简介:SmallRNA(sRNA)-mediatedpost-transcriptionalregulationdiffersfromprotein-mediatedregulation.Throughbasepairing,sRNAcanregulatethetargetmRNAinacatalyticorstoichiometricmanner.Sometheoreticalmodelswerebuiltforcomparisonoftheprotein-mediatedandsRNA-mediatedmodesinthesteady-statebehaviorsandnoiseproperties.ManyexperimentsdemonstratedthatasinglesRNAcanregulateseveralmRNAs,whichcausescrosstalkbetweenthetargets.Here,wefocusonsomemodelsinwhichtwotargetmRNAsaresilencedbythesamesRNAtodiscusstheircrosstalkfeatures.Additionally,thesequence-functionrelationshipofsRNAanditsroleinthekineticprocessofbase-pairinghavebeenhighlightedinmodelbuilding.
简介:摘要目的探讨乳头Paget’s病的临床特点、诊断及治疗方法,提高对乳头Paget’s病的诊治水平。方法回顾性分析我院2011年8月至2014年8月间收治的12例乳头Paget’s病患者的临床资料结果单纯湿疹样改变者2例,单纯乳腺肿块者3例,乳头湿疹样改变伴乳腺肿块者7例。最终病理证实乳腺浸润性导管癌伴乳头Paget’s病者8例,占所有病例的66.7%;导管内癌伴乳头Paget’s病者3例,占所有病例的25%;导管内癌局部微浸润伴乳头Paget’s病者1例,占所有病例的8.3%。结论乳头paget’s多伴有乳腺深部肿块,伴肿块的乳头paget’s病出现浸润性乳腺癌的可能性较大。预后较单纯浸润性乳腺癌差,需更为积极的综合治疗。
简介:AmericansociologistMasondefinesthewomen'ssocialstatusasaproductofsocialorganizationsystem,makingthemostefficientuseofwomeninthesocialdevelopmentisthemostimportantpartofthewomen'ssocialstatus.Womenalsohavefullyautonomyinafamilyorsocialdecisionevenenjoyspecialprivileges.
简介:Thispaperpresentsamodifiedhalf-sine-squaredloadmodelofthejumpingimpulsesforasingleperson.Themodelisbasedonadatabaseof22,921experimentallymeasuredsinglejumpingloadcyclesfrom100testsubjects.Threedimensionalmotioncapturetechnologyinconjunctionwithforceplateswasemployedintheexperimenttorecordjumpingloads.Thevariationrangeandprobabilitydistributionofthecontrollingparametersfortheloadmodelsuchastheimpactfactor,jumpingfrequencyandcontactratio,arediscussedusingtheexperimentaldata.Correlationrelationshipsbetweenthethreeparametersareinvestigated.Thecontactratioandjumpingfrequencyareidentifiedasindependentmodelparameters,andanempiricalfrequency-dependentfunctionisderivedfortheimpactfactor.Thefeasibilityoftheproposedloadmodelisestablishedbycomparingthesimulatedloadcurveswithmeasuredones,andbycomparingtheaccelerationresponsesofasingle-degree-of-freedomsystemtothesimulatedandmeasuredjumpingloads.Theresultsshowthatarealisticindividualjumpingloadcanbegeneratedbytheproposedmethod.Thiscanthenbeusedtoassessthedynamicresponseofassemblystructures.
简介:InChina,thedevelopmentofhumanrightsisaninherentpartofgoodgovernance,asreflectedinthefollowing:Firstly,peopleareabletoparticipateinsocialandpublicadministrationthroughexercisingtheir"democraticrights"undertheconstitution.Secondly,citizens’fundamentalhumanrightsandothercivilrightsareprotectedbylaw.Thirdly,people’srightstoknowandtoexpressareexpanding.Fourthly,theChinesegovernmentisresponsivetopeople’sdemands,readytoaccepttheirsupervision,andisdoingitsbesttoimprovetheirlivingstandard.Tomodernizegovernance,Chinamustadheretohumanrightsprinciplesbyguaranteeingpeople’srightstoparticipation,toinformationandtosupervision,andbyprotectingthefundamentalrightsofthedisadvantaged.
