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  • 简介:OneofthemostsignificantrecentdevelopmentsinmusicologyhasbeenthetranscriptionandinterpretationofcertainmusicalcuneiformtextsdatingfromthesecondmillenniumBC.IthasbeenestablishedthatOldBabylonianmusicwasdiatonicandprobablybasedonsevenheptachords,correspondingtothefirstseventonesoftheancientGreekoctavespecies.However,thereremainsaproblem:thereissomeambiguityinthetextsaboutwhetherthescalesshouldberisingorfalling,andtheirnomenclaturechangingaccordingtowhichdirectionischosen.Thisarticlesuggestsapossibleresolutionofthedifficulty.OntheassumptionthatOldBabyloniantheoreticiansmighthavequantifiedtheirscales,thearticlearithmetizesthetuningproceduresofthetwomaincuneiformtuningtextstogether,asasingleprocess,andtherebyalsodemonstratestheplausibilityofthehypothesisthattheidealizedmodelforBabyloniantuningwouldbelikelytohavebeenJusttuningratherthanPythagoreantuning,ashasbeengenerallyassumed.

  • 标签: 古巴比伦 古代音乐 音乐研究 传统文化
  • 简介:AbstractThe developmental origins of health and disease theory states that environmental stresses during the early stages of life influence health and risk of developing non-communicable diseases throughout the lifespan of an individual. Developmental plasticity is thought to be a possible underlying mechanism. Here, I discuss a contrasting but complementary genetic hypothesis regarding the developmental origins of health and disease theory: crosstalk between the genomes of the parents and offspring is responsible for shaping and adapting responses to environmental stresses, regulating early growth and predisposition to non-communicable diseases. Genetic variants that are beneficial in terms of responses to early life stresses may have pleiotropic detrimental effects on health later in life, which may change the allele frequencies driven by selection on a population level. Genetic studies on the cohort of children born after assisted reproduction could provide insight regarding the genetic mechanisms of the developmental origins of health and disease theory.

  • 标签: assisted reproduction DOHaD genetic pleiotropy non-communicable diseases positive selection
  • 简介:TheresearchesonCriticalPeriodHypothesis(CPH)aimstoexplaintheimportanceoftheagefactorintheprocessoflearningasecondlanguage.Inthisessay,acriticalreviewofthetheoreticalissuesandempiricalresearchontheCPHwillspreadout.Meanwhile,thediscussionofimplicationandlimitationoftheCPHresearchwillbeconcernedaswell.

  • 标签: CRITICAL PERIOD HYPOTHESIS SECOND LANGUAGE ACQUISITION
  • 简介:Stableisotopesofmostimportantbiologicalelements,suchasC,H,NandO,affectlivingorganisms.Inrapidlygrowingspecies,deuteriumandtoalesserextentotherheavyisotopesreducethegrowthrate.Atleastfordeuteriumitisknownthatitsdepletionalsonegativelyimpactsthespeedofbiologicalprocesses.Asarule,livingorganisms'resist'changesintheirisotopicenvironment,preferringnaturalisotopicabundances.Thispreferencecouldbeduetoevolutionaryoptimization;anadditionaleffectcouldbeduetothepresenceofthe'isotopicreso-nance'.Theisotopicresonancephenomenonhasbeenlinkedtothechoiceofearliestaminoacids,andthusaffectedtheevolutionofgeneticcode.Totesttheisotopicresonancehypothesis,literaturedatawereanalyzedagainstquantitativeandqualitativepredictionsofthehypothesis.Fourstudiesprovidedfiveindependentdatasets,eachinverygoodquantitativeagreementwiththepredictions.Thus,theisotopicresonancehypothesisisnolongersimplyplausible;itcannowbedeemedlikely.Additionaltestingisneeded,however,beforefullacceptanceofthishypothesis.

  • 标签: 稳定同位素 同位素测试 共振现象 假说 生活 同位素丰度
  • 简介:AHYPOTHESISONTHEEFFECTOFCORIOLISFORCEONTHEDEVELOPMENTOFRIGHT-LEFTASYMMETRYOFMAMMALSAHYPOTHESISONTHEEFFECTOFCORIOLISFORCEONTHE...

  • 标签: CORIOLIS force the right-left asymmetry of
  • 简介:Inthispaper,weaimatdynamicalbehaviorsofastochasticSISepidemicmodelwithdoubleepidemichypothesis.Sufficientconditionsfortheextinctionandpersistenceinmeanarederivedviaconstructingsuitablefunctions.WeobtainathresholdofstochasticSISepidemicmodel,whichdetermineshowthediseasesspreadwhenthewhitenoisesaresmall.Numericalsimulationsareusedtoillustratetheefficiencyofthemainresultsofthisarticle.

