On the Organizational Dynamics of the Genetic Code

(整期优先)网络出版时间:2011-01-11
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Theorganizationofthecanonicalgeneticcodeneedstobethoroughlyilluminated.Herewereorderthefournucleotides-adenine,thymine,guanineandcytosine-accordingtotheiremergenceinevolution,andapplytheorganizationalrulestodevisinganalgebraicrepresentationforthecanonicalgeneticcode.Underaframeworkofthedevisedcode,wequantifycodonandaminoacidusagesfromalargecollectionof917prokaryoticgenomesequences,andassociatetheusageswithitsintrinsicstructureandclassificationschemesaswellasaminoacidphysicochemicalproperties.Ourresultsshowthatthealgebraicrepresentationofthecodeisstructurallyequivalenttoacontent-centricorganizationofthecodeandthatcodonandaminoacidusagesunderdifferentclassificationschemeswerecorrelatedcloselywithGCcontent,implyingasetofrulesgoverningcompositiondynamicsacrossawidevarietyofprokaryoticgenomesequences.Theseresultsalsoindicatethatcodonsandaminoacidsarenotrandomlyallocatedinthecode,wherethesix-folddegeneratecodonsandtheiraminoacidshaveimportantbalancingrolesforerrorminimization.Therefore,thecontent-centriccodeisofgreatusefulnessindecipheringitshithertounknownregularitiesaswellasthedynamicsofnucleotide,codon,andaminoacidcompositions.