简介:Byusingsequentiallylowercompletespaces(see[Zhu,J.,Wei,L.,Zhu,C.C.:Caristitypecoincidencepointtheoremintopologicalspaces.J.AppliedMath.,2013,ID902692(2013)]),wegiveanewversionofvectorialEkeland’svariationalprinciple.Inthenewversion,theobjectivefunctionisdefinedonasequentiallylowercompletespaceandtakingvaluesinaquasi-orderedlocallyconvexspace,andtheperturbationconsistsofaweaklycountablycompactsetandanon-negativefunctionpwhichonlyneedstosatisfyp(x,y)=0iffx=y.Here,thefunctionpneednotsatisfythesubadditivity.FromthenewEkeland’sprinciple,wededuceavectorialCaristi’sfixedpointtheoremandavectorialTakahashi’snon-convexminimizationtheorem.Moreover,weshowthattheabovethreetheoremsareequivalenttoeachother.Byconsideringsomeparticularcases,weobtainanumberofcorollaries,whichincludesomeinterestingversionsoffixedpointtheorem.
简介:Thelegalconfirmationprocessofwomen’shumanrightshasbeenundergoinggreatdifficultiesbothintheUnitedNationsandamongnations.TheFourthWorldConferenceonWomenplaysaroleinpromotingthelegalprotectionofwomen’shumanrights.Currently,theprotectionofwomen’shumanrightshasundoubtedlybecometheconsensusofbothinternationalanddomesticlaw.Internationalconventionsonhumanrightshavebecomeanimportantlaunchingareaforpromotinginternationallawonwomen’shumanrights,owingtoitslegalbindingforceandsupervisingmechanismestablishedunderit.Domesticlawhasalsobecomethefirstlineofdefenseforprotectingwomen’shumanrights.However,itneedstobepointedoutthat,forinternationalconventionsonhumanrightsanddomesticlegislation,thecognitionandacceptanceofsocialgenderconceptionhasnotonlypromotedchangesonforms,but,moreimportantly,onrevolutionatsubstantiallevel.
简介:Theindustrialsectorisusuallythelargesteconomysectorforcarbonemissionsinmanycountries,whichmadeitthesectorwithgreatestpotentialforcarbonreductionalthoughtheprocessdurationmightbeverylong.StudyingthepotentialofindustrialemissionreductionhasgreatsignificanceinestimatingthecarbonemissionpeakofChinaontheonehand,andadjustingitsstrategyininternationalclimatechangenegotiations.Byemployingtheeconomicaccountingmethod,thisarticleestimatestheemissionreductionpotentialofChina’sIndustrialsectorfortheperiodof2010-2050.Itrevealsthat,taking2030astheyearwhentheemissionreachesthepeak,thetotalreductioncanbe8.38billiontons(bts)fortheperiodof2010-2030,with3.12btsfromstructuralreductionwhile5.26btsfromintensityreduction.Afterwards,reductionwillcontinuewithatotalamountof6.59btsfortheperiodof2030-2050,wherethestructuralreductionaccountsfor2.47bts,andintensityreduction4.115bts.Ifbothindustrialandenergyconsumptionstructuresareimprovedduringtheaboveperiod,thereductionpotentialcanbeevengreater,e.g.theemissionpeakcanarrivefiveyearsearlier(intheyearof2025)andthepeakvaluecandeclinebyabout8%ascomparedtotheoriginalestimation.Reviewingthetrajectoryofemissionchangesindevelopedcountriesindicatesthattheindustrysectorcancontributetotheoverallreductiontargetsthroughthedualwheelsofstructuralreductionandintensityreduction,evenbeyondtheemissionpeak.Thisarticleconcludeswiththefollowingpolicysuggestions.(1)OurestimationontheemissionpeakoftheindustrialsectorsuggeststhatChinashouldavoidanycommitmentearlierthan2030onthetimelineoftheoverallemissionpeak;(2)thegreatpotentialofindustrialemissionreductioncanimprovethesituationofChinainclimatechangenegotiation,wheretheintensityreductioncanserveasanimportantpolicyoption.(3)Reductionpotentialcanbefurtherenhancedthroughtechnologyadv