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简介：AbstractPancreatic neuroendocrine neoplasms (pNENs) are highly heterogeneous, and the management of pNENs patients can be intractable. To address this challenge, an expert committee was established on behalf of the Chinese Pancreatic Surgery Association, which consisted of surgical oncologists, gastroenterologists, medical oncologists, endocrinologists, radiologists, pathologists, and nuclear medicine specialists. By reviewing the important issues regarding the diagnosis and treatment of pNENs, the committee concluded evidence-based statements and recommendations in this article, in order to further improve the management of pNENs patients in China.

简介：AbstractUrticaria is a common dermatological condition that is characterized by wheals and pruritus. Certain types of urticaria can be resistant to treatment, and recurrence is common. These guidelines supplement and improve upon the previous version (published in 2014) of the Guidelines for the Diagnosis and Treatment of Urticaria in China, and incorporate recent research advances in urticaria. These guidelines are suitable for both Chinese adults and children of Han nationality with urticaria. These guidelines update and broaden the definition, pathogenesis, classification, diagnosis, and treatment of urticaria, and serve as a scientific and authoritative reference for the diagnosis and management of urticaria.

简介：Thispaperevaluatestheutilizationoffreeradicalchemiluminescenceimagingandtomographicreconstructiontechniquestoassessadvancedinformationonreactingflows.Twodifferentlaboratoryflowconfigurationswereanalyzed,includingunvonfinednon-premizedjetflamemeasurementstoevaluateflamefuel/airmixingpatternsattheburner-portofatypicalglass-furnaceburner.Thesecondcasecharacterizedthereactionzoneofpremixedflameswithingasturbinecombustionchambers,basedonalaboratoryscalemodelofaleanprevaporizedpremixed(LPP)combustionchamber.Theanalysisshowsthatadvancedimagingdiagnosiscanprovidenewinformationonthecharacterizationofflamemixingandreactingphenomena.TheutilizationoflocalC2andCHchemiluminescencecanassessusefulinformationonthequalityofthecombustionprocess,whichcanbeusedtoimprovethedesignofpracticalcombustors.

简介：Anovelrobustfaultdiagnosisscheme,whichpossessesfaultestimatecapabilityaswellasfaultdiagnosisproperty,isproposed.Theschemeisdevelopedbasedonasuitablecombinationoftheadaptivemultiplemodel(AMM)andunknowninputobserver(UIO).ThemainideaoftheproposedschemestemsfromthefactthattheactuatorLock-in-Placefaultisunknown(whenandwheretheactuatorgetslockedareunknown),andmultiplemodelsareusedtodescribedifferentfaultscenarios,thenabankofunknowninputobserversaredesignedtoimplementthedisturbancede-coupling.AccordingtoLyapunovtheory,proofoftherobustnessofthenewlydevelopedschemeinthepresenceoffaultsanddisturbancesisderived.Numericalsimulationresultsonanaircraftexampleshowsatisfactoryperformanceoftheproposedalgorithm.

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简介：AIM:Toinvestigatethediagnosticaccuracyofthemeanplateletvolumeandplateletdistributionwidthinacuteappendicitis.METHODS:Thisretrospective,case-controlledstudycompared295patientswithacuteappendicitis(Group?Ⅰ),100patientswithotherintra-abdominalinfections(GroupⅡ),and100healthyindividuals(GroupⅢ)betweenJanuary2012andJanuary2013.Theage,gender,andwhitebloodcellcount,neutrophilpercentage,meanplateletvolume,andplateletdistributionwidthvaluesfrombloodsampleswerecomparedamongthegroups.StatisticalanalyseswereperformedusingSPSSforWindows21.0software.Inaddition,thesensitivity,specificity,positiveandnegativepredictivevaluesandlikelihoodratios,anddiagnosticaccuracywerecalculated.RESULTS:Themeanagesofpatientswere29.9±12.0yearsforGroup?Ⅰ,31.5±14.0yearsforGroupⅡ,and30.4±13.0yearsforGroupⅢ.Demographicfeaturessuchasageandgenderwerenotsignificantlydifferentamongthegroups.Whitebloodcellcount,neutrophilpercentageandplateletdistributionwidthweresignificantlyhigherinGroup?Ⅰ?comparedtogroupsⅡandⅢ(P<0.05).Diagnostically,thesensitivity,specificityanddiagnosticaccuracywere73.1%,94.0%,and78%forwhitebloodcellcount,70.0%,96.0%,and76.0%forneutrophilpercentage,29.5%,49.0%,and34.0%formeanplateletvolume,and97.1%,93.0%,and96.0%forplateletdistributionwidth,respectively.ThehighestdiagnosticaccuracydetectedwasforplateletdistributionwidthbetweenGroup?Ⅰ?andGroupⅢ(P<0.01).CONCLUSION:Plateletdistributionwidthanalysiscanbeusedfordiagnosisofacuteappendicitiswithoutrequiringadditionaltests,thusreducingthecostandlossoftime.

