简介：从血盆草的水提取物的正丁醇部分分离得到两个微量酚甙，根据理化常数及波谱分析鉴定为异槲皮甙和紫云英甙。这两个化合物均为首次从该植物中分得。

简介：AIMEndothelin1(ET-1),apotentvasoconstrictorpeptide,isalsoregardedasanimportantetiologicalfactorinvolvedinmanycardiacdiseaseslikeheartfailureandcardiachypertrophy.Itmediatespathologicchangesbyformingan""""ETaxis""""attheupstreamtoionchannels,suchasstimulatingoxidantstress,elicitingcardiacremodelingbyproliferationofcardiomyocytes,inducingapoptosis,affectingsignaltransductionpathway,andmodulatingintranucleargenetranscription.ThepurposeofthisstudywastoinvestigatethepivotalrolebyETaxisinworseningarrhythmiasandcardiacfunctioninexperimentalhypertrophiccardiomyopathy(HCM)andheartfailure(HF)models.METHODSTheratHCMmodelwasinducedbys.cL-thyroxin(L-thy,0.2mg/Kg/d)for10d,