简介：

简介：Theoptimaldurationofdualantiplatelettherapy(DAPT)ofaspirinandaP2Y12receptorblockerafterstentingisstillbeingdebated.ThecurrentrecommendationsforDAPTdurationaresignificantlyfocusedonreducingstentthrombosis;alessfrequenteventwithlaterthanearliergenerationdrugelutingstents(DES).ApersistentoccurrenceoflateandverylatestentthrombosiswithfirstgenerationDESsupportedextendeduseofDAPTbeyondoneyear.However,recentstudieshavedemonstratedthatextendeddurationDAPTisassociatedwithincreasedbleeding;anindependentpredictorforpooroutcomes,includinglong-termmortality.Second-generationDESareassociatedwithlesslateandverylatestentthrombosis.SomerecentstudieshavesupportedashorterdurationofDAPTforsecondgenerationDES.However,thesestudieswereinadequatelypoweredtoassesssignificantdifferencesinstentthrombosis.Furthermore,extendeddurationDAPThasbeenassociatedwithareducedriskofthromboticeventsinnon-culpritvesselsinadditiontostentthrombosisinpatientswithacutecoronarysyndromes(ACS).ThehigherriskofbleedingassociatedwithextendedDAPTtherapyprovidesastrongrationaleforpersonalizedDAPTbasedonpatientriskfactors(e.g.ACSvs.non-ACS),typeofstents,andcost-benefitanalyses.

简介：Objective:Toreportcomplicationsrelatedtoflaparoundimplantsaftercochlearimplantation,possiblecausesofsuchcomplicationsandtreatments.Methodsandmaterial:Weperformedaretrospectiveanalysisofchildreninwhomcomplicationsrelatedtoflaparoundimplantsoccurredafterundergoingcochlearimplantationinourdepartmentfrom2005to2016.Results:Complicationsamong1500cochlearimplantation(CI)recipientsbythesamesurgeonincludedhematoma(n?20)andseromaaroundimplants(n?15),ofwhichmost(n?10)recoveredin2weeksaftereffectivedrainage,utilityofantibioticsandpressuredressing,but5developedflapnecrosisandhadtoundergocontralateralre-implantation.Fourpatientsdevelopedabscessaroundimplants,ofwhom2recoveredafter2weeksofdrainage,gentamicinirrigationanduseofantibiotics,but2patientsendedupwithflapnecrosisandhadtoreceivecontralateralreimplantation.Conclusions:Immediatedrainage,pressuredressingandantibioticscanbeusedtoeffectivelycontrolseromaaroundimplants.Forseromalastingformorethantwoweekswithoutimprovement,surgicaldrainagemaybeneed.

简介：Thecalciumchannelblocker,verapamil,hasbeenshowntoreducescarformationbyinhibitingfibroblastadhesionandproliferationinvitro.Itwasnotclearwhethertopicalapplicationofverapamilaftersurgicalrepairofthenerveinvivocouldinhibittheformationofexcessivescartissue.Inthisstudy,therightsciaticnerveofadultSprague-DawleyratswastransectedandsuturedwithNo.10-0suture.Thestomawaswrappedwithgelfoamsoakedwithverapamilsolutionfor4weeks.Comparedwiththecontrolgroup(stomawrappedwithgelfoamsoakedwithphysiologicalsaline),theverapamilapplicationinhibitedthesecretionofextracellularmatrixfromfibroblastsinvivo,suppressedtypeIandIIIcollagensecretionandincreasedthetotalnumberofaxonsandthenumberofmyelinatedaxons.Thesefindingssuggestthatverapamilcouldreducetheformationofscartissueandpromoteaxongrowthafterperipheralnerverepair.

