简介：我们为解决三凸的可分离的功能的和的最小化建议了一个最初双的固定的点算法(PDFP)，它与Lipschitz连续坡度，线性合成nonsmooth功能，和nonsmooth功能包含光滑的功能。与类似的工作相比，在PDFP的参数更容易选择并且在一个相对更大的范围被允许。我们将扩大PDFP解决二种可分离的多块最小化问题，在信号处理和成像科学产生。这个工作显示出把PDFP算法用于多块问题的灵活性并且说明实际、充分切开的计划怎么能被导出，特别为大规模问题的平行实现。连接和比较到轮流出现的方向方法(ADMM)更多样地也是现在。我们表明不同算法怎么能被通过稀少的经典例子以不同方法切开这些问题获得有限制的调整最不方形的模型。特别地，在多块ADMM的上下文为线性地抑制的问题，它具有伟人的一个班感兴趣，能被PDFP也与集中的一条保证解决。最后，一些实验被提供说明PDFP算法导出的几个计划的表演。

简介：Onthebasisoftheformulationsofthelogarithmicbarrierfunctionandtheideaoffollowingthepathofminimizersforthelogarithmicbarrierfamilyofproblemsthesocalled"centralpath"forlinearprogramming,weproposeanewframeworkofprimal-dualinfeasibleinteriorpointmethodforlinearprogrammingproblems.Withoutthestrictconvexityofthelogarithmicbarrierfunction,wegetthefollowingresults:(a)ifthehomotopyparameterμcannotreachtozero,thenthefeasiblesetoftheseprogrammingproblemsisempty;(b)ifthestrictlyfeasiblesetisnonemptyandthesolutionsetisbounded,thenforanyinitialpointx,wecanobtainasolutionoftheproblemsbythismethod;(c)ifthestrictlyfeasiblesetisnonemptyandthesolutionsetisunbounded,thenforanyinitialpointx,wecanobtaina(?)-solution;and(d)ifthestrictlyfeasiblesetisnonemptyandthesolutionsetisempty,thenwecangetthecurvex(μ),whichtowardstothegeneralizedsolutions.

简介：内核函数在为解决线性优化问题为最初双的内部点的算法定义新搜索方向起一个重要作用。在这篇论文我们在场与最好已知的复杂性产出一个算法的新核功能为大更改、小更改的方法跳了。

简介：在这份报纸，我们建议二新不安单一的变体。没有介绍人工的变量，解决线性编程问题，二的各个使用双枢规则完成最初的可行性，然后最初的枢规则完成optimality。第二个算法，修正第一，被设计更高效地处理高度退化的问题。有关不安的优点的一些有趣的结果被建立。从初步的测试的数字结果也被报导。[从作者抽象]

简介：在有限领域上的排列代码被介绍，为自我双的排列代码的存在或不存在的一些条件被获得。

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简介：AbstractBismuth-containing quadruple therapy (BQT) has long been recommended for Helicobacter pylori (H. pylori) eradication in China. Meanwhile, in the latest national consensus in China, dual therapy (DT) comprising an acid suppressor and amoxicillin has also been recommended. In recent years, the eradication rate of H. pylori has reached >90% using DT, which has been used not only as a first-line treatment but also as a rescue treatment. Compared with BQT, DT has great potential for H. pylori eradication; however, it has some limitations. This review summarizes the development of DT and its application in H. pylori eradication. The H. pylori eradication rates of DT were comparable to or even higher than those of BQT or standard triple therapy, especially in the first-line treatment. The incidence of adverse events associated with DT was lower than that with other therapies. Furthermore, there were no significant differences in the effects of dual and quadruple therapies on gastrointestinal microecology. In the short term, H. pylori eradication causes certain fluctuations in the gastrointestinal microbiota; however, in the long term, the gastrointestinal microbiota eventually returns to its normal state. In the penicillin-naïve population, patients receiving DT have a high eradiation rate, better compliance, lower incidence of adverse reactions, and lower primary and secondary resistance to amoxicillin. These findings suggest the safety, efficacy, and potential of DT for H. pylori eradication.

简介：Thedualrandommodelsaboutthelifeinsuranceandsocialpensioninsurancehavereceivedconsiderableattentionintherecentarticlesonactuarialtheoryandapplications.Thispaperdiscussesageneralkindofincreasingannuitybasedonitsforceofinterestaccumulationfunctionasageneralrandomprocess.Thedualrandommodelofthepresentvalueofthebenefitsoftheincreasingannuityhasbeenset,andtheirmomentshavebeencalculatedundercertainconditions.

简介：Inthispaper,thedualmixedmethodforanunilateralproblem,whichisthesimplifiedmodellingofscalarfunctionforthefriction-freecontactproblem,isconsidered.Thedualmixedproblemisintroduced,theexistenceanduniqenessofthesolutionoftheproblemarepresented,anderrorboundsO(h^3/4)andO(h^3/2)areobtainedforthedualmixedfiniteelementapproximationsofRaviart-Thomaselementsfork=0andk=1respectively.

简介：Duetothegoodperformanceoftrackinglowelevationtargetascomparedtomicrowaveandthesuperiorityinpenetratingsmoke,dust,fog,anddrysnowascomparedtoinfrared,aKuandKadualbandexperimentalradarwasdesignedanddeveloped.ThisKuandKadualbandexperimentalradarisanarnplitute-comparisonmonopulsetrackingandguidingradar.Theconstitutionandparametersofthisradarisdescribedinparagraph2.Paragraph3dealswithtwoexperimentsfortestingthetrackingperformancesagainstlowelevationtarget,andgivestheimportantresults.BothKuandKabandhavehightrackingprecisionwhentheytrackhighelevationtargets,whileKabandhasmuchbettertrackingperformancethanKubandwhentheytracklowelevationtargets.Kabandcantrackahelicopter,whoseradarcrosssectionisabout6squaremeters,at40m,20m,10m,andeven5mabovesea.Kubandcanonlytrackthesamehelicopterat160mandhigherabovesea.

