简介：1950年英国的Barrett首先报道，食管远段有内村柱状上皮的溃疡，认为溃破的内村柱状上皮组织属于先天性短内衬鳞状上皮食管病人的胃管状节段。此管状结构是食管下段内村柱状上皮，这种现象称为BE。现在普遍认为：BE是指食管下段的复层群状上皮被单层柱状上皮替代的一种病理现象。若在这种病变的基础上发生边界分明的打洞样溃疡，称之为Barrett溃疡。有时两者通称为BE。l病因与发病机理BE的病因及发病机制一直有争议。目前较公认的学说有两种。l．l先天性发生学说：认为BE是由胚胎期食管上皮发有障碍引起。食管从前肠演变而来，在形成初期，表面覆有单层往状上皮，大约八胚胎第16周起往状上皮逐渐为复层群状上皮所

简介：Serumspermidinewasassayedbyradioimmuno-assayindifferentstagesofesophagealcarcinogenesisinthepopulationfromhighriskareaofesophagealcancer,LinxianCounty.Theserumspermidinevalueswere76.94+74.38ngmlin36normalindividuals;115.71+113.45ng/mlin35patientswithmarkedepithelialhyperplasia(MEH)and294.48+135.36ng/mlin31patientswithearlyesophagealcancer.PatientswithMEHweregiveninterventiontreatmentbyAminoretinoicEsterorAnticancerBorplacebo(starch)ascontrols.Oneyearlater,samplesfromthepopulationwerecollectedagainforserumspermidinemsasurement.Thevalueswere95.8+68.2ng/mlin27normals;125.1±72.9ng/mlin62patientswithMEHtreatedbyAnticancerB;125.6±117.2ng/mlin64patientswithMEHtreatedbyAminoretinoicEster;162.4±76.6ng/mlin62controlsand210.5±182.9ng/mlin44patientswithearlyesophagealcancer.Theresultsshowedthatspermidineradioim-munoassaycouldreflectthetendencyofesophagealprecancerous

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简介：AIM:Toinvestigatethelifetimeriskofdevelopmentofesophagealadenocarcinomaand/orhigh-gradedysplasiainpatientsdiagnosedwithBarrett’sesophagus.METHODS:DatawereextractedfromtheUnitedKingdomNationalBarrett’sOesophagusRegistryondateofdiagnosis,patientageandgenderof7877patientsfromwhohadbeenregisteredfrom35UnitedKingdomcenters.LifeexpectancywasevaluatedfromUnitedKingdomNationalStatisticsdatabasedupongenderandageatyearatdiagnosis.Thesedatawerethenusedwithpublishedestimatesofannualadenocarcinomaandhigh-gradedysplasiaincidencesfrommetaanalysesandlargepopulation-basedstudiestoestimateoveralllifetimeriskofdevelopmentofthesestudyendpoints.RESULTS:ThemeanageatdiagnosisofBarrett’sesophaguswas61.6yearsinmalesand67.3yearsinfemales.Themeanlifeexpectancyatdiagnosiswas23.1yearsinmales,20.7yearsinfemalesand22.2yearsoverall.Usingdatafrompublishedmeta-analyses,thelifetimeriskofdevelopmentofadenocarcinomawasbetween1in8and1in14andthelifetimeriskofhigh-gradedysplasiaoradenocarcinomawas1in5to1in6.Usingdatafrom3largerecentpopulation-basedcohortstudiesthelifetimeriskofadenocarcinomawasbetween1in10and1in37andofthecombinedendpointofhigh-gradedysplasiaandadenocarcinomawasbetween1in8and1in20.AgeatBarrett’sesophagusdiagnosisisreducingandlifeexpectancyisincreasing,whichwillpartiallycounter-balancelowerannualcancerincidence.CONCLUSION:Thereisasignificantlifetimeriskofdevelopmentofhigh-gradedysplasiaandadenocarcinomainBarrett’sesophagus.

简介：瞄准：为了在Sprague-Dawley的远侧的食管分析microbiota移动，老鼠喂了一本高脂肪的食谱。方法：二十只Sprague-Dawley老鼠各被划分成高脂肪的饮食和10只老鼠的正常控制组。在从远侧的食管的mucosa的microbiota的作文基于选择文化被分析。许多乳杆菌种类被分子的生物技术识别。从乳杆菌殖民地的细菌的DNA被提取，并且16SrDNA被PCR用细菌的通用教材放大。放大16SrDNA产品被使中毒分开坡度胶化电气泳动(DGGE)。每个单身的乐队从胶化被净化并且送了被定序。结果：在远侧的食管把细菌的culturing基于mucosal，葡萄球菌aureus不在、全部厌氧微生物和乳杆菌种类与正常控制组相比在高脂肪的食谱组显著地被减少(P<0.01)。在远侧的食管的乳杆菌种类的作文上的详细DGGE分析揭示了那乳杆菌crispatus，乳杆菌gasseri(L。gasseri)并且乳杆菌reuteri(L。reuteri)在高脂肪的食谱组包括了乳杆菌种类，当在正常控制组的乳杆菌种类的作文由L组成了时。gasseri，乳杆菌jensenii和L。reuteri。结论：高脂肪的饮食在老鼠在远侧的食管导致了mucosalmicroflora移动，特别乳杆菌种类的作文。