简介：

简介：客观：复制错误(RER)与colorectal癌(CRC)的开始和开发有关。调查RER+和RER的不同生物行为？CRC。方法：染色PCR单个的海滨符合构造多型性(PCR-SSCP)和使中毒的polyacrylamide胶化电气泳动方法的银被用来在染色体2上在4loci检测microsatellite不稳定性(MSI)，5，17在60colorectal癌(CRC)和他们的配对的正常组织的嵌入石蜡的标本。如果，RER+被获得2或更多的loci作为获得额外的乐队表现了。结果：结果证明RER+在19/60CRC，7个案例在之中有家庭历史被发现。根据阿姆斯特丹的标准，4作为世袭nonpolyposiscolorectal癌症(HNPCC)被诊断，并且哪个3个案例是RER+。在HNPCC(75%)的比率RER+在分散的CRC(28.5%)之中比那显著地高。大多数RER+CRC有糟糕区分的腺癌的特征(P<0.01)，包含冒号的右边的趋势(P<0.05)，有家庭历史的一个更高的比例(P<0.05)，Ducke的A和B阶段(P<0.05)。结论：结果显示RER+是在CRC的一个相对普通的分子的事件。在RER+和RER之间有不同clinico病理学的特征和行为吗？CPC。

简介：ＡＣＡＳＥＲＥＰＯＲＴＯＦＰＲＩＭＡＲＹＳＱＵＡＭＯＵＳＣＡＲＣＩＮＯＭＡＯＦＴＨＥＥＮＤＯＭＥＴＲＩＵＭＨｅＷｅｎｃｕｉ何文翠；ＷｕＪｉｎｇ吴静；ＣｈａｎｇＪｉｅ唱捷；（ＴｈｅＳｅｃｏｎｄＡｆｆｉｌｉａｔｅｄＨｏｓｐｉｔａｌ，Ｘｉ’ａｎＭｅｄｉｃａ...

简介：ＭＲＩＦＥＡＴＵＲＥＳＡＮＤＲＥＳＥＣＴＡＢＩＬＩＴＹＰＲＥＤＩＴＩＯＮＯＦＥＳＯＰＨＡＧＥＡＬＣＡＲＣＩＮＯＭＡＫｏｎｇＸｉａｎｇｑｕａｎ孔祥泉Ｌｕｏｈａｎｃｈａｏ罗汉超ＰｅｎｇＺｈｅｎｊｕｎ彭振军ＬｉｕＤｉｎｇｘｉ刘定西ＤｅｐａｒｔｍｅｎｔｏｆＲ...

简介：客观：学习在胸方法的ductalcarcinomainsitu的作为一个预示的因素的组织学的分级的意义：根据凡·奈鈥檚分类，胸的ductalcarcinomainsitu(DCIS)的32个盒子被划分成三个组。结果：低等级(很好区分的、低等级DCIS)12个病人(37.5%)；中间的等级，9个病人(28.1%)；高等级(糟糕区分的DCIS)11个病人(34.4%)。在高等级DCIS之中，histologic子类型是粉刺(9个病人)，micropapillary(1个病人)和固体(1个病人)。在高等级DCIS的积极表示ofc-erbB-2，p53和MIB-1在中间、低的等级DCIS比那高。高等级和低等级DCIS之间的差别是重要的(P<0.05)。表示嗯在高等级，DCIS在中间、低的等级DCIS是比那低的。结论：胸ductalcarcinomainsitu的组织学的分级可以是一个好预示的因素。

