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简介：当员工失去工作热情与动力，高层主管们发觉经营理念不合，如果不及时阻止，企业可能就会陷入绩效滑落、组织猜忌、内耗的状况，身为经营者该如何扭转不利情势，重新创造一个公司赢、客户赢、主管赢、员工赢的多赢局面?

简介：在激光，微波和类似的技术的进展导致了包含皮组织的热治疗的最近的开发。这些处理的有效性被管理由联合了影响织物的热、机械、生物、神经的回答：一个有利相互作用相对小的疼痛和没有持续副作用地导致一个过程。当前，尽管每个行为的方面到建立并且理解的某个程度，任何一个都不在学科交差的区域存在到日期。一条高度学科交差的途径为学习皮肤的biothermomechanical行为被要求，包含简历热转移，简历力学和生理学。对这个题目恰当的全面文学评论在这篇论文被介绍，盖住四个题目区域：(a)皮肤结构，(b)皮肤简历热转移和热损坏，(c)皮肤简历力学，和(d)皮肤biothermomechanics。为进一步的研究的主要问题，问题，和话题也被构画出。这评论发现在每这些方面的重要进展在最近的年里被完成了。尽管焦点被放在皮肤织物的biothermomechanical行为之上，在这篇论文考察的基本概念和方法论可能也为学习另外的软纸巾是适用的。

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简介：取耳穴肺、风溪、神门、皮质下、肾上腺和大肠，以耳针配合常规方法治疗皮肤瘙痒症患者25例，以常规方法治疗25例为对照。结果两组疗效差别有统计意义，前者好于后者。

简介：Theobjectiveofthisstudywastoinvestigatetheeffectofgelatin(SG)isolatedfromsalmonskinanditshydrolysate(SGH)onphotoagingskin,andthemechanismresponsibleforanti-photoaging.TheaveragemolecularweightsofSGandSGHwere65kDaand873Da,respectively.TheaminoacidcompositionsofSGandSGHweresimilar.Bothofthemwereabundantinhydrophobicaminoacids.Twenty-fivepeptideswereidentifiedfromSGH.SGandSGHcouldimproveUVirradiation-inducedpathologicalchangesofmacroscopicaltissuetextureandskinmorphology.Hydroxyprolinecontentisanindicatorofmatrixcollagencontent,SGandSGHcouldinhibitthedecreaseofhydroxyprolinecontentinphotoagingskininadosedependentmanner.Inaddition,SGandSGHcouldalleviateUVirradiation-inducedoxidativedamagestoskinbyincreasingtheactivitiesoftotalsuperoxidedismutase(T-SOD),glutathioneperoxidase(GSH-Px)andcatalase(CAT),increasingthecontentofglutathione(GSH)anddecreasingthecontentofmalonaldehyde(MDA).Moreover,SGandSGHcouldenhanceimmuneregulationsystembyincreasingthethymusindex.Thus,theanti-photoagingmechanismsofSGandSGHwerebyinhibitingthedepletionofantioxidantdefensecomponents,involvinginthesynthesisofcollagenandenhancingthefunctionofimmunesystem.Besides,SGHshowedabetterresultinprotectingskinfromphotoagingthanSG.

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简介：AbstractSkin diseases were characterized by various types and high incidence, which seriously affect people’s health. At present, skin pathogenesis research and the therapeutic drug development for skin diseases are limited by the lack of reasonable research models that recapitulate the development of skin diseases. Organoids are three-dimensionally cultured cell populations derived from skin stem cells, which exhibits the ability of multicell assembly and the similar histological characteristics with the living tissues and organs. This article reviews the establishment of normal skin organoids and skin tumor organoids, and summarizes the application of skin organoids in the evaluation of drug sensitivity, pathological mechanism research, and individualized treatment. In addition, the advantages and limitations of organoids in skin disease research are also discussed, which provides a basis for revealing the pathogenesis of skin diseases and developing preventive and therapeutic drugs for skin diseases.

简介：Thesandfishisalizardhavingtheremarkableabilitytomoveindesertsandinaswimming-likefashion.Themostout-standingadaptationstothismodeoflifearethelowfrictionbehaviourandtheextensiveabrasionresistanceofthesandfishskinagainstsand,outperformingevensteel.Weinvestigatedthetopography,thecompositionandthemechanicalpropertiesofsandfishscales.Theseconsistofglycosylatedkeratinswithhighamountofsulphurbutnohardinorganicmaterial,suchassilicatesorlime.Remarkably,atomicforcemicroscopyshowsanalmostcompleteabsenceofattractiveforcesbetweenthescalesurfaceandasilicontip,suggestingthatthisisresponsiblefortheunusualtribologicalproperties.Theunusualglycosylationofthekeratinswasfoundtobeabsolutelynecessaryforthedescribedphenomenon.Thescalesweredissolvedandreconstitutedonapolymersurfaceresultinginpropertiessimilartotheoriginalscale.Thus,weprovideapathwaytowardsexploitationofthereconstitutedscalematerialforfutureengineeringapplications.

