简介：AIMEndothelin1(ET-1),apotentvasoconstrictorpeptide,isalsoregardedasanimportantetiologicalfactorinvolvedinmanycardiacdiseaseslikeheartfailureandcardiachypertrophy.Itmediatespathologicchangesbyformingan""""ETaxis""""attheupstreamtoionchannels,suchasstimulatingoxidantstress,elicitingcardiacremodelingbyproliferationofcardiomyocytes,inducingapoptosis,affectingsignaltransductionpathway,andmodulatingintranucleargenetranscription.ThepurposeofthisstudywastoinvestigatethepivotalrolebyETaxisinworseningarrhythmiasandcardiacfunctioninexperimentalhypertrophiccardiomyopathy(HCM)andheartfailure(HF)models.METHODSTheratHCMmodelwasinducedbys.cL-thyroxin(L-thy,0.2mg/Kg/d)for10d,
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