Objective:Thisstudyaimstoexploretheclinicopathologicfeaturesof112patientswithmantlecelllymphoma(MCL).Methods:Datafrom112MCLcaseswerecollected,andimmunohistochemicalassaywasconducted.Fluorescenceinsituhybridization(FISH)detectedabreakintheCCND1gene.Thet-testwasusedinthestatisticalanalysis.Results:Alltumorcellsinthe112casesexpressedBcell-relatedantigen,including1blastoidsubtypeand1polymorphicsubtype.Amongallcases,106expressedCD5and104expressedcyclinD1.AbreakintheCCND1genewasnotfoundin3caseswithCD5-MCL.IgH/CCND1polyploidwasobservedin2classiccases.Conclusion:MCLisatypeofspecialimmunophenotypicB-celllymphoma.Theprognosesofblastoidandpolymorphicsubtypesarepoor.Specialsubtypesshouldbeclassifiedduringdiagnosis.