简介：Thispapergivesanewdualproblemfornondifferentiableconvexprogrammingandprovesthepropertiesofweakdualityandstrongdualityandoffersanecessaryandsufficientconditionofstrongduality.

简介：Thepurposeofthispaperistopresentsomedualpropertiesofdualcomodule.Itturnsoutthatdualcomodulehasuniversalproperty(cf.Theorem2).Since(()*,()°)isanadjointpair(cf.Theorem3),somenicepropertiesoffunctor()°areobtained.FinelyTheoram4providesthatthecotensorproductisthedualofthetensorproductby(MAN)°≌M°□A.N°.Moreover,theresultHomA(M,N)≌Coma.(N°,M°)isprovedforfiterelatedmodulesM,NoverarefiexivealgebraA.

简介：Apotentialdualinhibitor(4)forexogenousabsorptionandendogenicsynthesisofcholesterolwasdesignedbasedontheconjugationoftheβ-lactampharmacophoreofezetimibeandtheδ-lactonepharmacophoreofstatins.Themergerofezetimibeandstatin4wassynthesizedfromp-hydroxybenzaldehydethroughaten-steproute.1HNMRanalysisshowedexistenceoffourpairsofenantiomers(5.7:5.7:1:1,molarratio).Andcompound4wasfoundtolowertotalglucose(TG)levelinratserumviaahigh-cholesterolandhigh-fatfeedingexperiment.

简介：Theuniquecharacteristicsofgas-solidstwo-phaseflowandfluidizationintermsoftheflowstructuresandtheapparentbehaviorofparticlesandfluid-particleinteractionsarecloselylinkedtophysicalpropertiesoftheparticles,operatingconditionsandbedconfigurations.Fluidizedbedsbehavequitedifferentlywhensolidproperties,gasvelocitiesorvesselgeometriesarevaded.Anunderstandingofhydrodynamicchangesandhowthey,inturn,influencethetransferandreactioncharacteristicsofchemicalandthermaloperationsbyvariationsingas-solidcontact,residencetime,solidcirculationandmixingandgasdistributionisveryimportantfortheproperdesignandscale-upoffluidizedbedreactors.Inthispaper,ratherthanattemptingacomprehensivesurvey,weconcentrateonexaminingsomeimportantpositiveandnegativeimpactsofparticlesizes,bubbles,clustersandcolumnwallsonthephysicalandchemicalaspectsofchemicalreactorperformancefromtheengineeringapplicationpointofviewwiththeaimofforminganadequateconceptforguidingthedesignofmultiphasefluidizedbedchemicalreactors.

简介：Interleukin-18(IL-18)wasdiscoveredasaninterferon-γ-inducingfactorandhadacriticalroleininflammatoryandimmuneresponse.Itstimulatesnaturalkiller(NK)andTcellsandenhancesTh1immuneresponse.Theseactivatedimmunecellseliminatecancercellsandvirus-infectedcellseffectively.However,IL-18hasalsobeenfoundtopromotetumorprogression.HigherexpressionorsecretionlevelofIL-18isdetectedinvariouscancercellsincomparisonwithnormalcontrol,andIL-18isabletoinduceangiogenesis,migration/metastasis,proliferationandimmuneescape.ThesedualeffectsandthemechanismofIL-18needtobeinvestigatedfurtherasitrelatestocancer.

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简介：AbstractPancreatic ductal adenocarcinoma is the main cause of cancer-related mortality, with a lack of effective treatments and overall survival rates far lower than other solid cancers. This clinical challenge is related to late diagnosis as well as primary or acquired resistance to therapy-induced apoptosis. Targeting nonapoptotic cell death pathways may provide alternative therapeutic strategies to overcome drug resistance. In particular, recent studies have suggested that ferroptosis, a type of iron-dependent nonapoptotic cell death, is a promising target for pancreatic ductal adenocarcinoma. Ferroptosis can be triggered by inhibiting or activating the redox or iron metabolism-related pathways, mediated by extrinsic/membrane transports (e.g., solute carrier family 7 member 11) or intrinsic/enzymes (e.g., glutathione peroxidase 4). Although the exact effector molecule remains obscure, reactive oxygen species-induced lipid peroxidation and subsequent plasma membrane damage appears to play a central role in mediating ferroptotic death. While treatment-induced ferroptosis is beneficial to suppress tumor growth, inflammation-related immunosuppression caused by ferroptotic damage may promote the occurrence of pancreatic ductal adenocarcinoma. In this review, we outline the latest knowledge about the regulation and function of ferroptosis in pancreatic tumorigenesis and therapy.

简介：上期我们报导过“技嘉公司采用i915P芯片组的GA-81915P-SLI主板也能实现SLO暨双显卡协同工作”的新闻，现在技嘉正式公布了让Intel915P实现多重GPU协同工作的技术名称为81915PDualGraphicsCore，支持NVIDIAGeForce6600GT与6800GT显卡，采用该技术的主板配备两组PCI-Ex16插槽，实际工作模式为一组x16加一组x4。目前尚不清楚是否有别家主板厂商也会在i915P芯片组产品上加入该技术或类似功能。

简介：逛逛电子市场就会发现：目前8x的DVD—Dual价格已普遍降至千元以下，甚至会比DVD—R／RW或者DVD+R／RW机种还要便宜。降价之快之猛，让人在欣喜之余又多少有些担心……。

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