简介：BackgroundDeepsternawoundinfection(DSWI)aftermediansternotomyforcardiacsurgeryisoneofthemostcomplexandpotentiallylife-threateningcomplications.ItsverydifficulttotreatDSWI,andthereislackofagreementregardingthebesttherapystrategy.Thus,weaimedtosummarizeourexperiencesofsurgicaltreatmentforDSWI,inwhichsatisfactoryclinicalresultswereobtained.MethodsWeretrospectivelyanalyzed17caseswhosufferedfromDSWIaftercardiacsurgeryinourdepartmentfromJanuary2010toJune2015.Therewere8maleand9femalepatientswiththeiraverageageof62.7±9.5years(range42~75years).Allpatientsreceivedreservationofpartofsternumcombinedwithvacuum-assistedsuctiondrainageandbilateralpectoralismajormyocutaneousadvancementflaps.ResultsTheaverageintervalbetweencardiacsurgeryanddiagnosedDSWIwas10.9±6.5days(range5~21days).Timeofvacuum-assistedsuctiondrainagewas11.6±4.8days(range5~15days)andwoundhealingtimewas27.3±7.2days(range23~35days).Allpatientshadanuneventfulpostoperativerecoveryandgoodwoundhealing.Follow-uptimewas33.7±13.3months(range8~74months).Norecurrentinfectionwasobserved.ConclusionsReservationofpartofsternumcombinedwithvacuum-assistedsuctiondrainageandbilateralpectoralismajormyocutaneousadvancementflapsisasimpleandeffectivesurgicalstrategyforthetreatmentofDSWIaftercardiacsurgery.

简介：男富饶上的精索静脉曲张修理的效果仍然保持争论。它将对有用决定了哪个人将从精索静脉曲张修理有益于大多数，并且在那些个人指向修理努力。为精索静脉曲张修理的预示的因素上的文学的详细评论用PubMedNLM数据库被执行。我们发现postvaricocelectomy精液参数的最好的预言者是外科手术前的精液参数。在精液参数的最大的改进与更大的精索静脉曲张在人被发现。当有争吵，更高的睾丸激素，更年轻的年龄和更大的睾丸尺寸时，在一些，研究在精液参数postvaricocelectomy为改进预言。一张诺模图被开发了基于外科手术前的精液参数，精索静脉曲张等级和这个人(www.fertilitytreatmentresults.com)的年龄预言postvaricocelectomy精液参数。有限数据一致地与更高的基线DNA破碎率在人处于DNA破碎率表明最大的改进。关于繁殖结果，更高的基线精子密度一致地为自然怀孕或帮助繁殖技术(艺术)怀孕率预言。另外，精索静脉曲张修理确实似乎为艺术的更侵略的形式减少需要。在结论，我们现在能开始使用象预言跟随varicocelectomy的修理以后的精液质量和富饶潜力的基线精液质量，精索静脉曲张等级和耐心的年龄那样的特定的参数。

简介：Objective:Survivalandtreatmentofpatientswithmicroinvasivebreastcancer(MIBC)remaincontroversial.Inthispaper,weevaluatedwhetheradjuvantchemotherapyisnecessaryforpatientswithMIBCtoidentifyriskfactorsinfluencingitsprognosisanddecidetheindicationforadjuvantchemotherapy.Methods:Inthisretrospectivestudy,108patientswithMIBCwererecruitedaccordingtoseventheditionofthestagingmanualoftheAmericanJointCommitteeonCancer(AJCC).Thesubjectsweredividedintochemotherapyandnon-chemotherapygroups.Wecomparedthe5-yeardisease-freesurvival(DFS)andoverallsurvival(OS)ratesbetweengroups.Furthermore,weanalyzedthefactorsrelatedtoprognosisforpatientswithMIBCusingunivariateandmultivariateanalyses.Wealsoevaluatedtheimpactofadjuvantchemotherapyontheprognosticfactorsbysubgroupanalysisaftermedianfollow-uptimeof33months(13-104months).Results:The5-yearDFSandOSratesforthechemotherapygroupwere93.7%and97.5%,whereasthoseforthenonchemotherapygroupwere89.7%and100%.Resultsindicatethat5-yearDFSwassuperior,butOSwasinferior,intheformergroupcomparedwiththelattergroup.However,nostatisticalsignificancewasobservedinthe5-yearDFS(P=0.223)orOS(P=0.530)rateofthetwogroups.Mostrelevantpoor-prognosticfactorswereKi-67overexpressionandnegativehormonalreceptors.Cumulativesurvivalwas98.2%vs.86.5%betweenlowKi-67(≤20%)andhighKi-67(>20%).ThehazardratioofpatientswithhighKi-67was16.585[95%confidenceinterval(CI),1.969-139.724;P=0.010].Meanwhile,ER(-)/PR(-)patientswithMIBChadcumulativesurvivalof79.3%comparedwith97.5%forER(+)orPR(+)patientswithMIBC.ThehazardratioforER(-)/PR(-)patientswithMIBCwas19.149(95%CI,3.702-99.057;P<0.001).SubgroupanalysisshowedthatchemotherapycouldimprovetheoutcomesofER(-)/PR(-)patients(P=0.014),butnotthosewhooverexpressKi-67(P=0.105).Conclusions:PatientswithMIBCwhooverexpressKi-67and

