简介：Inthelastseveralyears,therateofinnovationincardiacimagingtechniqueshasacceleratedsignificantly.Advanceshavebeenseeninall4majormodalities;echocardiography,nuclear(positronemissiontomography(PET)andsinglephotonemissioncomputedtomography(SPECT),cardiacmagneticresonanceimaging(CMR),andcomputedtomographicangiography(CTA).ThisissueofCardiovascularInnovationsandApplicationswillhighlightmanyoftheseadvances.

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简介：Elevatedheartrateisamajorriskfactorforcardiovasculardiseases.Theinhibitoroffunnycurrent(I(f)),ahyperpolarization-activatedcyclicnucleotide-gatedchannelcurrent,ivabradineisanewagentselectivelyreducingheartratedevoidofothercardiovasculareffects,whichhascomeintothemarketinEuropeformorethan3years.Ithasbeenapprovedthatpureheartratereductionbyivabradinecanimprovemyocardialischemia,endothelialfunctionandmyocardialcontractilefunction.Long-termadministrationwillnotincreaseall-causemortality.Itstherapeuticvalueinstablecoronaryarterydiseasehasbeenverifiedinclinicalpractice,whileinotherfieldsofcardiovasculardiseasesstillneedsmoreevidence-basedmedicalresearch.Thisarticleisareviewaboutitsrecentresearchadvancesinexperimentalandclinicalstudies.

简介：AlthoughanassociationbetweenthegroupAbetahemolyticstreptococcusandrheumaticfeverhasbeenrecognizedformorethanhalfacentury,manyimportantissuesaboutthisrelationshipremainincompletelydefined.Theinitiatingpharyngealthroatinfectionand