简介：目的探讨几种改良鼻腔泪囊吻合术的手术方式。方法收集2007年2月-2010年6月28例29眼慢性泪囊炎,行改良鼻腔泪囊吻合术的病例,分别行单纯吻合瓣悬吊术,吻合口填充明胶海绵加前瓣悬吊术,吻合口填充医用吸血海绵或导尿管术。结果26例27眼治愈或好转,有效率93.1%。结论本文几种改良鼻腔泪囊吻合术疗效确定,可针对不同病情采取不同的改良鼻腔泪囊吻合术。

简介：眼反应分析仪（reichertocularresponseanalyzer，ORA）是一种新型非接触喷气式眼压计。它利用一种动态双向压平过程测量眼压，不仅使测得的眼压值真实可靠，免受中央角膜厚度和硬度的影响，而且可得到反应角膜生物力学特性的新指标：角膜滞后量和角膜阻力因素。其操作简单，能自动显示眼压读数及角膜生物力学特性。该仪器精确度高，可重复性好，非接触特性，因此可广泛用于临床监测眼压，尤其适用于已行准分子激光角膜屈光手术后的患者，但仍需进一步明确其对青光眼诊断和治疗的指导作用。

简介：目的：探讨分析超声乳化手术前作视觉电生理检查对白内障预后的临床价值。方法：选取2009-01/2010-10在我院行白内障超声乳化手术治疗的白内障患者,针对直接和间接眼底镜下眼底窥不清253例,术前作视觉电生理检查了解视网膜和视神经情况以判断预后。结果：该253例患者中有47例经视觉电生理检查提示预后较差,其中接受白内障手术37例,有35例术后视功能恢复也相应较差（术后视力提高≤2行）,2例术后视功能恢复情况相对较好（术后视力提高〉2行）,另10例放弃手术;206例经视觉电生理检查提示预后较好,其中201例接受白内障手术,有199例术后视功能恢复也相应较好（术后视力提高〉2行）,2例术后视功能恢复情况相对较差（术后视力提高≤2行）,5例因有全身其他疾病不能手术。结论：白内障术前作视觉电生理检查了解视网膜及视神经情况,对于判断手术预后有良好的可预测性。

简介：目的：分析《标准对数视力表》与《低视力视力表》对远用视力检查的临床意义及临床价值。方法：随机抽取本院验光部验光患者59例（118眼）,每位患者分别进行两种视力表的远用视力检查,然后记录裸眼视力以及矫正视力检查结果,再进行配对设计资料检验。结果：裸眼视力检查t=2.9944,矫正视力检查t=3.5564,P〈0.05,两种视力表无论是裸眼视力还是矫正视力在统计学上均有显著性差异。结论：两种视力表的视力检查结果有所差异,裸眼视力相差19.953′视角,矫正视力相差15.849′视角,且低视力专用视力表的均值均小于标准对数视力表。

简介：目的探讨小梁切除联合丝裂霉素C治疗青光眼的临床疗效.方法应用小梁切除术联合丝裂霉素C治疗32例（45眼）各型青光眼,术中一次性使用0.2mg/ml丝裂霉素C,术后随访6-24月,观察其临床疗效及其并发症.结果术后1月检查,33眼（73.33％）术后视力有不同程度的提高；术后1周测眼压,平均11.20--2.15mmHg,术后6月测眼压,平均16.86mm±3.81mmHg,均较术前有统计学差异；末次随访时,41眼（91.1％）形成弥散扁平的功能性滤过泡；总手术成功41眼（91.1％）.术后主要并发症为：浅前房2眼,前房积血1眼,角膜水肿3眼.讨论小梁切除联合丝裂霉素C治疗青光眼,可有效地减少青光眼术后滤过道瘢痕的形成,充分降低眼压.该方法不需要特殊设备,并发症少,手术效果好,是一种安全、有效的治疗青光眼方法.

