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简介：应用时间：2005年8月用户：清华大学所属行业：教育应用系统：清华大学采用了130台基于Intel安腾处理器的HPIntegrityrx2600动能服务器，构建了基于IA-64架构的高性能计算平台，其中的128台rx2600N务器作为计算节点，部署超级计算机集群系统。这个集群系统运行RedHatLirlux操作系统。

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简介：作者在一个居住区域设计了一个生态的暴风雨水系统代替常规地下的隧道让暴风雨水的收集以便减少营养素，沉积排出。这个系统作为解除溢出到附近的溪，一条开的绿沟，一个存储池溏，和naturalsub溪的排水渠道包含自然亚溪。亚溪被设计集成于社区风景，它不仅增加水用法的效率，而且改进在议程21要求了的社区住处区域的美学质量。这研究为一个社区水系统的设计证明了一个开的暴风雨水集合和利用系统的可行性。

简介：Inrecentyears,withthedevelopmentofsocietyinChina,studentshavebeenaffectedbysomenon-mainstreamculturesduringtheirgrowth,causingtheweaknessofmorality,andthegradualdegradationofhonesty.Thosephenomenaimposeseriousimpactsonthegrowthanddevelopmentofchildren.Thestudyinvestigatedthestatusofelementaryschoolstudentcreditthroughquestionnairesurvey.Basedontheresult,thecausesoftheproblemwereanalyzedfromdifferentperspectives,andthena“three-in-one”educationconceptwasproposed.Thecooperationamongfamily,school,andsocietywasstressedtoachievethecomprehensivepromotionofthemoralityandresponsibilityofprimaryschoolstudents.

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简介：Mercury(Hg)isoneofthecommonlyencounteredheavymetals,whichiswidespreadininshoresedimentsofChina.InordertoinvestigatethetoxicityofHgonmarineinvertebrates,westudiedtheeffectsofthedivalentmercuricion(Hg2+)(attwofinalconcentrationsof0.0025and0.0050mgL-1,preparedwithHgCl2)onmetallothionein(MT)content,DNAintegrity(DNAstrandbreaks)andcatalase(CAT)inthegillsandhepatopancreas,antioxidantenzymeactivitiesofsuperoxidedismutase(SOD),catalase(CAT)andglutathioneperoxidase(GPx),inthehemolymph,gillsandhepatopancreasoftheportunidcrabCharybdisjaponicaforanexperimentperiodupto15d.TheresultsindicatedthatMTwassignificantlyinducedafter3d,withapositivecorrelationwithHg2+doseandtimeinthehepatopancreasandanegativecorrelationwithHg2+doseandtimeinthegills.WhileCATinthehemolymphwasnotdetected,itincreasedinthehepatopancreasduringtheentireexperiment;SODandGPxinthethreetissueswerestimulatedafter12h,bothattainedpeakvalueandthenreducedduringtheexperimentalperiod.Meanwhile,DNAstrandbreakswereallinducedsignificantlyafter12h.TheseresultssuggestedthedetoxificationstrategiesagainstHg2+inthreetissuesofC.japonica.

简介：Doubledataratesynchronousdynamicrandomaccessmemory(DDR3)hasbecomeoneofthemostmainstreamapplicationsincurrentserverandcomputersystems.Inordertoquicklysetupasystem-levelsignalintegrity(SI)simulationflowfortheDDR3interface,twosystem-levelSIsimulationmethodologies,whichareboard-levelS-parameterextractioninthefrequency-domainandsystem-levelsimulationassumptionsinthetimedomain,areintroducedinthispaper.BycomparingtheflowofSpeed2000andPowerSI/Hspice,PowerSIischosenfortheprintedcircuitboard(PCB)board-levelS-parameterextraction,whileTektronixoscilloscope(TDS7404)isusedfortheDDR3waveformmeasurement.Thelabmeasurementshowsgoodagreementbetweensimulationandmeasurement.ThestudyshowsthatthecombinationofPowerSIandHspiceisrecommendedforquicksystem-levelDDR3SIsimulation.

简介：Abiomimetichipjointsimulatorthatcanbeusedtoevaluatetheoutcomeofthecementedtotalhipreplacementhasbeendesigned,manufacturedandevaluated.Thesimulatorproducesmotionintheextension/flexionplane,withasockettorotateinternal/externally.Atthesametimeadynamicloadingcycleisapplied.Avalidationtestwasperformedonacementedfemoralstemwithinanovelcompositefemur.Thebonequalityhasastrongeffectonthestemmigrationandontheintegrityoftheinterfaces.Themigrationofthestemisacombinationof3-Dtranslationandrotationofthestem.Underthesameloadingconditions,weakboneallowsmorestemmigrationthanstrongbone.Thereisagreatdecreaseinthestrengthofthestem-cementinterfaceafterthedynamictest,andtheweakbonecompositeexhibitedagreaterreductionininterfacialstrengththanthestrongbonecomposite.Thedecreaseoftheinterfacialstrengthindicatesthattheprimarybondingbetweenthestemandthecementmantlehaddeterioratedandtheintegrityofstem-cementinterfacewasdamaged.Thestudydemonstratesthevalueofusingahipjointsimulatortoinvestigatestemmigrationandinterfaceintegritywithinthecementedhipreplacement,suggestingthatmethodcanbeusedforinvitroevaluationofthebiomaterialsusedinthecementedhipreplacements.

