学科分类
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1 个结果
  • 简介:Administrationofautoantigencanbeofvalueforpreventionofautoimmunediabetesandithasbeenspeculatedthatthecontrolpointofdendriticcells(DC)fortheinductionofperipheraltoler-ancemaybehighlyrelevant.WeexaminedthepropertiesofDCassociatedwithimmunesuppressioninNODmicebyinsulininjectionsubcutaneouslyandtheirabilitytosuppressdiabetestransferbydiabeto-geniceffectorcellsinsecondaryNOD-SCIDrecipients.OurdatashowedthatthesurfaceexpressionsofMHCⅡandCD86onNOD-derivedDCwereincreasedafterinsulintreatmentcomparedwiththoseonPBScontrolledmice.ThedendriticcellswithamaturephenotypeandincreasedMLRstimulationadop-tivelytransferredimmunetolerogeniceffectsonsecondaryNOD-SCIDmice,whichwereassociatedwithsignificantlygreaterIL-10,TGF-betaproductionandCD4~+CD25~+TdifferentiationfromsplenocytescomparedwithNOD-SCIDcontrolrecipients.Moreover,treatmentwithDCremarkablydecreasedtheincidenceofdiabetesinsecondaryrecipients.TheseresultssuggestthatasubtypeofDCgeneratedbyinsulinsubcutaneoustreatedNODmiceconferspotentialprotectionagainstdiabetesthroughpolarizingtheimmuneresponsetowardsaTh2regulatorypathway.

  • 标签: 自身抗原 免疫力 糖尿病 枝状细胞