简介：喷雾器粒子清除的降水是在能改变物理的喷雾器和光性质的空气的一个重要移动过程。这份报纸在在集体集中的situ观察使用的四个雨事件前后在物理的喷雾器和光性质分析变化，数字集中，粒子尺寸分发，散布并且在在Xianghe全面大气的观察的6月和2013年7月的喷雾器的吸收系数在中国驻扎。清除的雨的效果与雨紧张和持续时间，风速度和方向有关的结果表演。在雨事件期间，喷雾器数字集中的时间的变化与在集体集中的变化一致，但是他们的解决尺寸的清除比率是不同的。在雨事件以后，喷雾器团集中的增加与直径以粒子的增加开始了<0.8m[使用空气动力学的粒子sizer(APS)测量]，并且有直径的好粒子<0.1m[使用扫描活动性粒子sizer(SMPS)测量]。降雨在与直径~移开粒子是很有效的0.6m并且比3.5m大。在粒子数字分发的山峰价值的变化(使用SMPS测量)在雨事件在100-120nm以内在粒子上反映强壮的清除效果前后，缩放范围。喷雾器在雨事件前后散布和吸收系数的变化模式是类似的，但是他们的清除比率不同它可能与喷雾器粒子尺寸分发和化学作文有关。

简介：通常，组织缺氧是在松驰的阴茎的一个正常生理的条件，被常规夜的勃起在cavernosal织物的坚持的组织缺氧由于neuropraxia结果在激进的前列腺切除术以后与自发、夜的勃起的正常可勃起的function.1缺乏在男人打断，它导致cavernosal的apoptosis和退化光滑的肌肉纤维。因此，克服组织缺氧被相信在neuropraxia期间起一个关键作用。真空的使用在阴茎康复的可勃起的设备(VED)据说是有效的并且可以阻止阴茎长度的损失。在VED使用以后的肉体的血被增加并且由动脉、静脉的血组成，由颜色Dopplersonography和血气体分析揭示了。类似的现象在否定压力创伤治疗(NPWT)被观察。然而，NPWT比VED，和hypoperfused采用一个更低的否定压力地区，响应邻近创伤边的否定压力增加，被观察。尽管如此，询问考虑理想的低于大气层的压力层次，行动的模式，和VED的治疗学的持续时间仍然保持未答复。而且，一个hypoperfused地区或PO2坡度是否在VED期间出现在阴茎，仍然保持不清楚治疗。在阴茎康复优化一个临床的VED协议，关于VED的机制的进一步的研究，在阴茎的不同部分的特别即时的PO2大小，应该被执行。

简介：在在IOP上调查了triamcinoloneintravitrealtriamcinoloneacetonide的注射的效果的研究的triamcinoloneacetonide.METHODSSystematic文学评论的intravitreal注射以后的intraocular压力(IOP)上的AIMTo报告根据Cochrane合作方法论被进行，报导效果被分析了，Meta-analysis.RESULTSWe发现了IOP跟随inverted-U随着时间的过去以14.81±的平均价值开始的形状模式；1.22而且，学习的土地，变老，绿内障和性作文物质为的以前的历史跨学习在报导IOPchanges.CONCLUSIONOur调查结果是不同的可能在象象反脉管的endothelial生长因素代理人那样的更最近的治疗把它与那些作比较一样决定intravitrealtriamcinoloneacetonide治疗的压力举起风险有用。

