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简介：BACKGROUND:Theuseofacupuncturehasreceivedrecognitiontoeffectivelytreatcerebralpalsy.Moreover,musictherapycanbeusedtomodifytreatmentofcerebralpalsy.OBJECTIVE:Tostudytheeffectsofcombinedtreatmentusingacupunctureandmusictherapyongrossmotorfunctionmeasure(GMFM)ofchildrenwithcerebralpalsy,comparedwithacupuncturetreatmentalone.DESIGN,TIMEANDSETTING:Randomized,controlled,clinicalstudy.TheexperimentwasconductedinShenzhenHospitalofTraditionalChineseMedicinebetweenJanuary2007andSeptember2007.PARTICIPANTS:AllchildrenwithcerebralpalsyinthetrialwerefromtheoutpatientdepartmentofShenzhenHospitalofTraditionalChineseMedicine.Thechildrenwererandomlydividedintotwogroups:30childreninGroupBreceivedacupunctureandmusictherapy,while30childreninGroupAreceivedonlyacupuncturetherapy.METHODS:SubjectsinGroupsAandBreceivedacupuncturebasedonsyndromedifferentiation.Themainacupointswerenecessaryforallparticipants.Atfirst,flashneedlingwasappliedtotheacupoints.Fortheremainingacupoints,thetechniqueoftransverseneedlingwasappliedtotheheadacupoints,andperpendicularneedlingwasusedfortheotherpoints.Theinsertedneedlesweretwirledandthenmaintainedfor30minutes.Theneedlewastwirledforonesecondeveryother10minutes,withoutreinforcing-reducingtechniques.Thetherapywasperformedeveryotherday.Thetrialconsistedofthreeperiodseach,andlastedfor84days.SubjectsinGroupBreceivedmusictherapy.Theylistenedtomusicthattheypreferredwhileacupuncturewasbeingperformed.Followingacupuncture,theywereallowedtoperformmusicalactivities,suchaspercussion,singing,anddancing.Themusictherapywasscheduledforonehour,includinglisteningtomusicfor30minutesandmusicactivitiesfor30minutes.MAINOUTCOMEMEASURES:ThecomprehensivefunctionalevaluationscaleofcerebralpalsyandtheGMFMwereappliedtotestsymptomsbeforeand

简介：BACKGROUND:Ithasbeenreportedthatperoxisomeproliferator-activatedreceptorγ(PPARγ)ishighlyexpressedinlungcancer,coloncancer,andgastriccancer,aswellasothertumors.OBJECTIVE:TostudyexpressionofPPARγinpituitaryadenomasandanalyzetheroleofPPARγinhormonaltypingofpituitaryadenomas.DESIGN,TIMEANDSETTING:Semi-quantitativeimmunohistochemistryofpathologicalspecimens.TheexperimentwasconductedattheDepartmentofNeurosurgery,WuxiSecondHospitalAffiliatedtoNanjingMedicalUniversitybetweenJanuary2002andMay2005.MATERIALS:Surgicalresectionsamplesofpituitaryadenomasfrom38cases(18maleand20female)wereanalyzed.Eightcasesweredeterminedtobeinvasivepituitaryadenomasand30caseswerenon-invasivepituitaryadenomas.Hormonalclassificationofthetypesofpituitaryadenomasrevealedsomatotrophicadenomasinsixcases,corticotrophicadenomainfivecases,prolactinomasin13cases,multi-hormonesecretingadenomasinsixcases,andeightcasesofadenomawithoutalteredendocrinefunction.Fiveautopsyspecimenswerecollectedduringthesameperiodfrompatientsofmatchingagethatdiedfromunrelateddiseasesandwereincludedasnormalanteriorpituitarycontrols.METHODS:Cellcountsforpositiveimmunohistochemicalsignalswererecordedfromhistopathologicalsections.Thepercentageofpositivecellswasreportedasasemi-quantitativeanalysis.MAINOUTCOMEMEASURES:TherateofPPARγpositivecellsindifferenttypesofadenomawasbasedonhormonallevelsandinvasivenessofpituitarytumorcells.RESULTS:AlltumorbiopsiesweredeterminedtoexpressPPARγTherateofPPARγ-positivecellsrangedbetween8%-65%inthepituitaryadenomas.Accordingtohormonaltype,PPARγexpressiondidnotvarybetweenthegroups.Inaddition,therewasnosignificantdifferenceinPPARγexpressionbetweenthenon-invasiveandinvasivepituitaryadenomas.CONCLUSIONS:HumanpituitaryadenomasexpressPPARγ,andthisexpressionisunrelatedto