简介：Inthisreview,weadvanceanewconceptindevelopingvaccinesand/ordrugstotargetspecificproteinsexpressedduringtheearlystageofBacillusanthracis(anthrax)infectionandaddressexistingchallengestothisconcept.Threeproteins(immuneinhibitorA,GPR-likesporeprotease,andalanineracemase)initiallyidentifiedbyproteomicsinourlaboratorywerefoundtohavedifferentialexpressionsduringanthraxsporegerminationandearlyoutgrowth.Otherstudiesofdifferentbacillusstrainsindicatethatthesethreeproteinsareinvolvedineithergerminationorcytotoxicityofspores,suggestingthattheymayserveaspotentialtargetsforthedesignofanti-anthraxvaccinesanddrugs.
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