简介：眼内病毒感染多由疱疹病毒家族导致。在免疫功能正常者中,以病毒性前葡萄膜炎与急性视网膜坏死综合征较为常见。对免疫功能低下者,有巨细胞病毒视网膜炎及进行性外层视网膜坏死,两者均发生在获得性免疫缺陷综合征（AIDS）后期。其他非AIDS患者,如白血病、器官移植、恶性肿瘤或自身免疫性疾病,因长期使用免疫抑制剂亦可发生巨细胞病毒视网膜炎。本文结合文献分别对上述眼内病毒感染性疾病进行叙述。

简介：患者，女，31岁，孕29wk。以“体检时发现人免疫缺陷病毒（HIV）抗体（＋）4mo，WBC下降1wk”入院。患者在孕10wk查体时发现HIV抗体（＋），除自觉倦怠外，无其他不适。2mo前查：CD420个／L，予HAART（叠氮胸苷＋拉米呋定＋耐伟抗平）治疗。入院查体：WBC0．8×10^9／L，Hb100g／L。

简介：AIM:Toexploretheeffectofsaturatedhydrogensalineonbluelight-inducedretinaldamageinrats.·METHODS:Theretinaldamageofratswasinducedbybluelightexposurefor6hoursandexamined8hours,16hoursand24hoursaftertheexposure.OnehundredfemaleSprague-Dawleyratswererandomlydividedintofourgroups.Group1included30ratsreceivedlightexposurewithoutanyothertreatment.Group2included30ratsreceivedlightexposurewithintraperitonealinjectionofnormalsaline.Group3included30ratsreceivedlightexposurewithintraperitonealinjectionofsaturatedhydrogensaline.AndGroup4includedtheother10ratswhichdidnotreceiveanytreatment.Theamountofintraperitonealinjectionofsaturatedhydrogensalineandnormalsalinewascalculatedintheratioof1ml/100gofratweight.SpecimenswerecollectedandprocessedbyH-Estaining,ultrastructureobservation,biochemicalmeasurement.Morphologicalchangeswereobservedbylightmicroscopeandtransmissionelectronmicroscope(TEM)andtheretinalouternuclearlayer(ONL)thicknesswasmeasuredbyIPP6.0,whilethemalondialdehyde(MDA)wasmeasuredbycolorimetricdeterminationat532nm.·RESULTS:AlthoughthestructureofretinainGroup1andGroup2wasinjuredheavily,theinjuryinGroup3wasmild.ThedifferencesbetweenGroup1andGroup2werenotsignificant.ComparedwiththeratsinGroup1andGroup2,theonesinGroup3hadmoreclearlydemarcatedretinastructureandmoreorderedcellsbylightmicroscopeandTEMobservation.TheONLthicknesses(400times)offourgroupsateachtimepointexceptbetweenGroup1andGroup2weresignificantlydifferent(P<0.05).ThethicknessesoftheONLinGroup1atthreetimepointswere30.41±4.04μm,26.11±2.82μmand20.63±1.06μm,inGroup2were31.62±4.54μm,25.08±3.63μmand19.07±3.86μm,inGroup3were29.75±3.62μm,28.83±1.97μmand27.61±1.83μm.InGroup4themeanofthethicknesswas37.35±1.37μm.Astimewentby,thedamageg

简介：AIM:Toestimatetheprevalenceandriskfactorsforvitreousfloatersinthegeneralpopulation.·METHODS:Anelectronicsurveywasadministeredthroughasmartphoneappaskingvariousdemographicandhealthquestions,includingwhetherusersexperiencefloatersintheirfieldofvision.Multivariatelogisticregressionanalysiswasusedtodetermineriskfactors.·RESULTS:Atotalof603individualscompletedthesurvey,with76%reportingthattheyseefloaters,and33%reportingthatfloaterscausednoticeableimpairmentinvision.Myopeswere3.5timesmorelikely(P=0.0004),andhyperopes4.4timesmorelikely(P=0.0069)toreportmoderatetoseverefloaterscomparedtothosewithnormalvision.Floaterprevalencewasnotsignificantlyaffectedbyrespondentage,race,gender,andeyecolor.·CONCLUSION:Vitreousfloaterswerefoundtobeaverycommonphenomenoninthisnon-clinicalgeneralpopulationsample,andmorelikelytobeimpairinginmyopesandhyperopes.

