简介:岛津公司最新研发的数字化移动式X线摄影系统——MobileDaRt系统,是岛津X线的生产经验与数字化技术的完美结晶,填补了放射科的最后一个平板“死角”,使数字化网络医院日趋完善。系统采用14*17时大尺寸平板探测器,在曝光后3秒钟就可以显示图像,主机可以储存2000幅图像,同时X线系统的新型触摸屏易于操作,而且用户界面直观。X线系统采用60kHz的高频发生器,可以产生稳定、优质的X线输出,提高图像质量的同时,大幅降低了辐射剂量。MobileDaRt主机采用电动驱动方式,移动灵活轻便,独特的旋转伸缩式球管臂结构,使在狭小的病房内的定位操作非常方便。为手术中、重症患者、骨科患者以及传染病人在隔离区内摄影后的即时诊断、远程会诊提供最佳解决方案。
简介:ToinvestigatetheimbalancestateofhelperTlymphocytes(Th)andcytotoxicTlympho-cytes(Tc)andtherolesofTh1/Th2/Th3andTc1/Tc2cellsinrenaltransplantationrejection,theper-centagesofthesecellsinperipheralbloodof24casesofrenaltransplantationrecipientswithacutere-jectionandthedynamicchangesoftheCD4/CD8ratioweredeterminedbyflowcytometryanalysis,while30casesofhealthyindividualsweresetupascontrols.Inthesehealthycontrols,thepercentagesoftheTh1,Th2andTh3cellswere(10.45±8.15)%,(5.05±4.15)%and(3.90±3.21)%,andthoseofTc1andTc2cellswere(9.83±7.03)%and(4.51±2.17)%,respectively.However,thepercentagesofTh1andTclcellsinperipheralbloodofthestablerecipientsaftertransplantationwere(7.29±5.62)%and(7.04±5.15)%,showingdefinitereduction,whilethoseofTh2,Th3andTc2cellsshowedsignificantincrease,(6.34±5.67)%,(4.94±4.14)%and(6.86±4.42)%,respectively.Incaseofrecipientswithacuterejection,thepercentagesofTh1andTc1cellsappearedtobe(18.55±13.21)%and(15.84±11.72)%,alsoshowingsignificantincrease,butthoseofTh2,Th3andTc2cellsappearedtobereduced,(4.19±3.62)%,(3.02±2.83)%and(3.88±1.63)%,respectively.Significantdifferencescouldbedetectedamongthesethreegroups(P<0.05).TheCD4/CD8ratioincaseswithacuterejectionwashigherthanthoseofstablerecipients(2.24±0.59vs1.95±0.45),butthatofthestablerecipientsandhealthycontrols(1.98±0.31)showednoanysignificantdifference.Fromtheaboveobservation,itisevidentthatimbalancebetweenTh1,Th2andTh3withTc1andTc2cellsmayexistafterrenaltransplantationandprobably,theim-muneimbalancemaybeinducedthroughthesecretionofcytokinesINF-γbyTh1orTc1cells,Ⅱ-4byTh2andTc2cellsandTGF-βbyTh3.
简介:Prematureventricularcontraction(PVC)isthemostfrequentarrhythmiaencounteredinclinicalpractice.PVCmayoccurinhealthsubjects,whichisnotimminentlylife-threateningbutmayrequiretherapiestopreventfurtherproblems.So,thetimelyPVCrecognitionbecomesveryimportantfortheanalysisofelectrocardiogram(ECG),especiallyfortheremoteECGmonitoringusingmobilephones.Inthispaper,aconstructionmethodofpersonalizedECGtemplateandaPVCrecognitionmethodbasedontemplatematchingwerestudied.Firstly,weselected43ECGrecordingsfromtheMIT-BIHarrhythmiadatabase.Allrecordingsweredividedintotwodatasets(DS1fortrainingandDS2fortesting)andeachdatasetapproximatelycontainedthesameproportionofPVCbeats.Subsequently,foreachrecording(30min)inDS1,thefirst5minrecordingswereusedtoconstructthepersonalizedECGtemplateandthelast25minrecordingswereusedfortheR-wavepeaksdetectionandPVCrecognition,wherethetemplatematchingmethodwereused.ThevalidityoftheproposedmethodswastestedusingDS2.Theresultsshowedthat:1)highbeatdetectionaccuracywasachievedforbothPVCbeatsandnon-PVCbeats;2)thesensitivityandspecificityofPVCrecognitionwere99.11%and99.96%forthefirst5minrecordingsrespectively,99.17%and99.43%forthelast25minrecordingsrespectively.Alltheproposedmethodscanbereal-timeperformed,whichshowapromisingprospectfortheapplicationofECGmobilephones.