简介：FromJune,1986toJune1989,24casesofhilarbileductcarcinomawereexploredintheSurgicalDepartmentofGeneralHospitalofPLA,16/24caseswereresected,aresectabilityrateof66%.Theincreaseofresectabilityratewasduetoearlierrecognitionofthisconditionandtheextensionofsurgery,includingmajorresectionofliveraswellasradicaldissectionofthehepato-duodenalligamentandrepairativeoperationsonthebloodvessels.Amongthese16cases,majorhepaticresectionwasperformedin10cases,inwhich,3casesofresectionsofthemiddlelobeoftheliverweredoneinsteadofrightorextendedrightlobectomy.Nooperativemortalityinthe30days’postoperativeperiod,butthepostoperativemorbidityratewasstillhighandmostofthecomplicationswererelatedtobiliaryleakageandinfection.Threepatientsdiedinthefollowupperiodat6,14and15monthsrespectively.Allofthemdiedfrombiliaryinfection.Theremaining13patientswerestillalive,thelongestbein

简介：ＴＨＥＳＴＵＤＹＯＦＥＳＴＲＯＧＥＮＡＮＤＰＲＯＧＥＳＴＥＲＯＮＥＲＥＣＥＰＴＯＲＩＮＮＡＳＯＰＨＡＲＹＮＧＥＡＬＣＡＲＣＩＮＯＭＡＺｈｅｎｇＴｉａｎｒｏｎｇ郑天荣；ＬｉＪｉａｎｃｈｅｎｇ李建成；ＬｉｕＸｉｕｙｉｎｇ刘秀英；（Ｄｅｐａｒｔｍｅｎｔｏｆ...

简介：WithDNA-mRNAhybridizationinsitutechnique,theexpressionoffiveoncogenes,c-N-ras,c-Ki-ras.c-Ha-ras,c-mycandc-fos,wasobservedintwocasesofhumanhepatocellularcarcinoma.Theexpressionofc-N-ras&c-foswasgreatlyenhancedintumortissuesofthetwocases,andabout25%-50%ofthetumorcellsshowedpositiveexpression.Theotherthreeoncogenesnamelyc-Ki-ras,c-Ha-ras&c-myc,werenotdetectedinthesetwocarcinomasorinthenon-cancerouslivertissuesadjacenttothecarcinomas.Itissurmisedthatc-N-rasandc-fosmayplaycoordinativeroleinmaintainingthemalignantphenotypeofhumanprimaryhepatocellularcarcinoma.

简介：ＡＤＥＮＯＳＱＵＡＭＯＵＳＣＡＲＣＩＮＯＭＡＯＦＴＨＥＮＡＳＯＰＨＡＲＹＮＸＣＯＮＴＡＩＮＩＮＧＥＢＶＩＲＵＳ，ＡＰＲＯＰＯＳＯＦＡＣＡＳＥＺｈａｎｇＦｅｎｇ张锋；ＺｈａｎｇＣｈａｎｇｑｉｎｇ张昌卿；ＺｈａｎｇＪｉｎｘｉａ张锦霞；ＺｏｎｇＹｏｎｇｓｈ...

简介：ＤＩＥＬＥＣＴＲＩＣＰＲＯＰＥＲＴＩＥＳＯＦＨＵＭＡＮＢＲＥＡＳＴＣＡＲＣＩＮＯＭＡＡＮＤＳＵＲＲＯＵＮＤＩＮＧＴＩＳＳＵＥＳＤＩＥＬＥＣＴＲＩＣＰＲＯＰＥＲＴＩＥＳＯＦＨＵＭＡＮＢＲＥＡＳＴＣＡＲＣＩＮＯＭＡＡＮＤＳＵＲＲＯＵＮＤＩＮＧＴＩＳＳＵＥ...

简介：ＡＣＬＩＮＩＣＡＬＲＥＰＯＲＴＯＦＲＥＦＲＡＣＴＯＴＹＣＡＲＣＩＮＯＭＡＯＦＯＶＡＲＹＡＮＤＦＡＬＬＯＰＩＡＮＴＵＢＥＴＲＥＡＴＥＤＷＩＴＨＴＡＸＯＬＣａｉＳｈｕｍｏ蔡树模；ＴａｎｇＪｉｅ汤洁；ＦａｎＪｉａｎｘｕａｎ范建玄；ＷｅｎｇＺｈｏｎｇｙｉｎｇ...

