简介：Otitismediawitheffusionisoneofthemostcommondiseasesinchildren.Itstreatmentremainscontroversial.ClinicalpracticeguidelinesofOMEallowwatchfulwaitingfor3monthsbeforetreatmentifthechildwithOMEisnotatriskforspeech/language/orlearningproblems.Tympanostomytubeinsertionisthepreferredinitialprocedurewhenachildbecomesasurgicalcandidate.ComplementaryoralternativemedicineisnotrecommendedasatreatmentforOME.ThispaperprovidesasystematicreviewofmanagementofOME,whichwehopewillbehelpfulforclinicians.

简介：<正>OtitisMediaisacommondiseaseinthepracticeofotolaryngologyandoneofthefamous"threeinflammationsandonedeafness".Otitismediahasbeenwithhumansfromtheverybeginning.Treatmentforotitismediastartedinthewestin1774andmuchlaterinChina.

简介：ObjectiveTostudytheeffectsofBatroxobinonotitismediawitheffusion(OME),anearlystageofAdhesiveOtitisMedia(AOM),forthepurposeofexpandingourunderstandingoftheroleoffibrinolysisinthepathogenesisofAOM.MethodFortycasesofOME(45ears)wererandomlyselectedtoreceiveintratympanicadministrationofDexamethasoneat5mg/ml(Group1orG1),Batroxobinat1BU/ml(Group2orG2)orBatroxobinat2BU/ml(Group3orG3).Pre-andpost-treatmentchangesinclinicalsymptoms,theAirconductionHearingThreshold(AHT)inpuretoneaudiometryandaverageAHTover0.25to2kHzwerecompared.ResultsDatafrom31cases(33ears)wereavailableforanalysis.AHTsamongthreegroupsweresimilarpriortotreatment(P>0.05).TherateofnormalhearingfollowingtreatmentinG3was70%or7/10,higherthaninG1(41.7%or5/12)andG2(54.5%or6/11)(P<0.05).Therateofimprovementfollowingtreatmentwas81.8%or9/11and80.0%or8/10inG2andG3,respectively,higherthanthatinG1(50.0%or6/12)(P<0.05).ConclusionsTherapeuticeffectsofintratympanicinjectionofBatroxobinonOMEissuperiortotraditionallyusedDexamethasone.Inaddition,higherconcentrationofBatroxobinappearstobesuperiortolowerconcentrations.Thesefindingsconfirmthatfibrinolysisplaysapivotalroleinthepathogenesisofmiddleearadhesionandthatfibrinolyticmedicinecanpreventorreduceadhesiondevelopmentinthemiddleear.

简介：Objective:Todescribeaprotocolforrecordingelectricalpotentialsfromthescalamedia,saccule,andutricleinmice.Method:CBA/Jmicewereusedandpotentialswererecordedwithglasselectrodesinsertedthroughthebasilarmembraneusingapatchclampsystem.Results:Restingpotentialsweresuccessfullyrecordedfromthescalamedia,sacculeandutricleusingdescribedprotocols.Conclusions:Withthemethoddescribed,onecanmeasurerestingpotentialsfromthescalamedia,sacculeandutricle,aswellascochlearmicrophonics(CM)andevenauditorynervecompoundactionpotentials(CAP),inasinglemouse.

简介：BackgroundChronicotitismedia(COM)isasignificantclinicalproblem.UnderstandingthemechanismsofCOMiscriticalforitscontrolandtreatment.However,littleisknownoftheprocessesleadingtoCOMasaresultoflackofanimalmodelsofN-ethyl-N-nitrosourea(ENU)inducedmutationsinotitismediawitheffusion(OME).MethodsOtoscopyandauditorybrainresponse(ABR)evaluationwerecarriedoutundersedationinNmf391nmf/nmfmiceof2,4,6and8monthsofage.Themicewerekilledforstudyofmiddleandinnerearpathology.ResultsTympanicmembranevisualizationandABRthresholdsin1-to8-month-oldNmf391nmf/nmfmiceshowedspontaneousOMEandinnereardiseasesinapproximately100%oftheanimals.ThesignificantelevationofABRthresholdssuggestedasensorineuralcomponentinhearinglossinadditiontotheconductiveloss.Middleandinnerearhistologyshowedvariousdegreesofouterhaircellslossandmiddleearinflammationinallthemice,butnoinflammationcellsintheinnerear.TheABRthresholdat32kHzwassignificantlyelevated.ConclusionsThisstudyshowshistopathologicchangesintheNmf391nmf/nmfmousemodelofCOMwitheffusionthathavenotbeenreportedinhumanCOM.ThisENUinducedmutationmodelofCOMwillbevaluableforthecharacterizationofmiddleearinflammationandinnereardiseaseprocessesthatareinducedbymiddleearinfections.WeproposethatCOMwitheffusioninthisENUinducedmutationmodelisthecauseofthecochleahaircellsdamage.

简介：Objective:Toinvestigatesurgicalindications,operativetechniques,complicationsandauditoryandspeechrehabilitationforcochlearimplant(CI)inchildrenwithotitismediawitheffusion(OME).Materia!andmethods:Thisisaretrospectivereviewofrecordsof24childrenwithbilateralprofoundsensorineuralhearinglossandOMEwhowereimplantedduringJanuary2011toNovember2014intheDepartmentofOtorhinolaryngologyandHeadandNeckSurgeryatthePLAHospital,usingone-stageimplantationviathefacialrecessapproachandroundwindowinsertion.Theincuswasremovedin8casesduringtheimplantationprocedure.Localinfiltrationofdexamethasoneandadrenalineinthemiddleearwasalsoperformed.Postoperativecomplicationswereexamined.PreoperativeandpostoperativequestionnairesincludingCategoriesofAuditoryPerformance(CAP).SpeechIntelligibilityRating(SIR),andtheMeaningfulAuditoryIntegrationScale(MAIS)werecollected.Results:Allelectrodeswereimplantedsuccessfullywithoutanyimmediateordelayedcomplications.Inllammatorychangesofmiddleearmucosawitheffusionwerenotedinallimplantedears.Thescoresofpost-implantCAPandSIRincreasedsignilicantlyinall24cases(t=-25.95and-14.09.respectivelyforCAPandSIR.p<0.05).Conclusions:One-stageCIviathefacialrecessapproachwithroundwindowinsertionissafeandeffectiveincochlearimplantcandidateswithOME,asseeninthe24childreninourstudywhoachievedimprovedauditoryperformanceandspeechintelligibilityafterCI.