简介：AbstractGastric cancer (GC) is one of the most common malignant tumors. The mechanism of how GC develops is vague, and therapies are inefficient. The function of microRNAs (miRNAs) in tumorigenesis has attracted the attention from many scientists. During the development of GC, miRNAs function in the regulation of different phenotypes, such as proliferation, apoptosis, invasion and metastasis, drug sensitivity and resistance, and stem-cell-like properties. MiRNAs were evaluated for use in diagnostic and prognostic predictions and exhibited considerable accuracy. Although many problems exist for the application of therapy, current studies showed the antitumor effects of miRNAs. This paper reviews recent advances in miRNA mechanisms in the development of GC and the potential use of miRNAs in the diagnosis and treatment of GC.

简介：摘要微小RNAs(miRNAs)是一种内源性短链RNA，长度约22 nt，具有高度保守性，不具备编码作用。成熟的miRNAs通过与目标基因3′端非翻译区特异性结合发挥作用，在转录后水平降解该基因的mRNAs或阻碍其翻译，从而负性调控目标基因表达而发挥生物学功能。近年来，miRNAs在心血管疾病中的研究日益深入，大量证据显示，miRNAs在许多心血管疾病发病机制中发挥作用，也将成为潜在的心血管疾病诊断与预后评价的标志物和新的治疗靶点。

简介：摘要微小RNAs(miRNAs)是一种高度保守的短链非编码RNA，在分子层面上调控生命活动。miRNAs活跃在缺血性脑卒中后自噬的各个阶段，发挥着脑保护作用和破坏作用。本文以自噬过程为线索，围绕自噬相关基因(Atg)或通路探讨miRNAs调控自噬在缺血性脑卒中中的可能作用机制进行综述，分析其在脑卒中诊疗中的应用前景。