简介:SHANDONG,abigindustrialandagriculturalprovincewithalargepopulation,hassummarizedaclearurbanizationconcept.TheprovinceunveiledonSeptember3,2014itsdevelopmentplan(2014-2030)foranewruralcommunityandnewruralarea.Asaresult,some14,ooovillages,ofapopulationofaround14million.
简介:Activationofthephosphoinositide3kinase(PI3K)/Akt/mammaliantargetofrapamycin(mTOR)pathwayiscommoninbreastcancer.Thereispreclinicaldatatosupportinhibitionofthepathway,andphaseⅠtoⅢtrialsinvolvinginhibitorsofthepathwayhavebeenorarebeingconductedinsolidtumorsandbreastcancer.Everolimus,anmTORinhibitor,iscurrentlyapprovedforthetreatmentofhormonereceptor(HR)-positive,humanepidermalgrowthfactorreceptor2(HER2)-negativebreastcancer.Inthisreview,wesummarisetheefficacyandtoxicityfindingsfromtherandomisedclinicaltrials,withsimplifiedguidelinesonthemanagementofpotentialadverseeffects.Educationofhealthcareprofessionalsandpatientsiscriticalforsafetyandcompliance.WhilethereissomeclinicalevidenceofactivityofmTORinhibitioninHR-positiveandHER2-positivebreastcancers,thebenefitsmaybemorepronouncedinselectedsubsetsratherthanintheoverallpopulation.FurtherdevelopmentofpredictivebiomarkerswillbeusefulintheselectionofpatientswhowillbenefitfrominhibitionofthePI3K/Akt/mTOR(PAM)pathway.
简介:INMay2013,YunnanChihongZincandGermaniumCo.,Ltd.(Chi-hongZn&Ge)bought51percentofthesharesoftwoBolivianminingcompaniesandundertookamonth-longevaluationofthemines'localenviron-ments.LaRazonnewspaper,whichhasthebiggestcirculationinBolivia,reportedChihong'sacquisitionwiththeheadline"Chinaassessestheenviron-mentalimpactoftheirinvestments,"claimingthattheminingprojectswerethefirsttopassthetestinBolivia.