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简介：ItisprovedinthispaperthatNWPsystematicforecasterrorsinthezonalmeancirculationareduetothedifferenceinwesterlyaccelerationprocessduringtheforecastingperiodbetweenmodelandrealatmospheres.Thoseforcingfactorswhichevokethezonalmeanwindvariationcanbesplitintovariouslineartermsaccordingtothenon-accelerationtheoreminaprimitiveequationsystem,Byapplyingthistech-niquetothediagnosisoftheforecastproduetsoftheT42L9modelinJanuary1992andinJuly1992,itisindicatedthatthemodelhastheabilitytoforecastthezonalmeanwindtoareasonableextent,buttherearestillsomeerrorsinseveralplaces,especiallyintheuppertroposphereandlowerstrato-sphereinthemid-latituderegionaswellasnearthesurface.Theresultsofanalysisbyemployingthisschemerevealthereasonresponsibleforthesystematicforecasterrorsofthezonalmeanwindinthemodelandthepossiblewayofimprovingit.Itisalsoshownthatnon-accelerationtheoremcanbeusedasanefficienttooltodiagnosethephysicalprocessesofNWPmodels.

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简介：AbstractA pancreatic cystic neoplasm (PCN) is a rare pancreatic disease. Malignant PCNs are usually identified incidentally while evaluating other lesions. However, PCNs are being identified more frequently owing to the increased use of abdominal imaging. Malignant PCNs have complicated and diverse biological behaviors, including various malignant risk factors, diverse molecular features, natural history, and complex pathological classifications. Although many diagnostic methods, such as cross-sectional imaging and endoscopic evaluation, have been developed, malignant PCNs are still difficult to differentiate from benign tumors. On searching for related articles in the recent decade, we found that some molecular biomarkers such as carcinoembryonic antigen could be useful for discriminating between malignant tumors and benign tumors. However, cytopathologic evaluation is the most useful method for differentiating between benign and malignant lesions. Although cytopathologic evaluation has a specificity of 100% for identifying malignancies, its accuracy is often hampered by the low cellularity of PCN cells in the cystic fluid. Herein, we review the progress in the use of cellular and molecular markers for the accurate identification of PCNs.

简介：AbstractPemphigus vulgaris (PV) is a life-threatening autoimmune bullous disease that causes blisters and erosions on the skin and mucous membranes to standardize the diagnosis and treatment of PV, Chinese experts in this field were invited to make recommendations which are presented in this article. Pemphigus vulgaris can be divided into cutaneous mucous type, cutaneous type and mucous mucous dominant type according to the different clinical manifestations. The pathological manifestations of PV are acantholysis above the basal layer. The diagnosis of PV and the assessment of the severity of the disease are made in accordance with the clinical manifestations, histopathological features, immunofluorescence assay results, and detection of pathogenic serum antibodies. The first-line treatment of PV comprises systemic glucocorticoids. Early combination with immunosuppressive agents or rituximab is recommended for moderate and severe PV. Intravenous immunoglobulin administration is recommended for patients being treated with rituximab. Plasma exchange and stem cell transplantation can be performed if necessary. During the course of therapy, the disease activity should be closely monitored, and actions should be taken to prevent adverse reactions.

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简介：Developingtheradiographicimagesfromtwotothree-dimensional,finiteelementanalysis(FEA)technologycansetupthemodel,predictingdiagnosis,treatmentdesign,aswellassurgicalplan.FEAprovidesanaccuratethree-dimensionalfiniteelementbiomechanicalstudyinosteonecrosisoffemoralhead(ONFH).Thepapersinthelatest5yearsrelatedtofemoralheadosteonecrosisandfiniteelementanalysisapplicationareconcentratedon.Wesummarizethelatestresearchprogressandproblems,includingtheappliedresearchcarriedoutinthefemoralheadosteonecrosisclinicalcases,innovationalskills,soastopointoutthedirectionoffutureresearchinFEA.

简介：ObjectivesToreportauthors'experiencesinthediagnosisandtreatmentsofcongenitalfirstbranchialfistula(congenitalauriculocervicalfistula).MaterialsandMethodsTwelvecasesofcongenitalfirstbranchialfistulawerereviewed.Ofthese,8underwentfistulectomywithfacialnervedissectionandpartialparotidectomyand4underwentsimplefistulectomy.ResultsTheinneropenings(upperopening)offistulaelayinthefollowingsites:inferioposteriorwallatthejunctionofcartilaginousandbonysegmentsoftheauricularcanalandinferiorwallofcartilaginousauricularcanal.Theouteropenings(loweropening)layalongtheanteriorborderofuppersternocleidomastoidmuscle,atthemastoidtipandposteriortothemandibularangle.Completefistulaeresectionwasachievedinallbutonecase.Elevencaseswerefollowedfor5yearwithnorecurrence.Recurrenceoccurredin1case6monthsaftertheprimarysurgeryandrevisionsurgerywasperformed.ConclusionsPre-operativeradiographyforthelocationandcourseofthefistulaiscrucialforsuccessfulfistularesection,especiallyincaseswithpastinfections.Facialnervedissectionshouldbedoneroutinelyfordeeplylocatedfistulae.

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简介：AbstractIrritable bowel syndrome (IBS) is a common functional gastrointestinal disease worldwide. Current guidelines of IBS are mostly based on the western populations and expected to vary in different communities. China has a large population and a vast literature is available on IBS. Due to linguistic variations in the literature, the studies are not widely known and their conclusions thus remain largely obscured to the western medical literature. In this article, we reviewed the published literatures on the investigations of IBS epidemiology, diagnosis, and management in the Chinese population and emphasized the different findings gleaned from the western publications. The detailed literature review will benefit understanding of and promote future study on IBS.

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