简介：AIM:Toassessthevalueofgemstonespectralimaging(GSI)inefficacyevaluationinhepatocellularcancer(HCC)aftertranscatheterarterialchemoembolization(TACE)treatment.METHODS:ThirtypatientswithHCCunderwentGSI,includingnonenhanced,arterial,portalvenousanddelayedphasescans,afterTACEtreatment.ArterialphaseimageswereacquiredwithGSIforreconstructionofvirtualnonenhancedimagesandcoloroverlayimages.Digitalsubtractionangiography(DSA)wasperformedinallthesepatients.Twoblindedandindependentreadersevaluatedthedataintworeadingsessions;standardnonenhanced,arterial,portalvenous,anddelayedphaseimageswerereadinsessionA,andtheoptimalmonochromaticimages,iodine/waterbasedimagesandspectrumfeatureswerereadinsessionB.SensitivityandspecificitywerecalculatedwiththeDSAdataasthereferencestandard.Thesensitivityandspecificitywerecomparedusingtheχ2test.RESULTS:DSArevealed154lesionsin30patients,and100ofthemhadbloodsupply.Overallsensitivityandspecificitywere72%(72/100)and77.8%(42/54)forsessionA,and97%(97/100)and94.4%(51/54)forsessionB,respectively.Thesensitivityandspecificityofthetworeadingsessionsweresignificantlydifferent(χ2=23.04,χ2=7.11,P<0.05).CONCLUSION:ComparedwithconventionalCT,GSIcouldsignificantlyimprovethedetectionofsmallandmultiplelesionswithoutincreasingtheradiationdose.Basedonspectrumfeatures,GSIcouldassesstumorhomogeneityandmoreaccuratelyidentifyresidualtumorsandrecurrentormetastaticlesionsduringefficacyevaluationandfollow-upinHCCafterTACEtreatment.

简介：Background:Thoughthemechanismsofskeletalmuscleregenerationaredeeplyunderstood,thoseinvolvedinmusclecontusion,oneofthemostcommonmuscleinjuriesinsportsmedicineclinics,arenot.Theobjectiveofthisstudyistoexplorethemechanismsinvolvedinmuscleregenerationaftercontusioninjury.Methods:Inthisstudy,atotalof72micewereused.Eightofthemwererandomlychosenforthecontrolgroup,whiletherestweresubjectedtomusclecontusion.Subsequently,theirgastrocnemiusmuscleswereharvestedatdifferenttimepoints.Thechangesinmusclemorphologywereassessedbyhematoxylinandeosin(HE)stain.Inaddition,thegeneexpressionwasanalyzedbyreal-timepolymerasechainreaction.Results:Thedatashowedthattheexpressionofmanygenes,i.e.,specificmarkersofimmunecellsandsatellitecells,regulatoryfactorsformuscleregeneration,cytokines,andchemokines,increasedintheearlystagesofrecovery,especiallyinthefirst3days.Furthermore,therewerestrictrulesintheexpressionofthesegenes.However,almostallthegenesreturnedtonormalat14dayspost-injury.Conclusion:Thesequenceofimmunecellsinvadedaftermusclecontusionwasneutrophils,M1macrophagesandM2macrophages.SomeCC(CCL2,CCL3,andCCL4)andCXC(CXCL10)chemokinesmaybeinvolvedinthechemotaxisoftheseimmunecells.HGFmaybetheprimaryfactortoactivatethesatellitecellsaftermusclecontusion.Moreover,2weeksareneededtorecoverwhenacutecontusionhappensasusedinthisstudy.