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  • 简介:Thehumanfootisaverycomplexstructurecomprisingnumerousbones,muscles,ligamentsandsynovialjoints.Astheonlycomponentincontactwiththeground,thefootcomplexdeliversavarietyofbiomechanicalfunctionsduringhumanlocomotion,e.g.bodysupportandpropulsion,stabilitymaintenanceandimpactabsorption.Theseneedthehumanfoottoberigidanddampedtotransmitgroundreactionforcestotheupperbodyandmaintainbodystability,andalsotobecompliantandresilienttomoderateriskyimpactsandsaveenergy.Howdoesthehumanfootachievetheseapparentconflictingfunctions?Inthisstudy,weproposeaphase-dependenthypothesisfortheoveralllocomotorfunctionsofthehumanfootcomplexbasedonin-vivomeasurementsofhumannaturalgaitandsimulationresultsofamathematicalfootmodel.Wepropsethatfootfunctionsarehighlydependentongaitphase,whichisamajorcharacteristicsofhumanlocomotion.Inearlystancejustafterheelstrike,thefootmainlyworksasashockabsorberbymoderatinghighimpactsusingtheviscouselasticheelpadinbothverticalandhorizontaldirections.Inmid-stancephase(~80%ofstancephase),thefootcomplexcanbeconsideredasaspringyrocker,reservingexternalmechanicalworkusingthefootarchwhilstmovinggroundcontactpointforwardalongacurvedpathtomaintainbodystability.Inlatestanceafterheeloff,thefootcomplexmainlyservesasaforcemodulatorlikeagearbox,modulatingeffectivemechanicaladvantagesofankleplantiflexormusclesusingmetatarsal-phalangealjoints.Asoundunderstandingofhowdiversefunctionsareimplementedinasimplefootsegmentduringhumanlocomotionmightbeusefultogaininsightintotheoverallfootlocomotorfunctionsandhencetofacilitateclinicaldiagnosis,rehabilitationproductdesignandhumanoidrobotdevelopment.

  • 标签: 生物力学 人脚 运动模式 减震器
  • 简介:Hypothesistestingfortheparametriccomponentinthepartiallinearerrors-in-variables(EV)regressionmodelsisdiscussedinthispaper.Basedonthecorrectedprofileleastsquareestimator,fiveteststatisticsareproposedandtheasymptoticnulldistributionsofthemarededuced.Simulationshavebeendonetoshowtheperformanceoftheseteststatisticsundernullandalternativehypothesis.

  • 标签: 线性模型参数 假设检验 最小二乘估计 检验统计量 检验问题 回归模型
  • 简介:Throughanoverviewofdevelopmentsinfinanceandintheenergysector,thisworkrepresentsananalysisoftherelationshipoftheirtrends.Itiscarriedoutthroughaninterdisciplinaryapproach.Fromtheoriginalphysicalcurrencytoelectronicpaymentmethods,digitalcurrencyisbecominganewconcept.It’sstillafiatmoneywhichisonlyasgoodastheorganizationthatissuesit.BecauseBitcoinisnotissuedbyanycentralbank,thereisnocentralizedmanagementofthecountry;thereisagreatriskoflosingcontrol.Financeisnotentirelyavirtualeconomy.So,currencydevelopmenttrendsmustreturntointrinsicvalue.Thereisthepossibilityfortheenergycurrencyalsoforitsstability.Asanenergycurrency,itisnotnecessarytoprint,nottoapplytheexchangerate,nocorrespondingpollution,andevenbetteritwillhelptoalleviatetheexistingenvironmentalproblemfacingthechallengesofglobalenvironmentaldegradation.Theinternationalunitofenergycanbeseenastheunitofenergymoneybecauseofitsintrinsicvalue.AsstatedbyScott,therearegoodreasonstoconsiderenergyasapotentialcurrency.Ifthefutureintegratesenergyintothefinancialsystemandbecomesameansofpayment,itwillnotonlyeliminatetheriskofcurrencydepreciation,butalsooptimizeenergysavingandusetoachieveenvironmentalprotection.Theemphasisisgiventotheintegrationofthefinancialsectorwiththeenergyone.Theaimistodevelopaparametricnumericalmodelabletoforeseethepossibilityofcombiningfinanceandenergy,allowingasustainabledevelopment.Thisallowsustoanalyzetheprosandconsoftheexistingenergycryptocurrencies.Thelaststepconsistsinidentifyingthemaincharacteristicsthatthiscryptocurrencymusthaveinordertoachievethedesiredresults.

  • 标签: cryptocurrency development INTEGRATION FINANCE ENERGY INNOVATION
  • 简介:CoriolisForceisthePrimaryCauseofRight-leftAsymmetry.Ananimalmov-ingontheNorthernHemispherebearsCoriolisforcewhichisperpendiculartothevelocityofthemotionandwhichpointstotherightoftheanimal.Thisright-direct-ingforcewillbedenotedbyFc.Itactsthroughoutthelifeofananimal;indeed,throughoutthelivesofallofitsancestors,fromthefetaltoadultstagesineverypartofthebody.Let’sconsiderfirstabodywithtwolegsslidingonearth.Therightlegwouldsustainalargerforcethantheleftleg.Acomplexsystemofmus-

  • 标签: sustain CORIOLIS fetal sliding LIVES indeed
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