简介:AIM:Totestthehypothesisthatamblyopicneuroretinamayhaveanalteredthicknesswhencomparedtothenormal.·METHODS:Twenty-fiveamblyopic,youngpatientsbetweentheagesof7and11yearsoldwerestudied.Theinterestedneuroretinaareasaredefinedinto10sub-regionsaccordingtosuperior-inferior,nasal-temoral,andperi-paraaxis,whichcrossthefovelastructure.Thethicknessesoften,definedmacularregionswereseparatelymeasuredbyopticalcoherencetomography(OCT)andanalyzedbyt-test.·RESULTS:Theaveragethicknessofneuroretinaintheexactfoveolaoftheamblyopiceyesislargerthanthatofnormaleyes(P<0.05),buttheothernineregionshavenosignificantdifference.Interestingly,inboththenormalandamblyopiceyes,thetemporalarealooksthinnerthanotherquadrants(P<0.05).·CONCLUSION:Thicknessalterationmaybeassociatedwithamblyopicdisordersinyoungpatients.Studyingalargervolumeofsubjectsofsimilarageisrequiredtoconfirmthisobservation.
简介:【摘要】目的:探究家庭医生的健康教育对社区高血压患者的血压影响。方法:选取2023年1月-2023年12月我社区医院收治的社区高血压患者98例作为本次研究对象,按奇偶分组法分为对照组(49例),观察组(49例),对照组给予常规教育干预,观察组给予家庭医生干预,对比两组血压控制效果。结果:干预前,两组患者血压值对比(P>0.05)无统计学意义;干预后,观察组患者血压低于对照组(P<0.05),差异存在统计学意义。结论:针对社区高血压患者,采用常规教育干预效果不理想,而家庭医生干预是临床优质路径,可降低舒张压和收缩压水平并且保持稳定,有利于患者血压控制。
简介:AIM:ToinvestigatetheinterferingeffectofY-27632,aROCK-Iselectiveinhibitor,onthesignaltransductionpathwayoftransforminggrowthfactor-β1(TGF-β1)inocularTenoncapsulefibroblasts(OTFS)invitro.METHODS:AfterOTFSfrompassages4to6invitrowereinducedbyTGF-β1andthentreatedbyY-27632,thechangesoftheOTFScellcycleswereanalyzedviaflowcytometry,andtheproteinsexpressionoftheα-smoothmuscularactin(α-SMA),connectivetissuegrowthfactor(CTGF),collagenIwerecalculatedbyWesternblot.AfterOTFStreatedbythedifferentconcentrationsofY-27632,theexpressionlevelsoftheα-SMA,CTGFandcollagenImRNAwereassayedbyRT-PCR.RESULTS:Y-27632hadnomarkedlyeffectontheOTFScellcycles.AftertreatedbyTGF-β1,OTFSinG1periodsignificantlyincreased.ThecellcyclesdistributionbybothTGF-β1andY-27632hadnoremarkabledifferencefromthatincontrolgroup.Y-27632significantlyinhibitedtheproteinsexpressionsofbothα-SMAandCTGF,whiletosomeextentinhibitedthatofcollagenI.TGF-β1significantlypromotedtheproteinsexpressionsofα-SMA,CTGFandcollagenI.AfterOTFStreatedbybothTGF-β1andY-27632,ofα-SMA,theproteinexpressionwassimilarwiththatincontrolgroup(P=0.066>0.05),buttheproteinexpressionofCTGForcollagenI,respectively,wassignificantlydifferentfromthatincontrolgroup(P=0.000<0.01).Thedifferencesofexpressionsoftheα-SMA,CTGFandcollagenImRNAin30,150,750μmol/LY-27632groupwerestatisticallysignificant,comparedwiththoseincontrolgroup,respectively(α-SMA,P=0.002,0.000,0.000;CTGF,P=0.014,0.002,0.001;collagenI,P=0.003,0.002,0.000).CONCLUSION:BlockingtheRho/ROCKsignalingpathwaybyusingofY-27632couldinhibitthecellularproliferationandtheexpressionofbothCTGFandα-SMAwhateverOTFSinducedbyTGF-β1ornot.Y-27632suppressedtheexpressionofcollagenImRNAwithoutinduction.
简介:摘要目的研究并分析心电图诊断右室梗死的临床价值及相关诊断标准。方法此次研究的对象是选取该院于2014年6月—2016年5月收治49例确诊的右室梗死患者,将其临床资料进行回顾性分析,所有患者均接受心电图检查,对所有患者的基本资料进行回顾性分析,同时对患者的心电图检查结果与临床确诊结果进行对比分析。结果心电图诊断为右冠闭塞性心肌梗死13例,临床确诊14例,诊断符合率为92.86%;心电图诊断为回旋支闭塞性心肌梗死8例,临床确诊9例,诊断符合率为88.89%;心电图诊断为急性下壁合并右室梗死24例,临床确诊26例,诊断符合率为92.31%;总符合率为91.84%。结论在右室梗死的临床诊断上,心电图的诊断效果较为显著,临床诊断符合率高,具有应用和推广价值。若为特殊情况,则可采用心电图联合右胸导联实施临床检测,提高临床诊断有效率和准确性。
简介:摘要目的分析甲状腺功能检测对自然流产患者的影响。方法抽取2011年1月至2012年1月在我院妇科接受自然流产患者作为研究组,随机抽取正常生育患者作为对照组,两组患者年龄、身体状况无其它差异。运用罗氏化学发光仪e411对患者甲状腺功能进行检测,包含游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)、甲状腺球蛋白(TG)、甲状腺过氧化物酶抗体(A-TPO)、抗甲状腺球蛋白抗体(A-TG)等甲状腺功能实行检测,患者自愿配合检测。结果对照组和研究组患者检测FT4、TSH数据对比具有统计学意义,分析表明发生自然流产患者和患者有无进行人工流产生产数据有关。结论研究组与对照组两组数据分析,为降低自然流产和防止患者自然流产提供有效数据。