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简介：铜绑定，抛锚膜的、细胞的prion蛋白质(PrPC)有二个组成的劈开地点生产不同N终端和C终端碎片(N1/C1和N2/C2)。用表示也人的PrPC，鼠标PrPC或鼠标PrPC的RK13房间带3F4epitope，这研究在endoproteolytic劈开和一个通常认为的PrPC函数上探索了PrPC主要顺序的影响，地图kinase信号transduction，响应外长的铜与或没有使不安的膜环境。PrPC主要顺序，特别在N1/C1劈开地点附近，看起来在这个地点和细胞外的调整信号的kinase1/2(ERK1/2)phosphorylation影响解朊作用的基础层次，与处理激活增加与基础ERK1/2表明一种反的关系。人的PrPC独自响应铜显示出增加的N1/C1劈开，由特定的p38和JNK/SAPKphosphorylation伴随了。到加扣押胆固醇的抗菌素filipin的铜的联合暴露导致了一只老鼠信号蛋白质phosphorylation的PrPC特定的实质的增加，由N1/C1劈开的增加伴随了。怀有人的N1/C1劈开地点的老鼠PrPC基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在N1/C1劈开地点附近的PrPC主要顺序影响在这个地点处理的endoproteolytic，它显得连接了基础地并且响应铜印射kinase信号transduction。进一步，主要顺序看起来响应外长的刺激在PrPC相关的信号transduction的忠实上授与N1/C1劈开和膜完整的相互的依赖。

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简介：在这篇论文，我们建议一个新关系纲要(R纲要)到XML纲要翻译算法，VQT，它分析价值集的势和用户质问模式并且由在用户询问使用在列和equi加入特征之间的外国关键限制的集的势性质提取含蓄的参考正直。VQT算法罐头把提取暗示参考正直关系信息用于R纲要并且当期末考试结果，创造一个XML纲要。因此，VQT算法阻止R纲要是不正确地折合当翻译代表结果，XML纲要，和它丰富地并且有力地由创造一个XML纲要在R纲要表示所有信息XMLDTD。

简介：临床的试用和动物实验的增加的数字显示出细菌为过敏症预防正在答应工具的那probiotic。这里，我们在过敏促进感受性上分析了三选择乳杆菌紧张的immunomodulatory性质和他们的混合的影响赌1用一只gnotobiotic老鼠建模的v。我们显示出那乳杆菌(L.)rhamnosusLOCK0900，L。rhamnosusLOCK0908和L。caseiLOCK0919经由像使用费的受体被认出2(TLR2)并且核苷酸绑定oligomerization包含域的蛋白质2(NOD2)受体并且刺激骨头在种类依赖者和紧张依赖者礼貌生产cytokines的导出髓的树枝状的房间。殖民无菌(GF)有所有三紧张(Lmix)的混合物的鼠标由加强enterocytes的顶端的junctional建筑群并且恢复延续到终端网的微细丝的结构改进了肠的障碍。与Lmix开拓殖民地于并且敏化1变应原到赌注v的老鼠显著地象一个增加的转变生长因素(TGF)一样在sera和肠的lavages显示出变应原特定的IgE，IgG1和IgG2a和提高的全部的IgA水平的底层-β；与敏化的GF老鼠相比铺平。从开拓殖民地于Lmix的老鼠的Splenocytes和mesenteric淋巴节点房间显示出TGF-β的重要upregulation；在以后在有赌注v的vitro刺激1。我们的结果证明Lmix殖民改进了内脏对赌注v的上皮的障碍和减少的过敏促进感受性1。而且，这些调查结果被传播和能分泌的IgA和规章的cytokineTGF-β的增加的生产伴随；。因此，三乳杆菌紧张的这混合物在人在增加的内脏渗透和过敏症的发作的预防为使用显示出潜力。

简介：AdditivelymanufacturedTi-6Al-4Vlatticestructureshavefoundimportantnicheapplications.However,theyoftenshowinsufficientcompressiveductilityorinsufficientstructuralintegrity.Inthisstudy,abatchof45octahedralTi-6Al-4Vlatticestructureswasmanufacturedinthreedifferentstrutdiameters(0.5,1.0,1.5mm)byselectiveelectronbeammelting(SEBM).Theinfluenceofpost-SEBMannealingonthecompressivedeformationcharacteristicsofthelatticestructurewasinvestigated.Theas-builtTi-6AI-4Vlatticesfragmentedwhenthecompressivestrainreached13%-23%dependingonstrutdiameter.Annealingat950℃(Ptransustemperature:995℃)onlyslightlyimprovedthecompressiveductilityofthelatticestructures.However,annealingat1050℃(p-annealing)fundamentallychangedthecompressivedeformationmodeofthelatticestructures.Theresultantcompressivestress-straincurvewasfeaturedbyalongsmoothplateauandnofactureoccurredevenaftersignificantdensificationofthelatticestructurehadtakenplace(>50%ofcompressivestrain).

