简介：BackgroundCentralaorticsystolicbloodpressure(CASP)hasbeenshowntobeastrongerpredictoroftarget-organdamageandcardiovasculareventsthanbrachialsystolicbloodpressure(BSBP),buttherewasnodataaboutwhetherCASPcanpredictprolongedQRSdurationmorethanBSBP.WeexaminedtheassociationofCASPandBSBPwithQRSdurationinruralcommunityresidents.MethodsWeretrospectivelyanalyzed490ruralcommunityresidents.Standardresting12-leadECGandcentralaorticbloodpressure(CABP)weremeasurednoninvasivelyinallsubjectsatbaseline.TheQRSdurationwasequaltoormorethan120msbeingdefinedasprolongedQRSduration.ResultsTheprolongedQRSdurationgroupshowedhigherCASP(139.38±11.67vs.135.36±16.22,P=0.031)andBSBP(136.03±6.74vs.124.44±13.01,P<0.001)ascomparedwithcontrols.MultivariatelinearregressionanalysisshowedthatCASP,BSBPandheartratewereindependentlyaffectingQRSduration.LogisticregressionanalysesshowedthatCASP(OR1.057,95%CI:1.027,1.088,P<0.001)andBSBP(OR1.056,95%CI:1.027,1.086,P=0.032)wereindependentpredictorsofprolongedQRSdurationafteradjustmentforage,sex,bodymassindex,heartrate.CASPhadabetterpredictivevalueforprolongedQRSdurationthan(AUC:0.793vs.0.601,P<0.001)BSBP.ConclusionsOurfindingsdemonstratethatbothCASPandBSBParerisksforprolongedQRSduration,butCASPcanpredictprolongedQRSdurationbetterthanBSBP.

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简介：Newtonian,QuemadaandCassonbloodviscositymodelsareimplementedinordertosimulatetherheologicalbehaviorofbloodunderpulsatingflowconditionsinapatientspecificiliacbifurcation.Theinfluenceoftheappliedbloodconstitutiveequationsismonitoredviathewallshearstress(WSS)distribution,magnitudeandoscillations,non-Newtonianimportancefactors,andviscosityvaluesaccordingtotheshearrate.ThedistributionofWSSonthevascularwallfollowsapatternwhichisindependentoftherheologicalmodelchosen.Ontheotherhand,theWSSmagnitudeandoscillationsaredirectlyrelatedtothebloodconstitutiveequationsappliedandtheshearrate.ItisconcludedthattheNewtonianapproximationissatisfactoryonlyinhighshearandflowrates.Moreover,theNewtonianmodelseemstooverestimatethepossibilityfortheformationofatheroscleroticlesionsoraneurysmsatsitesofthevascularwallwheretheWSSareoscillating.

简介：InthisLetter,aminiaturewearableRamanspectroscopysystemisdeveloped.Awearablefiber-opticprobeiemployedtohelpthestableandconvenientcollectionofRamanspectra.Anonlinearpartialleastsquaresmodebasedonamultivariatedominantfactorisemployedtopredicttheglucoselevel.Themeancoefficientsofdeterminationare0.99,0.893,and0.844fortheglucosesolution,laboratoryrats,andhumanvolunteers.ThresultsdemonstratethataminiaturewearableRamanspectroscopysystemisfeasibletoachievethenoninvasivdetectionofhumanbloodglucoseandhasimportantclinicalapplicationvalueindiseasediagnosis.

简介：PurdueUniversityresearchershavefoundamethodofidentifyingbiologicalmarkersinsmallamountsofbloodthattheybelievecouldbeusedtodetectamyriadofdiseases,infectionsanddifferentmedicalconditionsatearlystages.Apiezoelectricallyactuatedpipettesystemisusedasaninexpensivemeanstodetectbiologicalmoleculesassociatedwithspecificdiseases,infectionorother

简介：Purpose:Thepurposeofthisstudywastoinvestigatetheeffectsofobesityandhigh-intensityacuteexerciseonoxidant-antioxidantstatus,neurotrophicfactorexpression,andblood-brainbarrier(BBB)disruption.Methods:Twenty-fourhealthy,untrainedmen(12non-obese(mean14.9%bodyfat)and12obesesubjects(mean29.8%bodyfat))performed20minofcontinuoussubmaximalaerobicexerciseat85%maximaloxygenconsumption.Bloodsamplingwasperformedtoexaminetheoxidant-antioxidantstatus(reactiveoxygenspecies(ROS)andsuperoxidedismutase(SOD)),neurotrophicfactors(brain-derivedneurotrophicfactor(BDNF)andnervegrowthfactor(NGF)),andBBBdisruption(S100βandneuron-specificenolase)beforeandafteracuteexercise.Results:Theobesegroupshowedsignificantlyhigherpre-exerciseserumROSlevelsandsignificantlylowerpre-exerciseserumSODlevelsthanthenon-obesegroup(p<0.05).SerumROS,SOD,BDNF,NGF,andS100βlevelsweresignificantlyincreasedpost-exercisecomparedwithpre-exerciselevelsinboththenon-obeseandtheobesegroups(p<0.05).TheobesegroupshowedsignificantlyhigherserumROS,BDNF,NGF,andS100βlevelspost-exercisecomparedtothenon-obesegroup(p<0.05).Conclusion:OurstudysuggeststhatepisodicvigorousexercisecanincreaseoxidativestressandbloodneurotrophicfactorlevelsandinducedisruptionoftheBBB.Moreover,highlevelsofneurotrophicfactorinthebloodafterexerciseintheobesegroupmaybeduetoBBBdisruption,anditisassumedthatoxidativestresswasthemaincauseofthisBBBdisruption.

简介：BackgroundInpatientswithacutecoronarysyndrome(ACS),loweradmissionsystolicbloodpressure(SBP)levelsinferaworseprognosis.However,thepredictivepotentialofadmissionSBPon1-yearmortalityhasnotfullyelucidatedinpatientswithnon-ST-segmentelevationACS(NSTEACS).MethodsWeenrolled1325patientstoinvestigatetheassociationbetweenadmissionSBPinpatientshospitalizedforNSTEACS.WeanalyzedtheassociationbetweenadmissionSBPand1-yearmortality.AdmissionSBPwascategorizedaslow(<110mmHg),normal(110-140mmHg),high(141-160mmHg),andveryhigh(>160mmHg).ResultsComparedwithpatientswithnormaladmissionSBP,thosewithlowSBPhadasignificantlyincreasedhazardratios(HRs)for1-yearmortalityof3.03(P<0.05),whilepatientswithhighandveryhighadmissionSBPhadnosignificantlyincreasedHRsfor1-yearmortality.ConclusionLowadmissionSBP,butnotelevatedadmissionSBP,isastrongindependentpredictorof1-yearmortalityinpatientswithNSTEACS.

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