TheallelicdistributionofEcoRIandBamHIfragmentsofrasfamilygenesbetweenthehumanprimarygastriccancertissuesandthecorrespondingadjacentnormaltissuesdidnotshowanydifferences.ThreegenotypesofBamHIrestrictionfragmentslengthpolymorphismofc-H-raswererevealed.NosignificantdifferencesintheRFLPswereobservedbetweennormalinpidualsandgastriccancerpatients.Fourprotooncogenes,c-H-ras,N-ras,c-mycandc-fos,werefoundtobetranscriptionallyactiveinthegastriccancertissuesinsomecasesexamined.Thecomparisonoftheexpressionoftheseoncogenesbetweenthemalignanttissuesandthecorrespondingnormaltissuesshoweddifferentialpatterns.Theexpressionofc-H-rasatcellularlevelwasdetectedwithinsituhybridization.Theenhancedexpressionofc-H-rasinthegastriccancercellswasdemonstrated,butthedegreeoftheexpessionamongthecancercellswasshowntobeheterogeneous.Inaddition,theenhancedexpressionofc-H-raswasseeninthei
