简介:Theeffectandmechanismofcarmustine(BCNU)combinedwithall-transretinoicacid(ATRA)ontheapoptosisofhumanglioblastomaU251cellswereinvestigatedbymeansof3-(4,5-dimethylthiazol-2-yl)-2,5-diphe-nyltetrazoliumbromide(MTT)assay,flowcytometry,reversetranscription-polymerasechainreaction(RT-PCR)andWesternblotanalysis.TheresultsshowthatBCNUorATRAshowstime-anddose-dependentinhibitioneffectsonhumanglioblastomaU251cellsandthecombinationofBCNUwithATRAshowsansynergisticinhibitioneffectonhumanglioblastomaU251cells,andthecombinedBCNUandATRAcansignificantlyinhibittheproliferationofhumanglioblastomaU251cells,andinducetheapoptosisofthem,makingthecellsarrestinthestageofG1phase,thestageofSandG2phasesdecline,therateoftheapoptosisofhumanglioblastomaU251cellsincrease,thecorrespondingmRNAexpressionofcyclinEandcyclin-dependentkinase2(CDK2)downregulatedandthecorrespon-dingmRNAexpressionofp27kip1unregulated.Inaddition,thecombinedBCNUandATRAreducedtheproteinexpressionofnuclearfactorkappaB(NF-κB).Takentogether,theseresultssuggestthatthetreatmentofhumanglioblastomaU251cellswithacombinationapplicationofATRAandBCNUcanexertsynergisticeffect,thecourseofthiskindofcombinationchemotherapymaylikelybeassociatedwithmultiplemolecularmechanismsforapoptosis,furthermore,thecyclinEandp27kip1shouldbeconsideredasnoveltargetsforcontrollingthegrowthofglioblastomacells.
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简介:引进分次Armendariz环的概念,讨论了分次环R=n∈ZRn及由它导出的非分次环R,R0,及R[x]之间关于Armendariz环性质的关系,并推广了[8]的结论,得到在R=n∈ZRn是Z-型正分次环的前提下,若R是分次Armendariz,分次正规环,则R是P.P.环(Baer环)当且仅当R是分次P.P.环(分次Baer环).
简介:Multimediastreamingservedthroughpeer-to-peer(P2P)networksisboomingnowadays.However,theend-to-endstreamingqualityisgenerallyunstableduetothevariabilityofthestateofserve-peers.Ontheotherhand,proxycachingisabandwidth-efficientschemeforstreamingovertheInternet,whereasitisasubstantiallyexpensivemethodneedingdedicatedpowerfulproxyservers.Inthispaper,wepresentaP2PcooperativestreamingarchitecturecombinedwiththeadvantagesofbothP2Pnetworksandmultimediaproxycachingtechniquestoimprovethestreamingqualityofparticipatingclients.Inthisframe-work,aclientwillsimultaneouslyretrievecontentsfromtheserverandotherpeersthathaveviewedandcachedthesametitlebefore.Inthemeantime,theclientwillalsoselectivelycachetheaggregatedvideocontentsoastoservestillfutureclients.Theassociateprotocoltofacilitatethemulti-pathstreamingandadistributedutility-basedpartialcachingschemearedetailedlydis-cussed.Wedemonstratetheeffectivenessofthisproposedarchitecturethroughextensivesimulationexperimentsonlarge,Inter-net-liketopologies.
简介:SomecharacterizationsoftheconditionalexpectationoperatorsonLebesgue-BochnerspacesL_p(μ,X)aregiven,where1≤p<∞,p≠2.AlsoanexampleisgiventoshowthatthecharacterizationsoftheconditionalexpectationoperatorsonL_p(μ,X)aredifferentfromthatonL_p(μ)_zFinally,arepresentationoftheconstant-preservingcontractiveprojectiononspacesL_p(μ,X)isgotwhen0<p<1.
简介:运用转移矩阵的技巧,本文给出了戴帽B27N27硼-氮zlgzag纳米管的克库勒结构数的计算公式.在实际计算中,根据管的对称性,转移矩阵的阶得到了显著地降低.
简介:<正>LetD={z∈:|z|<1}andφbeanormalfunctionon[0,1).Forp∈(0,1)suchafunctionφisusedtodefineaBergmanspaceA~p(φ)onDwithweightφ~p(|·|)/(1-|·|~2).Inthispaper,thedualspaceofA~p(φ)isgiven,fourcharacteristicsofCarlesonmeasureonA~p(φ)areobtained.Moreover,asanapplication,threesequenceinterpolationtheoremsinA~p(φ)arederived.
简介:Letp(z)=beapolynomialdegreenandletThenaccord-ingtoBernstein’sinequality||p’||
简介:Thepurposeofthepresentpaperistoevaluatetheerroroftheapproximationofthefunc-tionfL1[0,1]byKantorovich-BernsteinpolynomialsinLp-metric(0<p<1).
简介:InthispaperwestudytheconvergencenfaclassofmeansonHp(G)(0<p<1),themeanstaketheBochner-Rieszmeansin[1],thegeneralizedBochner-Rieszmeansin[2],andtheoperatorsTΦrin[3]asspecialcases.Weobtainweak-typeestimatesfortheassociatedmaximaloperatorsandthemaximalmeanboundednessforthemeans.
简介:P2Psystemsarecategorizedintotree-basedandmesh-basedsystemsaccordingtotheirtopologies.Mesh-basedsystemsareconsideredmoresuitableforlarge-scaleInternetapplications,butrequireoptimizationonlatencyissue.Thispaperproposesacontentsubscribingmechanism(CSM)toeliminateunnecessarytimedelaysduringdatarelaying.Anodecansendcontentdatatoitsneighborsassoonasitreceivesthedatasegment.Noadditionaltimeistakenduringtheinteractivestagespriortodatasegmenttransmissionofstreamingcontent.CSMconsistsofthreesteps.First,everynoderecordsitshistoricalsegmentslatency,andadoptsgammadistribution,whichpossessespowerfulexpressionability,toexpresslatencystatistics.Second,anodepredictssubscribingsuccessratioofeveryneighborbycomparingthegammadistributionparametersofthenodeanditsneighborsbeforeselectinganeighbornodetosubscribeadatasegment.Theabovestepswouldnotincreaselatencyastheyareexecutedbeforethedatasegmentsarereadyattheneighbornodes.Finally,thenode,whichwassubscribedto,sendsthesubscribeddatasegmenttothesubscriberimmediatelywhenithasthedatasegment.ExperimentsshowthatCSMsignificantlyreducesthecontentdatatransmissionlatency.
简介:ThespectrumoftheΣ(1193)excitedstates,Σ,withisospinI=1andstrangenessS=??1isoneofthemostimportantissuesinhadronicphysics.TheΣresonancesaremostlyproducedandstudiedinK-inducedreactions.ManyΣresonancesarenowcatalogedbytheParticleDataGroup[1].However,ourknowledgeoftheseresonancesisstillverypoor.Intheenergyregionbelow2GeV,onlyafewofthemarewellestablished,suchastheΣ(1385)ofspin-parityJP=3=2+,Σ(1670)ofJp=3=2??andΣ(1775)ofJp=5=2??.Theothersarenotwellestablishedandsomeofthemareevenoflargeuncertaintiesontheirexistence.Thus,thestudyoftheΣresonancewiththeavailableexperimentaldataisnecessary.