的氧化减小反应被一个非线性的椭圆形的边界价值问题通常建模。边界条件具有有周期性地改变参数的指数的类型。我们由首先一致构造近似这个问题，然后关于一致答案线性化。这近似比以前的近似或直接linearization更加精确。我们为两个建立集中估计二并且三维的大小写并且提供二维的数字实验。

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