简介:Marineecologicalnicheshaverecentlybeendescribedas"particularlypromising"sourcesforsearchofnewantimicrobialstocombatantibiotic-resistantstrainsofpathogenicmicroorganisms.Marineorganismsareexcellentsourcesformanyindustrialproducts,buttheyarepartlyexplored.Over30000compoundshavebeenisolatedfrommarinesources.Bacteria,fungi,andcyanobacteriaobtainedfromvariousmarinesourcessecretseveralindustriallyusefulbioactivecompounds,possessingantibacterial,antifungal,andantimycobacterialactivities.Sustainablecultivationmethodsforpromisingmarineorganismsandbiotechnologicalprocessesforselectedcompoundscanbedeveloped,alongwiththeestablishmentofbiosensorsformonitoringthetargetcompounds.Thesemisyntheticmodificationsofmarine-basedbioactivecompoundsproducetheirnewderivatives,structuralanalogsandmimeticsthatcouldserveasnovelleadcompoundsagainstresistantpathogens.Thepresentreviewfocusesonpromisingantimicrobialcompoundsisolatedfrommarinemicrobesfrom1991-2013.
简介:Europeisnowfacingadifficulttime,withasluggisheconomy,refugeecrisis,frequentterroristattacks,plusBrexit.Whatalotofpeopleviewedasarichandsafeparadisehasnowturnedouttobesomethingelse.Althoughthedebtcrisisiscurbedatthemoment,economicproblemsremainandwillgiverisetomorecrises.Therefore,Europe’scrisesarefarfromover.Inasense,theyarejustbeginning.
简介:Thisstudyisthefirsttoreporttheradiocarbonages,mineralogical,morphological,geochemicalandstableisotopecompositionsofcalcretesfromNeogenesedimentsaroundlakesEymirandMoganintheG?lba??BasinofCentralAnatolia.MorphologicallydifferentformsofcalcretesintheG?lba??Basinincludepowdery,nodular,fractureinfill,laminarandhardpantypes.Calciteisthedominantmineralofcalcretecompositions;thediagnosticfeaturesofdessicationcracks,randomfractures,MnOliningsanddensespariticinfillingsareobserved.Chemicalanalysesshowaridconditionswithmeanannualprecipitationof<50mm.δ13Ccompositionsofthecalcretesrangefrom-6.77‰to-9.32‰PDB,typicalformostpedogeniccalcretes,reflectingthedevelopmentunderseasonallyaridclimatesandC3-dominatedvegetationcover.δ18Ovaluesarebetween-5.57‰and-7.80‰PDB,indicatingtheformationfrommeteoricwaterinavadosezoneenvironment.TheresultssuggestthattheMiddlePleistocenewasariderandwarmer,favouringtheformationofpalygorskiteinassociationwiththedifferentformsofcalcreteoccurrences,whereastheLatePleistocenewasdryerandcooler,supportingthedevelopmentofcalcretes.