简介：AIM:ToexploretheinhibitoryeffectofasustainedcyclosporinA(CsA)deliverymicrosphere(CsA-MS)onposteriorcapsularopacification(PCO)inrabbiteyesaftercataractextraction.·METHODS:TwentyNewZealandwhiterabbitsacceptedcataractextractionplusintraocularlensimplantationandtheirlefteyeswereintraoperativelyinjectedCsA-MSpreparedusingpolymerpolylactioglycolicacid(PLGA)asacarrierandtheirrighteyeswereinjectedwithemptyMS.Thechangesincornea,anteriorchamberreaction,intraocularpressure,PCOandCsAconcentrationinaqueoushumorwereexaminedpostoperativelyandalltheeyeswereenucleated3monthsaftersurgeryforhistopathologicalandmorphologicalexaminationwithlightmicroscopyandelectronmicroscopy.·RESULTS:Conjunctivalhyperemia,cornealedema,intraocularpressureandanteriorchamberresponseofexperimentalandcontroleyesweresimilar,whilePCOinCsAMSinjectedeyeswasgreatlyimprovedcomparedwiththatincontroleyes.PosteriorcapsulesinCsA-MSinjectedeyesweresmoothandlensepithelialcells(LEC)didnotproliferatesignificantly(P>0.05),whileLECinposteriorcapsuleofcontroleyeshaddifferentdegreesofproliferationandcorticalregeneration.LECinCsA-MSinjectedeyeswerenotfunctionallyactiveandunderwentapoptosis,whereasLECincontroleyeswerefunctionallyactive(F-test,P=0.025).Inaddition,thecornealultrastructureshowednodifferencesbetweenCsA-MSandMSinjectedeyes.CONCLUSION:CsA-MShashighbioavailabilityinrabbiteyesandcouldinhibitpostoperativePCOoccurrenceanddevelopmentduringthestudyperiod,suggestingthatCsA-MSmaybeapromising,effectiveandsafeadministrationroutetopreventPCOinclinic.

简介：目的:通过测定糖尿病性白内障患者血清中糖代谢指标、胰岛素抵抗与房水和血清中炎症因子的水平,探讨其相关性。方法:随机选取我院2017-02/2018-01糖尿病性白内障患者69例(观察组)和白内障患者65例(对照组),检测两组患者血清中糖化血红蛋白(HbA1c)、空腹血糖(FPG)、空腹胰岛素(FINS)的水平,计算胰岛素抵抗指数(HOMA-IR);同时检测房水和血清中的胰岛素样生长因子-1(IGF-1)、白细胞介素-6(IL-6)含量,对HbA1c、HOMA-IR与房水和血清中IGF-1、IL-6含量进行相关性分析。结果:对照组血清中的FPG、HbA1c、HOMA-IR,以及房水和血清中IGF-1、IL-6含量显著低于观察组,差异有统计学意义(均P<0.05)。HbA1c与房水及血清中的IGF-1和IL-6均呈正相关(P<0.05)。HOMA-IR与房水及血清中的IGF-1和IL-6均呈正相关(P<0.05)。结论:糖尿病性白内障患者HbA1c、HOMA-IR与房水及血清中的IGF-1、IL-6含量具有相关性,通过对上述指标的测定可以辅助判断病情。

简介：目的：对湖北地区20～29岁人群的角膜散光情况与不同近视度数的关系进行调查,找出其变化规律。方法：用角膜地形图对随机抽取的2254例湖北地区20～29岁青年居民进行散光度、轴向及近视度数的测定,并分析其变化规律。结果：湖北地区20～29岁居民中,各个近视度段散光在26°～150°范围内所占人数比例最大,各个近视度段均呈现顺规散光人数多于逆规散光。其中女性高度近视段约为75.3%,中度近视段约为82.7%,低度近视段约为87.2%;男性高度近视段约为74.6%,中度近视段约为83.0%,低度近视段约为82.3%。20～29岁男性高度近视段顺规散光人数比例高于其他两组;女性低度近视段顺规散光人数比例低于其他两组,差异有统计学意义。20～29岁人群中女性中度近视段顺规散光人数比例高于同近视度男性组,且女性总体组顺规散光人数比例高于男性总体组,差异有统计学意义。20～29岁男、女性高度近视组200°以内散光人数比例均低于中度近视组,差异有统计学意义。结论：湖北地区20～29岁居民中,各个近视度段散光在26°～150°范围内所占人数比例最大,且各个近视度段不论男女均呈现顺规散光人数多于逆规散光;男性高度近视段顺规散光人数比例高于其他两组,女性低度近视段顺规散光人数比例低于其他两组;女性中度近视段顺规散光人数比例高于同近视度男性组,且女性总体组顺规散光人数比例高于男性总体组;男、女性高度近视组200°以内散光人数比例均低于中度近视组。