简介:目的将在18-24年在大学生开车调查手机和安全带使用的流行。学习由二个阶段组成了的方法。在第一个阶段,一张问询表被给265个大学生。样品包含了188男性和77女性。在第二个阶段,从2007年3月20日与道路事故损害相关到2008年3月20日的数据在苏格兰教会会员从Bahonar中央医院被收集,伊朗,并且分析。在那里的结果是14.0%男性和19.0%女参加者旅行当在城市的道路上开车时,系上带子。它显示参加者解开了或用手机,更多涉及事故在持续三年。这研究也揭示了19.0%男性和司机们认为在开车使用手机不危险的4.2%女性。最高的损害和性质损坏碰撞率每100000个居民是87和137,它1824年发生在男组。并且30%所有死亡是1924岁。超过50%大学生旅行了的结论解开了。女性少些涉及道路事故损害。18-24年的大学生有损伤和头损害的最高的百分比。
简介:TcellhomeostasiscommonlyreferstothemaintenanceofrelativelystableTcellnumbersintheperipherallymphoidorgans.AmongthelargenumbersofTcellsintheperiphery,Tcellsexhibitstructuraldiversity,I.e.,theexpressionofadiverserepertoireofTcellreceptors(TCRs),andfunctionaldiversity,I.e.,thepresenceofTcellsatna(I)ve,effector,andmemorydevelopmentalstages.AlthoughthehomeostasisofTcellnumbershasbeenextensivelystudied,investigationofthemechanismsunderlyingthemaintenanceofstructuralandfunctionaldiversityofTcellsisstillatanearlystage.ThefundamentalfeaturethroughoutTcelldevelopmentistheinteractionbetweentheTCRandeitherselforforeignpeptidesinassociationwithMHCmolecules.Inthisreview,wepresentevidenceshowingthathomeostasisofTcellnumberanddiversityismediatedthroughcompetitionforlimitingresources.ThenumberofTcellsismaintainedthroughcompetitionforlimitingcytokines,whereasthediversityofTcellsismaintainedbycompetitionforself-peptide-MHCcomplexes.Inotherwords,diversityoftheself-peptiderepertoirelimitsthestructural(TCR)diversityofaTcellpopulation.Wespeculatethatcognatelowaffinityself-peptides,actingasweakagonistsandantagonists,regulatethehomeostasisofTcelldiversitywhereasnon-cognateornullpeptideswhichareextremelyabundantforanygivenTCR,maycontributetothehomeostasisofTcellnumberbyprovidingsurvivalsignals.Moreover,self-peptidesandcytokinesmayformspecializednichesfortheregulationofTcellhomeostasis.
简介:Objective:Toinvestigatetheeffectofbreast-conservationtherapyinearlystagebreastcancer.Methods:Atotalof234earlystagebreastcarcinomapatientsreceivedbreastconservingtreatmentinourhospital.Aftertheoperation,theyunderwentadjuvantchemotherapyandradiotherapy.Allofthesepatientsdesiredtopreservetheirbreasts.Results:Aftermedianfollow-upof29.46months(rangefrom3to100months),3caseshadlocalrelapseand8caseshaddistantmetastasis.Theoverallsurvivalrateof5yearwas96.7%,andthediseasefreesurvivalrateof5yearwas87.85%.Conclusion:Forearlystagebreastcarcinomapatients,classicquadrantectomy,axillarydissectionandpost-operativeadjuvantchemotherapyandradiotherapyleadtoexcellentlocalcontrolandgoodsurvival.
简介:T房间受体(TCR)的结扎独自是不够的导致T淋巴细胞的完整的激活。介绍房间(APC)和T房间的抗原上的另外的ligand受体相互作用(costimulation)被要求。T房间costimulation被显示了为得到有效T房间回答必要,包含在T房间开发期间的所有阶段。然而,costimulation由影响T房间的功能的机制仍然需要被阐明。在最近的年里,在癌症,传染疾病以及自体免疫的疾病作为潜在的治疗在costimulation的研究被献殷勤。在这评论,我们讨论了调整T房间增长,房间周期前进,cytokine生产,幸存,和存储器开发的细胞内部的costimulation信号。一般来说,phosphoinositide-3kinase(PI3K)的小径/proteinkinaseB(PKB,也作为Akt知道)/nuclear因素B(NF-B)可能对许多costimulatory效果中央。通过这些小径,costimulation由survivin和曙光B表示的维护控制T房间扩大和增长,并且由调整bcl-2家庭成员的表达式支撑长期的T房间幸存和存储器开发。
简介:MicroRNAs(miRNAs)aresmall,non-codingsingle-strandedRNAsthatcanmodulatetargetgeneexpressionatposttranscriptionallevelandparticipateincellproliferation,differentiation,andapoptosis.Tcellshaveimportantfunctionsinacquiredimmuneresponse;miRNAsregulatethisimmuneresponsebytargetingthemRNAsofgenesinvolvedinTcelldevelopment,proliferation,differentiation,andfunction.Forinstance,miR-181familymembersfunctioninprogressionbytargetingBcl2andCD69,amongothers.MiR-17tomiR-92clustersfunctionbybindingtoCREB1,PTEN,andBim.ConsideringthatthesuppressionofTcell-mediatedimmuneresponsesagainsttumorcellsisinvolvedincancerprogression,weshouldinvestigatethemechanismbywhichmiRNAregulatesTcellstodevelopnewapproachesforcancertreatment.
简介:【摘要】T细胞治疗成为癌症的重要疗法之一,过继T细胞转移治疗、嵌合抗原受体T细胞(CART)和T细胞受体嵌合型T细胞(TCRT)取得了一定的效果。过继T细胞转移治疗的适应症较广,有效率偏低,CART中效果较好的是CART-CD19,主要应用于B细胞白血病和淋巴瘤的治疗,TCRT可应用于实体瘤治疗,但一旦肿瘤抗原突变就会造成“脱靶”。本文概括了CART和TCRT的原理和作用特点,并对它们存在的不足之处进行了分析。