简介：AIMTo用光连贯断层摄影术(10月)并且到在奔流外科以后在糖尿病的眼睛估计斑点的量的变化估计开发的发生或有斑点的浮肿变得更坏(我)在糖尿病的眼睛与或没有先存在ME.METHODSIn这未来的、观察研究，经历了奔流外科的60个糖尿病的病人的92只眼睛在外科前被评估并且1，在用10月有斑点的厚度的外科以后的3mo在九有斑点的子字段与10月被测量定义b另外，开发的发生或我变得更坏在糖尿病的眼睛被分析与或没有先存在，ME.RESULTSThe中央子字段平均数厚度增加了21.0µ；m和25.5µ；在1点的m，3mo后续，分别地(P<；0.01)。内部戒指和外部戒指的平均厚度增加了14.2µ；m和9.5µ；在1mo的m，18.2µ；m和12.9µ；在3mo的m。中央包含我在3mo在12只眼睛发展了，包括4与先存在与先存在看中央包含和8只眼睛非中央包含了我。先存在的糖尿病的有斑点的浮肿(DME)显著地与中央包含被联系我开发(P<；0.001).CONCLUSIONA尽管增加是温和的，统计上重要的增加能在中央子字段以及perifoveal和parafoveal部门被检测。并且有在奔流外科以前的外科手术前的DME的眼睛在为开发中央包含的更高的风险我。

简介：Theadipocytokine,apelin-13,isanabundantlyexpressedpeptideinthenervoussystem.Apelin-13protectsthebrainagainstischemia/reperfusioninjuryandattenuatestraumaticbraininjurybysuppressingautophagy.However,secondaryapelin-13effectsontraumaticbraininjury-inducedneuralcelldeathandblood-brainbarrierintegrityarestillnotclear.Here,wefoundthatapelin-13significantlydecreasescerebralwatercontent,mitigatesblood-brainbarrierdestruction,reducesaquaporin-4expression,diminishescaspase-3andBaxexpressioninthecerebralcortexandhippocampus,andreducesapoptosis.Theseresultsshowthatapelin-13attenuatessecondaryinjuryaftertraumaticbraininjuryandexertsaneuroprotectiveeffect.

简介：AIMTo在在为复杂网膜的detachment.METHODSWe经历retinectomy的病人的硅酮油(ROSO)的移动执行了为复杂网膜的分开在retinectomy以后经历了ROSO的病人的回顾的盒子笔记评论以后，评估功能的结果。有不到6mo的病人列在后面在上面并且周期性的网膜的分开追随者ROSO是excluded.RESULTSThirty--六个病人被包括。吝啬的最好改正的视觉尖酸(BCVA)pre-ROSO是1.13logMAR(SD0.5)。吝啬的BCVA3mo追随者ROSO是1.16logMAR(SD0.53)，6mo追随者ROSO1.13(SD0.63)，和跟随ROSO1.18(SD0.69)的12mo。在在ROSO以后的12mo，BCVA在38.9%病人改善了，在25%仍然保持未改变，并且尽管在在在3点的ROSO以后的BCVA没有统计重要差别，在36.1%败坏了，6并且12mo(P=0.93)。retinectomy的尺寸从15°；到270°；(SD53)并且没影响.CONCLUSIONThere是的视觉结果(P=0.11)在在pre-和柱子之间的BCVA的没有统计上重要的差别--为复杂网膜的分开的ROSO后面的retinectomy。在与retinectomy的尺寸有关的视觉结果没有统计差别。