简介：Mostoftheoculartumorshavepoorprognosis,andtheyremainadifficultproblemintheareaofophthalmology.Withtherapiddevelopmentofmolecularbiologyandimmunologictechniquesandthedeepresearchonoculartumorrelatedgenes,itbecomespossibletodiagnoseandtreatmalignanttumorsfromthemolecularlevel.Thetumornecrosisfactorrelatedapoptosis-inducingligand(TRAIL),amemberofthetumornecrosisfactor(TNF)superfamily,isapromisingcandidate,eitheraloneorincombinationwithestablishedcancertherapies,sinceitcaninitiateapoptosisthroughtheactivationoftheirdeathreceptors.TheabilityofTRAILtoselectivelyinduceapoptosisoftransformed,virus-infectedortumorcellsbutnotnormalcellspromotesthedevelopmentofTRAIL-basedcancertherapy.Here,wewillreviewTRAILanditsreceptors’structure,function,mechanismofactionandapplicationinoculartumorstherapy.

简介：资料患者男性，51岁。因颈前痛及吞咽困难2d于2013年7月16日来我院急诊。患者2d前曾进食猪蹄，之后出现颈前根部梗阻感，伴咽部不适，喜进流质，易流口水。因患者自幼确诊为“21三体综合征”，平日言语表达不清，故家人未能带其及时就医。2d后上述症状加重，于我院行食管造影，结果显示：食管上段可见局部钡棉絮存留征象，双侧中下肺野支气管内钡剂存在（图1）。暂给予禁食、禁水、留院观察等处理。

简介：教育能够改变个人的生活,促进社会的变革。儿童在学校学习成绩的好坏,与他们的健康水平,包括视觉健康之间有着密切的联系。这反过来又影响到儿童未来的生活质量与经济生产力。学校的眼睛健康项目给上学儿童们提供了一个独一无二的机会,使他们能拥有全面的眼睛健康服务。

简介：·AIM:Tostudytheeffectsofdanhonghuayukoufuye(DHK)onfastingbloodglucose(FBG)anddiabeticretinopathy(DR)instreptozotocin(STZ)-inducedtype1diabeticratstofacilitatetherationalusageofthisdrug.·METHODS:DiabeticratswereinducedbyinjectionofasingledoseofSTZintraperitoneallyat50mg/kg.Flashelectroretinogram(FERG)andoscillatorypotentials(OPs)wereusedtomeasureretinalfunction.Themicrovascularperfusionofearswasperformedtostudythemicrocirculationinrats.FBG,body-weight,and24-hurinevolume,waterintakeanddietintakewerealsoassessed.·RESULTS:DHKhadnoeffectonFBGinnormalrats.However,STZ+DHKgroupweresignificantlydifferentfromthoseofModelandmovedtowardthoseofnormalcontrol.Itreversedtheincreaseindietintake(P≤0.05vsmodelcontrol)andthelossinbody-weight(P≤0.05vsmodelcontrol)indiabeticrats.DHKdecreasedtheFBGofdiabeticratsby25.6%(P≤0.05)and37.9%(P≤0.01)after14and21daysadministrationascomparedwiththemodelcontrol,respectively.Moreover,DHKsignificantlyincreasedtheFERGb-waveamplitudeby80%(P≤0.05vsmodelcontrol)anddecreasedtheFERGb-wavelatencyby15.3%(P≤0.01vsmodelcontrol)after24daysadministration.TheOP1andOP2amplitudesinDHKgroupwere2.6(P≤0.01)and2.0(P≤0.01)timesofmodelgroupafter24daysofDHKtreatment,respectively.Atthesametime,OP1andOP2latenciesinDHKgroupreducedby16.0%(P≤0.001)and14.7%(P≤0.001)ascomparedwiththemodelcontrol,respectively.Furthermore,themicrovascularperfusionofDHKgroupwas2.4timesofmodelgroup(P≤0.001)after21daysadministration.·CONCLUSION:DHKhadnoeffectonnormalFBG.Butithadantihyperglycemicactivity,andhadapreventiveandtherapeuticeffectonDRindiabeticrats.·

