学科分类
/ 1
2 个结果
  • 简介:Systemictoxicityandinsufficientdrugaccumulationatthetumours让earemainbarriersinchemotherapy.Thermosens让iveliposomes(TSL)combinedwithhighintensityfocusedultrasound(HIFU)hasemergedasapotentialsolutiontoovercomethesebarriersthroughtargeteddrugdeliveryandlocalisedrelease.Owingtothemultiplephysicalandbiochemicalprocessesinvolvedinthiscombinationtherapy,mathematicalmodellingbecomesanindispensabletoolfordetailedanalysisofthetransportprocessesandpredictionoftumourdruguptake.Tothisend,amultiphysicsmodelhasbeendevelopedtosimulatethetransportofchemotherapydrugsdeliveredthroughacombinedHIFU-TSLsystem.Allkeydeliveryprocessesareconsideredinthemodel;theseineludeinterstitialfluidflow,HIFUacoustics,bioheattransfer;drugreleaseandtransport,aswellastumourdruguptake.Thecapabilityofthemodelisdemonstratedthroughitsapplicationtoa2-Dprostatetumourmodelreconstructedfrommagneticresonanceimages.Ourresultsnotonlydemonstratethefeasibilityofthemodeltosimulatethiscombinationtherapy,butalsoconfirmtheadvantageofHIFU-TSLdrugdeliverysystemwithenhancementofdrugaccumulationintumourregionsandreductionofdrugavailabilityinnormaltissue.ThismultiphysicsmodellingframeworkcanserveasausefultooltoassistinthedesignofHIFU-TSLdrugdeliverysystemsandtreatmentregimenforimprovedanticancerefficacy.

  • 标签: Chemotherapy Drug delivery High intensity FOCUSED
  • 简介:Earthquakeengineershavemadealotofeffortstoderiveacomprehensivesetofclosedformexpressionsforperformanceevaluationofframes,whicharealreadypresentedinguidelinessuchasSAC/FEMA.Theseanalyticalexpressionshavebeendevelopedtoestimatetheannualprobabilityofexceedingalimitstate.Intheprocessofsuchseismicassessments,someessentialassumptionsareadoptedtosimplifytheprocess.Oneofthesefundamentalassumptionsdeclaresthatdriftdemandatanyseismicintensitylevelfollowsalognormaldistributionarounditsmedian.Toinvestigatethevalidityofthisassumption,thispaperdescribesacasestudyofthetypesoferrorsthatcouldbeproducedbyusingthesamplemedianasthecentraltendency.BasedontheMaximumLikelihoodEstimationmethodaswellasotherstatisticalevidence,thispaperproposestheuseofthesamplegeometricmeaninsteadofthesamplemedianforthecentraltendency.Further,theresultsofseismicreliabilityevaluationsof4sampleframesarecomparedbasedonutilizingboththegeometricmeanandthesamplemedian.Inthisprocess,bothfirstandsecondorderpowerlawfitsofthehazardcurveareimplementedtocomparetheeffectsofhazardestimationandtheselectionofthecentraltendencyonthefinalresults.Itisobservedintheapplicationexamplethatthesamplegeometricmeancouldleadtomoreaccurateresults.

  • 标签: seismic reliability closed-form expression SAC/FEMA limit