简介:Growingevidencehasbeenfoundtosuggestthatearlydevelopmentofthecentralauditorysystemisdependentonacousticstimuli.Peripheraldamagecausedbynoiseexposureandototoxicdrugscaninducefunctionalandanatomicalchangesalongtheauditorypathways.Theinferiorcolliculus(IC)isauniquestructureintheauditorysystemlocatedbetweentheprimaryauditorynucleiofthebrainstemandthethala-mus.DamagetotheICinhibitorycircuitrymayaffectcentralauditoryprocessingandsoundperception.Here,wereviewsomeofthestrikingelectrophysiologicalchangesintheICthatoccurafternoiseexposureandototoxicdrugtreatment.AcommonoccurrencethatemergesintheICafterperipheraldamageishyper-excitabilityofsound-evokedresponse.ThehyperexcitabilityoftheICislikelyrelatedwithreducedinhibi-toryresponsethatrequiresnormalperipheralinputs.Earlyagehearinglosscanresultinalonglastingin-creasedsusceptibilitytoaudiogenicseizurewhichisrelatedtohyperactivityintheICevokedbyloudsounds.OurstudiessuggestthathearinglosscancauseincreasedICneuronresponsivenesswhichmayberelatedtotinnitus,hyperacusis,andaudiogenicseizure.
简介:IntroductionSuddensensorineuralhearingloss(SSNHL)isdefinedasahearinglossofatleast30dBoverthreecontiguousfrequenciesoccurringinlessthan3days[1].VertigoandprofoundhearinglossareconsideredpoorprognosticfactorsinSSNHL[2-4].ThemostcommondiseasesassociatedwithvertigoinSSNHLincludeBPPV,vestibularneu-[3]
简介:Hearinglossandtinnitusareamongthemostcommonconsequencesoflongtermnoiseexposureandre-mainanunder-addressedheathissueinmostdevelopingnationsincludingChina.Therapidindustrializa-tionandlifestylechangesinChinaincreasetheconcernovernoiseexposureandnoiseinducedhearingloss(NIHL).ResearchonNIHLinChinaislimited.ThecurrentpaperreviewsstudiespublishedinEnglishandChineselanguageliteraturesregardingnoiseexposureandNIHLinChina.TheirimplicationontheChi-nesepopulationisdiscussed.ThepossibleutilityofaresearchmodelsuchastheDangerousDecibels?asameanstoincreaseunderstandingofthescopeofNIHLamongtheChinesepopulation,toeducatethegener-alpublicinChina(especiallytheyoung)aboutNIHLanditsprevention,andtostudyeffectsoflanguageandculturalfactorsoninternationalinformationdisseminationandbehavioralinterventionsisproposed.
简介:WedemonstrateamonolithicsinglefrequencyTm-dopedfiberamplifierwithoutputpowerof51.5W.Asinglefrequencyfiberlaserat1.97μmisamplifiedbyacascadedmasteroscillatorpoweramplifier(MOPA)systemwithall-fiberconfiguration.Theoptical-to-opticalconversionefficiencyofthemainfiberamplifieris45%.Noamplifiedspontaneousemission(ASE)orstimulatedBrillouinscattering(SBS)effectisobservedinthefiberamplifier.Theoutputpowercouldbefurtherscaledbylaunchingmorepumppower.
简介:Hearingloss(HL)isthemostcommonsensorydisorder,affectingallagegroups,ethnicities,andgen-ders.AccordingtoWorldHealthOrganization(WHO)estimatesin2005,278millionpeopleworldwidehavemoderatetoprofoundHLinbothears.Resultsofthe2002NationalHealthInterviewSurveyindicatethatnearly31millionofallnon-institutionalizedadults(aged18andover)intheUnitedStateshavetroublehearing.Epidemiologicalstudieshaveestimatedthatapproximately50%ofprofoundHLcanbeattributedtogeneticcauses.Withover60genesimplicatedinnonsyndromichearingloss,itisalsoanextremelyhet-erogeneoustrait.Recentprogressinidentifyinggenesresponsibleforhearinglossenablesotolaryngologistsandotherclinicianstoapplymoleculardiagnosisbygenetictesting.Theadventofthe$1000genomehasthepotentialtorevolutionizetheidentificationofgenesandtheirmutationsunderlyinggeneticdisorders.ThisisespeciallytrueforextremelyheterogeneousMendelianconditionssuchasdeafness,wherethemuta-tion,andindeedthegene,maybeprivate.Therecenttechnologicaladvancesintarget-enrichmentmethodsandnextgenerationsequencingofferauniqueopportunitytobreakthroughthebarriersoflimitationsim-posedbygenearrays.Theseapproachesnowallowforthecompleteanalysisofallknowndeafness-causinggenesandwillresultinanewwaveofdiscoveriesoftheremaininggenesforMendeliandisorders.Thisre-viewfocusesondescribinggenotype-phenotypecorrelationsofthemostfrequentgenesincludingGJB2,whichisresponsibleformorethanhalfofcases,followedbyothercommongenesandondiscussingtheim-pactofgenomicadvancesforcomprehensivegenetictestingandgenediscoveryinhereditaryhearingloss.
简介:Thewaltzingguineapigmaybeagoodmodeltoinvestigateifgeneticfactorcanchangethesensitivityinnoise-inducedhearingloss.Atotalof34waltzigguineapigswerestudiedandwefoundthatthereisnoanysignificantincreasedsensitivitytonoisetraumaiftheage-inducedhearinglosswasconsideredinwaltz-ingguineapig.
简介:WereportthedepositionofNb2O5filmsonunheatedBK-7glasssubstratesusingremoteplasmasputteringsystem.Theremoteplasmageometryallowspseudoseparationofplasmaandtargetbiasparameters,whichofferscompletedepositionratecontrol.Usingappropriateoxygenflowrates,high-densityandlow-lossNb2O5filmsaredepositedwithratesupto0.49nm/s.Lowerdepositionrates(~0.026nm/s)canalsobeobtainedbyworkingatlowtargetcurrentandvoltageandatlowpressure.Nb2O5filmsdepositedatdifferentrateshavetherefractiveindexofabout2.3andtheextinctioncoefficientaslowas6.9×10-5.