简介：AIM:Toanalyzetheapplicationofmicrobubblecontrasttechnologyinthetreatmentofophthalmicdiseases,mainlyanalyzingitsadvantagesandexistingproblems.METHODS:Atotalof30representativeliteraturesabouttheapplicationofultrasoundcontrastagentingenetargetedtherapyathomeandabroadwerecollected,andfocusingonsortingouttheliteraturereportingthetreatmentofophthalmicdiseaseswithmicrobubblecontrasttechnologyinrecentyears,thenrecallingitsadvantagesandproblems,finallymakingreasonableassessmentonexistingproblemsandproposingpossiblesolutionstotheproblems.RESULTS:Duetoitsuniquesafetyandefficacy,thetreatmentofophthalmicdiseaseswithmicrobubblecontrasttechnologyhasincreasinglydrawntheattentionofclinicians,buttworelevantissuesshouldbeconsidered:first,thenatureofcontrastagentandthechoiceofcorrespondingultrasoundparameters;second,relativeincidenceoftissuebleeding,intravascularhemolysis,moderateorsevereallergyaswellasothersideeffects.CONCLUSION:Microbubblemaybecomethecarrieroftargetedtherapy,andasakindofnewnon-invasivedeliverysystem,theultrasoundcontrastagenthasbroadapplicationprospects,butitsapplicationinophthalmicresearchisstillinitsinitialstageandthesafetyofcontrast-enhancedultrasoundstillneedsfurtherstudy.

简介：目的评价玻璃体切割术治疗眼球壁异物的效果。方法对我院2007年1月至2010年6月21例（21眼）眼球内壁异物行玻璃体切割联合异物取出的临床资料进行回顾分析。结果21例（21眼）均一次手术成功取出异物,伴有角膜裂伤、白内障、视网膜脱离及眼内炎者,均得到治愈。术后视力较术前增加者6眼（占28.6%）,不变者8眼（占38.1%）。术后1眼出现脉络膜脱离,1例出现视网膜脱离。结论玻璃体切割联合球壁异物取出,异物取出成功率高,同时治疗并发症,是治疗眼球内壁异物的较好选择。

简介：目的：探讨VEP技术在鉴别伪盲、评价伪盲眼实际视力水平方面的应用价值。方法：选取65例眼外伤后单眼盲或单眼低视力的患者为实验对象，将65只伤眼作为实验组，65只健眼作为对照组，分别行VEP检查。在VEP检查时，受检眼依次接受视角为30′、22′、11′、5′、3′的视觉刺激。结果：患眼主观视力与VEP视力不相符者48人，伪盲检出率为73．8％；对照组健眼VEP视力与主观视力符合率可达90．8％。结论：VEP技术能够准确评价受检眼的实际视力水平，并可为鉴别伪盲的法医学应用方面提供可靠依据。

简介：目的探讨后房型人工晶状体缝线固定术的临床效果。方法选取白2010年3月至2012年4月期间14例患者16眼,均采用后房型入工晶体睫状沟缝线固定术,术后随访3-23月。结果术后3个月复查时最佳矫正视力1.0,最低0.15,视力在0.5以上者9只眼（占56.2%）,视力偏低者中术前继发青光眼2只眼,玻璃体混浊2只眼,所有眼压均在正常范围内,无严重并发症发生结论人工晶状体睫状沟缝线固定术是治疗晶状体前囊膜口不完整,后囊膜破广较大或无囊膜,不能支撑后房型人工晶体患者的理想手术方法。