简介：在JanuaryFebruary2008期间，严重的冰暴风雨在南部的中国引起了重要损坏到森林，创造华盖差距和变化土壤营养素可获得性和酶活动。为了理解在差距尺寸，在土壤环境的变化和这些变化穿上的效果之间的关系，玷污过程，我们在在在Cunninghamialanceolata的森林差距的化学、生物的性质在北广东省承受的土壤上调查了差距尺寸的效果，南部的中国。十自然地创造的差距，五大(80100m2)并且五小(3040m2),在C的看台被选择。lanceolata。大差距在010厘米土壤与小差距和邻近的盖住华盖的阴谋相比在土壤潮湿，有机物，N和P在轻传播比率和空气和土壤温度和衰落显示出重要增加。在在大、小的差距和盖住华盖的阴谋之间发现的有机物和滋养的层次的差别可能与处于环境条件的变化有关。在大差距沥滤的这显示的快速的崽分解和增加的营养素。而且，因为衰落，过氧化氢酶，酸磷酸酶和urease活动的底层在他们的土壤富饶发生在大差距。大森林差距可以有差的富饶的一个区域，减少在C以内的土壤营养素可获得性和酶活动。lanceolata看台。

简介：由利用兔子模型，以前的研究发现了好证据显示那导致输精管切除术的spermatogenic损坏是调停压力的：当堵塞的繁殖的道是不能的提供睾丸生产的另外的精子时，损坏发生。然而，与更通常使用的老鼠模型一起的更多的研究显示出损坏是否并且为什么发生的争论结果。在这研究，12只成熟男Sprague-Dawley老鼠受到单方的输精管切除术：两倍结扎(没有切断)管，deferens经由一个小腹股沟的切口暴露了；在操作，睾丸，epididymides，vasadeferentia(juxta-epididymal片断)，和精子granulomas以后的37天(在输精管切除术地点)被移开获得嵌入树脂的节和morphometric研究与光执行了的methacrylate显微镜学。有spermatids和spermatocytes的显著spermatogenic损坏在43%生精的小管侧面在生精的上皮弄空在vasectomized方面上在12个睾丸中的5个被表明，并且损坏与更小或不在的精子granulomas被联系；在有实质上正常的精子发生的另外的7个睾丸，有增加(在111%平均)在小管腔的体积，与包含更多的精子的更大的granulomas或granulomas联系了。有全面增加(在66%)在在12个睾丸的网睾丸的厚度；epididymis或管deferens没显示出扩张。它因此似乎输精管切除术在老鼠导致的spermatogenic损坏也是调停压力的，并且处于损坏的那个变化主要取决于精子granuloma的手术后的发展。

简介：

简介：Alargeproportionofmutantswithalteredpigmentfeatureshavebeenobtainedviaexposuretoheavy-ionbeams,atechniquethatisefficientfortraitimprovementinthebreedingofplantsandalgae.However,littleisknownaboutthechangesofthephotosyntheticresponseofmicroalgaeafterexposure.Inourgroup,sixprogeniesofScenedesmusquadricaudadeficientinchlorophyllawereisolatedaftercarbon-ionexposurethatwereprovidedbytheheavyionresearchfacilityinLanzhou(HIRFL),China.Twoprogenieswerepickedupbecausetheirphotosyntheticefficiencyandthephotoprotectionabilityweremarkedlydifferentfromthewildtype.

简介：Inthisstudy,theresidualstrainofathinconductivemetalwireonapolymersubstrateafterelectricalfailureismeasuredwithSEMmoir′e.Focusedionbeam(FIB)millingisappliedtofabricatemicronmoir′egratingsonthesurfacesofconstantanwiresandtherandomphaseshiftingtechniqueisusedtoprocessmoir′efringes.Thevirtualstrainmethodisbrieflyintroducedandusedtocalculatetherealstrainofspecimens.Inordertostudytheinfluenceofadefectontheelectricalfailureoftheconstantanwire,experimentswereconductedontwospecimens,onewithacrack,whiletheotheronewithoutanycrack.Bycomparingtheresults,wefoundthatthedefectmakesthecriticalbeamcurrentofelectricalfailuredecrease.Inaddition,thespecimensweresubjectedtocompressionafterelectricalfailure,inagreementwiththeobservedcrackclosureofthespecimen.Thesuccessfulresultsdemonstratethatthemoir′emethodiseffectivetocharacterizethefull-fielddeformationofconstantanwiresonthepolymermembrane,andhasagoodpotentialforfurtherapplicationtothedeformationmeasurementofthinfilms.