简介：客观：在人的hepatocellular癌(HCC)在HLA医生表示上调查干扰素(IFN)的管理效果。方法：房间衬里的在4种HCC的HLA医生的表示，HHCC，SMMC-7721，BEL-7402，HCC-9204和一个正常的肝房间衬里QZG在被IFN-或IFN-的不同剂量刺激前后与immunohistochemicalABC和ELISA方法被检测。结果：仅仅SMMC-7721房间的小部分表示了另外的房间线的HLA医生，和所有是在有IFN-或IFN-的刺激前否定的HLA医生。HLA医生表示在刺激以后5根房间线在所有被提高，并且它与IFN的剂量被相关。QZG房间不比HCC房间明显。IFN-的效果比IFN-的更明显。结论：IFN能在HCC房间提高HLA医生表示。

简介：

简介：SupraglotticlaryngectomywasfirstreportedbyAlousein1974andacceptedgradually.{’lAtventricularlevelincludingventricleband,vestibule,aryepiglotticfold,epiglottis,preepiglotticspaceandhyoidboneexcisionwascompleted.Itwasalsocalledhorizontalsupra-hemilaryng...

简介：Objective:Tostudytheexpressionofvascularendothelialgrowthfactor(VEGF)andmicrovesseldensity(MVD)inesophagealsquamouscellcarcinoma(ESCC)andclarifytheassociationofVEGFexpressionwiththeangiogenesisandprognosticvalueofthisdisease.Methods:Eighty-twocaseswithprimaryESCCtreatedwithradicaloperationinDepartmentofSurgeryfromJan1981throughMay1994wereenrolled.VEGFexpressionandMVDvaluewereexaminedbyimmunohistochemicalstaining,thestreptavidin-biotinperoxidasecomplexmethod(SPmethod),usinganti-VEGFpolyclonalantibodyandanti-Factor-VIIIantibody,respectively.WealsoanalyzedtherelationshipbetweenVEGFexpressionandMVDvalueandpostoperativesurvivalrateofpatients.Results:Ofthe82cases,63.4%casesshowedpositiveforVEGFintumorcellsandthemedianofMVDintumorwas37(9-150)·mm-2.TherewasaclosecorrelationbetweenMVDandVEGF(P=0.001).The5-yearsurvivalrateofpatientswithlowandhighMVDwas34.1%and12.2%,respectively.The5-yearsurvivalratewas46.7%inpatientswithVEGF-negativetumorand11.5%inpatientswithVEGF-positivetumor.Thesedifferenceswerestatisticallysignificant(P=0.017andP<0.001,respectively).Conclusion:InESCC,angiogenesisismediatedmainlybyVEGFandVEGFmaybeassociatedwithtumorprogressionandincreasedmalignancyviaangiogenesis.

简介：摘要：在中介或先进的胰腺的头癌上改进辩解的效果。方法：手术与intermediated或先进的胰腺的头癌在26个病人被动。在癌上与一根电子横梁与intraoperative放射疗法相结合的Cholecystojejunostomy或choledochojejunostomy从1996年5月被执行到1998年5月。同时，多功能的可植入的药交货系统的导管为手术后的灌注化疗经由胃与十二指肠的动脉被插入。结果：327月后续调查建议肿瘤在治疗的功课以后在不同的度缩小了。所有病人疼痛被减轻。6月、12月、24月的幸存率是100%，93.9%和20%分别地。5个死了的病人的平均幸存时间是17.8个月。结论：这操作是很完成与中介或先进的胰腺的头癌延长病人的生活。

简介：ＴＨＥＤＩＡＧＮＯＳＩＳＡＮＤＴＲＥＡＴＭＥＮＴＦＯＲＲＥＣＵＲＲＥＮＴＤＹＳＰＨＡＧＩＡＯＦＥＳＯＰＨＡＧＥＡＬＣＡＲＣＩＮＯＭＡＡＦＴＥＲＲＡＤＩＣＡＬＲＡＤＩＯＴＨＥＲＡＰＹＣｈｅｎＫｅｎｅｎｇ陈克能ＣｈｅｎｇＢａｎｇｃｈａｎｇ程邦昌Ｄｅｐａ...

