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简介：Lichimelange,locatedinthesoutherncoastalrange,easternTaiwan,China,isatypicaltectonicmelangeoftheplate'sboundaryzonebetweentheEurasianPlateandthePhilippineSeaPlate.ItformedduringthecollisionoftheLuzonarcwiththeEurasianContinent(arc-continentcollision).Itiscomposedofsandstoneand/ormudstonematrixandmanykindsandsizesofrockfragments,includingsomesedimentaryrocks,volcanicrocksandafewmetamorphicrocks.TheserpentiniteisoneofthecommonfragmentsintheLichimelange.BythepetrographiccharacteristicsandthezirconU-Pbchronologyanalyses,protolithoftheserpentiniteisperidotite,theageis17.7±0.5Ma.Takingthetectonicbackgroundintoaccount,itisinferredthattheserpentinite(serpentinisedperidotite)comefromtheforearcbasin(theNorthLuzonTrough)andwastakenintothemelangebyasecondthrustwestwards.TheoriginoftheserpentimteinLichimelangeishelpfultounderstandtheformationoftheLichimelangeandcanprovidereliabledetailedinformationforthestudyofthearc-continentcollisionorogenicactivityinandoffshoreTaiwan.

简介：N^6-methyladenosine(m^6A)isanessentialRNAmodificationthatregulateskeycellularprocesses,includingstemcellrenewal,cellulardifferentiation,andresponsetoDNAdamage.Unsurprisingly,aberrantm6Amethylationhasbeenimplicatedinthedevelopmentandmaintenanceofdiversehumancancers.Alteredm6AlevelsaffectRNAprocessing,mRNAdegradation,andtranslationofmRNAsintoproteins,therebydisruptinggeneexpressionregulationandpromotingtumorigenesis.Recentstudieshavereportedthattheabnormalexpressionofm6Aregulatoryenzymesaffectsm6Aabundanceandconsequentlydysregulatestheexpressionoftumorsuppressorgenesandoncogenes,includingMYC,SOCS2,ADAM19,andPTEN.Inthisreview,wediscussthespecificrolesofm6A“writers",“erasers”,and“readers”innormalphysiologyandhowtheiralteredexpressionpromotestumorigenesis.Wealsodescribethepotentialofexploitingtheaberrantexpressionoftheseenzymesforcancerdiagnosis,prognosis,andthedevelopmentofnoveltherapies.

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简介：在中国的江苏海岸定位的光线的沙山脉系统(RSRS)为它的特殊结构和潜在的陆地资源在它形成的起源和技工上吸引许多注意。由于复杂水动力学状况，江苏RSRS是一热在它的潜在的来源，长江或黄河上辩论了吗？我们在夏天从现代黄河河口沿着Bohai海和黄海的西方海岸从表面沉积收集了十件沙样品到长江河口，2013。样品被由岩屑形成的锆石年龄的方法为RSRS沉积的来源鉴定分析。样品的由岩屑形成的锆石谷物的U-Pb年龄系列从新生代显示出一个宽范围到与几座年龄山峰晚太古代。比较在长江和黄河之间的年龄系列，由岩屑形成的锆石有更年轻的年龄(<100妈)在长江的组。江苏沿海的RSRS沉积的这些年龄分发类似于长江的，但是与黄河不同。邻近旧黄河三角洲的定位的样品显示出更宽范围的年龄分发，暗示来自两条河的加重的起源。把调查结果基于这些与普通意见相反，江苏RSRS的主要沉积来源是长江，而非黄河，这被建议。由牵连，应该有海洋的水流和潮汐的运动的水动力学力学的证据。这个方面在未来研究等候证实。