简介：从不肥沃的夫妇的28个男搭挡镇定的精液样品被划分成三相等的aliquots并且与三准备了选择媒介，例如PureSperm吗？(Nidacon，Gothenburg，瑞典)，Sil选择加？(Fertipro，Beernem，比利时)并且SpermGrad？(Vitrolife，Gothenburg，瑞典)。在精液参数的吝啬的百分比的差别被重复措施分析估计。精子DNA的关联损坏刻痕结束标记，由终端deoxynucleotidyltransferasedUTP测量了(TUNEL)试金，并且鱼精朊缺乏测量了由与精子参数染色的chromomycinA3(CMA3)，被皮尔森的关联决定。在有所有三媒介的准备以后，精子集中减少了(P<0.05)当有正常形态学的精子的百分比增加了时(P<0.05)。精子活动性，快速的活动性和进步能动集中(PMC)的百分比增加了(P<0.05)为每这些参数，PureSperm准备给了最好的结果(P<0.05)。DNA损坏的百分比在PureSperm和Sil选择正准备减少了(17.9%和31.3%，分别地P<0.05)并且在SpermGrad准备增加了(56.3%，P<0.05)。鱼精朊缺乏也在所有三种媒介减少了，59.3%，47.7%和40.3%为PureSperm，Sil选择加和SpermGrad准备，分别地(P<0.05)。损坏DNA的精子的百分比否定地与精子活动性，快速的活动性和PMC的百分比被相关，但是断然与静态的活动性被相关(P<0.05)。这比较学习和关联分析表明PureSperm准备与最好的活动性和鱼精朊缺乏的最低百分比产出精子。Sil选择正准备与DNA损坏的最低数量产出精子。SpermGrad准备与正常形态学有精子的一个高百分比，而且与DNA损坏有精子的最高的百分比。精子DNA损坏与精子活动性，快速的活动性，静态的活动性和PMC的百分比被相关。

简介：AbstractObjective:To investigate the effects of rosmarinic acid (RA) on the DNA integrity and methylation levels of the H19 differentially methylated region (DMR) of freeze-dried human sperm after 1 week and 6 months of storage at 4℃.Methods:Semen samples from 15 healthy normospermic donors were used in this study. The samples were divided into five groups, including the control group with fresh sperm and four experimental groups with freeze-dried sperm (1-week storage with EGTA buffer solution, Group A; 1-week storage with EGTA buffer solution containing 105 μmol/L RA, Group B; 6-month storage with EGTA buffer solution, Group C; and 6-month storage with EGTA buffer solution containing 105 μmol/L RA, Group D). DNA integrity was evaluated using the sperm chromatin dispersion test. H19 DMR methylation levels were detected by bisulfite sequencing polymerase chain reaction.Results:After 1 week of storage, no differences in sperm DNA integrity were observed among Groups A, B, and controls (P > 0.05). After 6 months of storage, the sperm DNA integrity of Group D did not change significantly compared with that of the control group (P > 0.05), whereas that of Group C decreased significantly (P < 0.05). There were no differences in H19 DMR methylation levels among the five groups (P > 0.05).Conclusions:The DNA integrity of freeze-dried human sperm can be effectively protected by adding RA within 6 months, and the H19 DMR methylation level of human sperm can be maintained for 6 months after freeze-drying.

简介：Thestudyaimstoconfirmtheneuroregenerativeeffectsofbacterialmelanin(BM)oncentralnervoussysteminjuryusingaspecialstainingmethodbasedonthedetectionofCa~(2+)-dependentacidphosphataseactivity.Twenty-fourratswererandomlyassignedtoundergoeitherunilateraldestructionofsensorimotorcortex(groupI;n=12)orunilateralrubrospinaltracttransectionatthecervicallevel(C3–4)(groupⅡ;n=12).Ineachgroup,sixratswererandomlyselectedaftersurgerytoundergointramuscularinjectionofBMsolution(BMsubgroup)andtheremainingsixratswereintramuscularlyinjectedwithsaline(salinesubgroup).NeurologicaltestingconfirmedthatBMacceleratedtherecoveryofmotorfunctioninratsfrombothBMandsalinesubgroups.Twomonthsaftersurgery,Ca~(2+)-dependentacidphosphataseactivitydetectionincombinationwithChilingarian'scalciumadenosidetriphosphatemethodrevealedthatBMstimulatedthesproutingoffibersanddilatedthecapillariesinthebrainandspinalcord.TheseresultssuggestthatBMcanpromotetherecoveryofmotorfunctionofratswithcentralnervoussysteminjury;anddetectionofCa~(2+)-dependentacidphosphataseactivityisafastandeasymethodusedtostudytheregeneration-promotingeffectsofBMontheinjuredcentralnervoussystem.