简介：瞄准：在食道的有鳞的房间癌(ESCC)调查midkine的表示并且与clinicopathological特征分析它的关系。方法：RT-PCR和免疫细胞化学的染色被用来分别地在EC109房间检测midkinemRNA和蛋白质的表示。然后，在ESCC样品的66种情况中的midkine的表示被免疫组织化学对人的midkine用单音的同种细胞的抗体检测。结果：Midkine被RT-PCR和免疫细胞化学在EC109房间表示。免疫反应在56.1%被检测(37/66)ESCC样品。midkine的表示在肿瘤房间的细胞质被发现。尤其是，midkine的紧张在充满容器和肿瘤的入侵的边阶的区域是更强壮的。Midkine更强烈地比在中等并且糟糕区分的肿瘤在很好区分的肿瘤(76.9%)被表示(43.1%和41.2%，分别地)(P<0.05)。在midkine之间没有统计上重要的关联在ESCC的表示和性，年龄，临床的阶段，淋巴节点转移或幸存。结论：Midkine完了在ESCC表示了。它可以在肿瘤血管生成和侵略起一个作用。midkine的表示在ESCC与肿瘤细胞分化被相关。肿瘤房间区分越多糟糕，midkine表示越多weaker。

简介：Objective:Tostudytheexpressionofdendriticcellsinhumanrenalcellcarcinomaandexplorethecause,sotorevealthemechanismofescapingimmunesurveillanceinRCC.Methods:TheexpressionsofCD83+DCS,CD1a+DCS,VEGFandTGF-β1intumoral,peritumoralandnormalkidneytissuesofRCCin30casesweredetectedbyimmunohistochemistryusingstreptavidin/peroxidese(SP)Results:CD83+DCSweremainlylocatedintheperitumoralareas;whereasCD1a+DCS、weremainlyretainedwithinthecancernests.ThenumberofCD83+DCSwasinverselycorrelatedwiththeclinicalstage(P<0.05);buttherewerenosignificantcorrelationsbetweenthenumberofCD1a+DCS、andtheclinicalstage(P>0.05).TheexpressionsofCD83+DCSandCD1a+DCShavesignificantdifferencebetweenthetumoral,peritumoralandnormalkidneytissues(P<0.001).TheexpressionofVEGFandTGF-β1weresignificantlylowerinsampleswithhighlyinfiltratingCD83+DCS(P<0.05);WhereasCD1a+DCSwerenot(P>0.05).Conclusion:DChasthetendencytogatheringintumor,butbecauseoftheimmunosuppressivecytokins,forexampleVEGFandTGF-β1,inhibitsthematurationofDC,therearelessmatureTIDCS(CD83+TIDCS)inthetumoraltissues,theyaremainlylocatedintheperitumoralareas.ThismaycontributetothemechanismofescapingimmunesurveillanceinRCC.

简介：Objective:ToexploretherelationshipbetweenSTK15geneabnormalexpressionandlaryngealcarcinoma.Methods:Tumortissuesandmatchednormaltissuesweretakenfrom55LSCCpatients.Semi-quantitativereversetranscription-polymerasechainreaction(RT-PCR)wasusedtodetectSTK15expressionin110specimens.Results:In38ofthe55cases(69.1%),theSTK15expressionatthemRNAlevelswashigherthanthatofthepairednormaltissue.TheratioofADV(averagedensityvalue)ofSTK15genetoADVofβ-actingenewas1.22±0.49inthecancertissue,and0.99±0.54inthepairednormaltissuewithasignificantdifference(t=4.539,P<0.01).Conclusion:TherewasobviousassociationbetweentheSTK15overexpressionandlaryngealcarcinoma.Itmayserveasanalternativemechanismofactivatingthepathogenesisofhumanlaryngealsquamouscellcarcinoma.