简介：THEFIRSTCASEofAIDSintheUSAwasrecognizedtwodecadesago,withtheearlycasesrepresentinghomosexualswithpneumocysticcariniipneumoniaorKaposi’ssarcoma.Sincethenthediseasehasspreadworldwidewithoutsparinganycontinent.HIVhascauseddeathsandseveresocio-economicimpactindevelopedandunderdevelopingcountries.

简介：Objective:Toinvestigatetheculturemethodofskin-derivedprecursors(SKPs)andtoexploreanewcellsourceforcelltransplantationofcentralnervoussystem.Methods:Cellsfromskinsofjuvenileandadultmicewereisolatedandculturedinserum-freemedium.Amechanicalmethodwaschosentopassagethesecellsandtheywereidemifiedbytheimmunocytochemistryassay.Results:SKPscouldbeisolatedfromadultandneonatalskins.Theycouldbemaintainedinvitroforlongperiodswithstableproliferation,andexpandedasundifferentiatedcellsincultureformorethan12passages.About50％ofSKPsexpressednestinandmajorityofthesecellsexpressedfibronectinwhentheywereplatedonpolyornithineandlaminincoatedplates.About5％cellsshowedneuronaldifferentiationandexpressedneurofilament-M(NF-M)andNSEwhenSKPswereplatedinserun-containingmedium,andthesecellscouldalsodifferentiateintoadipocytesandfibroblast-likecells.Conclusions:Thedatasupportthehypothesisthatadultskincontainsstemcellscapableofdifferentiatingintoneurons,adipocytes,andfibroblast-likecells.TheymayrepresentanalternativeautologousstemcellsourceforCNScelltransplantation.

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简介：Thereareseveralstudiesontheuseofskingrowthintissueculture,toknowhowtocoverlargesurfaceareasofburnpatientsandhowtoreplaceskinlossfromothertypeoftrauma.Itwouldbemostidealtohaveapermanentskinsubstitutecon-tainingdermalandepidermalcomposition.Thispaperdescribesthathumanepidermalcell(HEC)growthinvitrocanbecombinedwiththedegradeablebiomaterialsCollagen-ChitosanArtificialDermal(C-

简介：AbstractIntroduction:Primary systemic amyloidosis is characterized by clonal plasma cell disorder, and its signs and symptoms are various and complex, damage to the skin and mucous membrane is often more likely to attract attention.Here we reported a case of a 61-year-old male patient who presented with topical mucocutaneous lesion, as well unusual skin vegetations.Case presentation:A 61-year-old man was hospitalized due to repeated burning sensation on his back, multiple ecchymosis, and skin vegetations. Through a series of examinations (mainly including skin histopathology, bone marrow cytology, bone marrow flow cytometry, immunofixation electrophoresis), Primary systemic amyloidosis was diagnosed, but multiple myeloma could not be diagnosed. Subsequently, he received chemotherapy. In the half-year follow-up, there was no significant change in his symptoms and signs.Discussion:In this case, in addition to the typical skin damage of primary amyloidosis, the multiple skin vegetations in the buttocks, abdomen, and arms are particularly noteworthy. According to the histopathology and Immunohistochemistry of the skin vegetation, we infer that the formation mechanism of these skin vegetation is lymphatic obstruction caused by amyloid, which leads to lymphatic dilatation, lymph leakage, and dermal edema.Conclusion:Primary systemic amyloidosis is a rare disease, which is often difficult to diagnose. We should be alert to those atypical skin features so as not to delay diagnosis.

简介：您要知道解决色斑、皱纹、毛孔粗大和肌肤松弛等肌肤问题可不是一朝一夕就能达成目标的但是随着化妆品科技的进步，这个时间可以被缩短到1～2月之内成功的关键就在于要有针对性地选择正确的化妆品而且还要使用到足够的时间，现在我们就来分别介绍一下各种化妆品的有效功能

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简介：Anexperimentaltechniquehasbeendevelopedformeasuringandvisualizingstraindistributiononfacialskin.Astereovisiontechniquebasedondigitalimagecorrelationisemployedforobtainingthedisplacementdistributiononthehumanface.Time-variationofthemovementofthefacialskinsurfaceisobtainedfromconsecutiveimagesobtainedusingapairofhigh-speedcameras.Thestrainsonthefacialskinsurfacearethenobtainedfromthemeasureddisplacements.Theperformanceofthedevelopedsystemisdemonstratedbyapplyingittothemeasurementofthestrainonfacialskinduringtheproductionofsound.Resultsshowthatthestrainsonfacialskincanbevisualized.Furtherdiscussionontherelationshipbetweenthecreationofwrinklesandstrainsispossiblewiththehelpofthedevelopedsystem.