Autoantigen administration confers diabetes-preventive properties to NOD mice derived dendritic cells-中国期刊网

摘要 Administrationofautoantigencanbeofvalueforpreventionofautoimmunediabetesandithasbeenspeculatedthatthecontrolpointofdendriticcells(DC)fortheinductionofperipheraltoler-ancemaybehighlyrelevant.WeexaminedthepropertiesofDCassociatedwithimmunesuppressioninNODmicebyinsulininjectionsubcutaneouslyandtheirabilitytosuppressdiabetestransferbydiabeto-geniceffectorcellsinsecondaryNOD-SCIDrecipients.OurdatashowedthatthesurfaceexpressionsofMHCⅡandCD86onNOD-derivedDCwereincreasedafterinsulintreatmentcomparedwiththoseonPBScontrolledmice.ThedendriticcellswithamaturephenotypeandincreasedMLRstimulationadop-tivelytransferredimmunetolerogeniceffectsonsecondaryNOD-SCIDmice,whichwereassociatedwithsignificantlygreaterIL-10,TGF-betaproductionandCD4~+CD25~+TdifferentiationfromsplenocytescomparedwithNOD-SCIDcontrolrecipients.Moreover,treatmentwithDCremarkablydecreasedtheincidenceofdiabetesinsecondaryrecipients.TheseresultssuggestthatasubtypeofDCgeneratedbyinsulinsubcutaneoustreatedNODmiceconferspotentialprotectionagainstdiabetesthroughpolarizingtheimmuneresponsetowardsaTh2regulatorypathway.

1Cong Wu;Yi Zhang;Yingnling Jiang;Quanxing Wang;Yao Long;Chunmei Wang;Xuetao Cao;Guoyou Chen. Apoptotic cell administration enhances pancreatic islet engraftment by induction of regulatory T cells and tolerogenic dendritic cells.免疫学,2013-05.
2鲁峰;高建华. Adipose tissues differentiated by adipose-derived stem cells harvested from transgenic mice.临床医学,2006-06.
3Shi Jie Wang Yu Qin Duan Yan Zhi Xu Su Xin Zhang. Biological characteristics of monocyte-derived dendritic cells from peripheral blood of patients with oral carcinoma.口腔医学,2008-06.
4Zhao Wen Chuan Wang Dong Hui Sun Hui Li Xiu Bao Ren. Immune response induced by dendritic cells transfected with adenoid cystic carcinoma cells total RNA inhibits the growth of implanted tumor in vivo in nude mice.口腔医学,2008-12.
5Fengguang Gao;Xin Hui;Xianghuo He;Dafang Wan;Jianren Gu. Dysfunction of Murine Dendritic Cells Induced by Incubation with Tumor Cells.免疫学,2008-02.
6Guangyang Liu;Lihua Wang;Tianxiang Pang;Delin Zhu;Yi Xu;Hanyu Wang;Xiuli Cong;Yongjun Liu. Umbilical cord-derived mesenchymal stem cells regulate thymic epithelial cell development and function in Foxn 1^-/- mice.免疫学,2014-03.
7Xuemei Fu. The immunogenicity of cells derived from induced pluripotent stem cells.免疫学,2014-01.
8Huifen Zhu;Wenhong Qiu;Ping Lei;Wei Zhou;Xue Wen;Fengrong He;Li Li;Hong Dai;Guanxin Shen;Feili Gong. IL-10 Gene Modified Dendritic Cells Inhibit T Helper Type 1-Mediated Alloimmune Responses and Promote Immunological Tolerance in Diabetes.免疫学,2008-01.
9Yang Fang,Zhang Wan-Lin,Chen Shu-Qiang,Sun Hui-Jun,Lu Jie,Xiao Xi-Feng,Wang Xiao-Hong. Differentiation of Human Adipose-Derived Stem Cells into Endometrial Epithelial Cells.医药卫生,2020-10.
10韩岩梅;曹雪涛. Cross-talk between Natural Killer Cells and Dendritic Cells in Innate and Adaptive Immunity.基础医学,2004-03.

Autoantigen administration confers diabetes-preventive properties to NOD mice derived dendritic cells

来源期刊

相关推荐

同分类资源更多

相关关键词

Autoantigen administration confers diabetes-preventive properties to NOD mice derived dendritic cells

来源期刊

相关推荐

同分类资源 更多

相关关键词

同分类资源更多