简介：AIM:ToperformaMeta-analysistoexplorethecorrelationbetweenmetabolicsyndromeandintraocularpressure(IOP).METHODS:WesearchedPubMedandEmbaseinNovember2017forstudiesdiscussingtherelationshipbetweenmetabolicsyndromecomponentsandIOPinpatients.Pearsoncorrelationcoefficients,oddsratiosandstandardizedbetaswereextractedfrominclusivestudies.Heterogeneityandpublicationbiaswerechecked.RESULTS:Of295articles,10metinclusioncriteriaandprovidedsufficientdataforMeta-analysis.ResultsshowedasignificantpositiverelationbetweenmetabolicsyndromeandIOP(Z=0.47,95%CI:0.15-0.79,P=0.005).Thefivecomponents[waistcircumference,hypertriglyceridemia,highbloodpressure,highfastingglucoseandlowhighdensitylipoprotein(HDL)-cholesterol]ofmetabolicsyndromeallshowedpositivecorrelationwithIOPexceptthelowHDL-cholesterolwhichhadnostatisticalsignificance.ThepooledZwas0.08(95%CI:0.04-0.12),0.16(95%CI:0.11-0.21),0.16(95%CI:0.10-0.22),0.30(95%CI:0.20-0.40)and0.12(95%CI:0.08-0.16),respectively.Begg’stestandEgger’stestshowednoevidenceofsignificantpublicationbiasofthisMeta-analysis.CONCLUSION:OurfindingssuggestthatmetabolicsyndromeanditscomponentsaresignificantlyassociatedwithIOP,besidestheHDL-cholesterol.ThisassociationmaybeusedtocontrolIOPbyinterveningtheoccurrenceofmetabolicsyndrome.

简介：AIM:Toinvestigatewhethertheresponseofacentralhexagonalelementcorrespondingtothemacularareainconventionalmultifocalelectroretinography(mfERG)testswasthesameasthatofexperimentalmfERGusingsinglecentralhexagonalelementstimulation.METHODS:Prospective,observationalstudy.Thirtyhealthysubjectswereincludedinthisstudy.mfERGrecordingswereperformedaccordingtotwoprotocols:stimuluswith37hexagonalelements(protocol1),andstimuluswithasinglecentralelementcreatedbydeactivatingtheother36hexagonalelements(protocol2).Wecompareddifferencesbetweenring1parametersineachprotocol.RESULTS:Inprotocol1,thefirstpositivecomponent(P1)implicittimeandP1amplitudewere37.8±1.8msand6.3±2.7μV.Aftersingleelementstimulation(protocol2),doublepositivewavesappeared.TheimplicittimeandamplitudeofP1were40.7±2.4ms(P<0.001)and9.1±3.3μV(P=0.001),respectively.Theimplicittimeandamplitudeofthesecondpositivecomponent(P2)were68.0±4.5ms(P<0.001,comparedwithP1inprotocol1)and12.3±4.7μV(P<0.001,comparedwithP1inprotocol1),respectively.TheamplitudeofP2inprotocol2wasabouttwotimeshigherthanthatofP1inprotocol1.CONCLUSION:mfERGresponsesofacentralhexagonalelementinasingleelementstimulationprotocolaredifferentfromthoseofmultipleelementstimulation.Thepositivewaveismoreenhancedcomparedtothatoftheconventionalprotocolanditelongatedintotwowavelets.